(Q28250560)

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Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment

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scholarly article

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Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment (English)

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author name string

Xi-Ping Huang

1

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Vincent Setola

2

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Prem N Yadav

3

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John A Allen

4

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Sarah C Rogan

5

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Bonnie J Hanson

6

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Chetana Revankar

7

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Matt Robers

8

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Chris Doucette

9

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Bryan L Roth

10

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language of work or name

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publication date

October 2009

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Molecular Pharmacology

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76

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4

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710-22

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describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2769050/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

5-hydroxytryptamine (5HT)-induced valvulopathy: compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats

1 reference

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20 March 2017

Possible association between 3,4-methylenedioxymethamphetamine abuse and valvular heart disease

1 reference

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20 March 2017

Valvular heart disease and the use of dopamine agonists for Parkinson's disease

1 reference

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20 March 2017

Dopamine agonists and the risk of cardiac-valve regurgitation

1 reference

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20 March 2017

Drugs and valvular heart disease

1 reference

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20 March 2017

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

1 reference

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20 March 2017

p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling

1 reference

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20 March 2017

Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor

1 reference

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20 March 2017

3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769050

20 March 2017

Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications

1 reference

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20 March 2017

Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769050

20 March 2017

Histologic changes in three explanted native cardiac valves following use of fenfluramines

1 reference

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20 March 2017

Valvular heart disease associated with fenfluramine-phentermine

1 reference

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20 March 2017

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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7 April 2017

The expanded biology of serotonin

1 reference

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29 September 2017

Anatomical profiling of G protein-coupled receptor expression

1 reference

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29 September 2017

Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769050

29 September 2017

N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity

1 reference

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29 September 2017

Lorcaserin (APD356), a selective 5-HT(2C) agonist, reduces body weight in obese men and women

1 reference

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27 November 2018

Quantification of isozyme-specific activation of phospholipase C-beta2 by Rac GTPases and phospholipase C-epsilon by Rho GTPases in an intact cell assay system

1 reference

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27 November 2018

5-Hydroxytryptamine (5HT) receptors in the heart valves of cynomolgus monkeys and Sprague-Dawley rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769050

27 November 2018

Severe multivalvular heart disease: a new complication of the ergot derivative dopamine agonists

1 reference

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27 November 2018

Valvular heart disease in patients taking pergolide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769050

27 November 2018

Identifiers

10.1124/MOL.109.058057

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