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Structural interpretation of pH and salt-dependent processes in proteins with computational methods
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title
Structural interpretation of pH and salt-dependent processes in proteins with computational methods
(English)
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main subject
computational biology
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inferred from title
author name string
Bertrand García-Moreno E
series ordinal
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Carolyn A Fitch
series ordinal
2
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language of work or name
English
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publication date
2004
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published in
Methods in Enzymology
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volume
380
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page(s)
20-51
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cites work
Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Electrostatic contributions to molecular free energies in solution
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extension of the theory of linked functions to incorporate the effects of protein hydration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
pH dependence of stability of staphylococcal nuclease: evidence of substantial electrostatic interactions in the denatured state
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Estimating binding constants for site-specific interactions between monovalent ions and proteins.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Variability in the pKa of histidine side-chains correlates with burial within proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Empirical relationships between protein structure and carboxyl pKa values in proteins.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intrinsic pKas of ionizable residues in proteins: an explicit solvent calculation for lysozyme
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Family of G protein alpha chains: amphipathic analysis and predicted structure of functional domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Calculations of electrostatic interactions in biological systems and in solutions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
What are the dielectric "constants" of proteins and how to validate electrostatic models?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Calculations of enzymatic reactions: calculations of pKa, proton transfer reactions, and general acid catalysis reactions in enzymes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
pKa's of ionizable groups in proteins: atomic detail from a continuum electrostatic model
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Electrostatic calculations of the pKa values of ionizable groups in bacteriorhodopsin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
On the calculation of pKas in proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The determinants of pKas in proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The dielectric constant of a folded protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prediction of pH-dependent properties of proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
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inferred from DOI database lookup
Macroscopic models for studies of electrostatic interactions in proteins: limitations and applicability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modeling of protein conformational fluctuations in pKa predictions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Thermodynamic linkage between the binding of protons and inhibitors to HIV-1 protease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Electrostatic calculations of side-chain pK(a) values in myoglobin and comparison with NMR data for histidines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Electrostatic effects in highly charged proteins: salt sensitivity of pKa values of histidines in staphylococcal nuclease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distance dependence and salt sensitivity of pairwise, coulombic interactions in a protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Improving the accuracy of protein pKa calculations: conformational averaging versus the average structure.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Calculated pH-dependent population and protonation of carbon-monoxy-myoglobin conformers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conformation and hydrogen ion titration of proteins: a continuum electrostatic model with conformational flexibility
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the protein side-chain fluctuations on the strength of pair-wise electrostatic interactions: comparing experimental with computed pK(a)s
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Incorporating protein conformational flexibility into the calculation of pH-dependent protein properties
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Combining conformational flexibility and continuum electrostatics for calculating pK(a)s in proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The conserved, buried aspartic acid in oxidized Escherichia coli thioredoxin has a pKa of 7.5. Its titration produces a related shift in global stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
pKa calculations for class A beta-lactamases: methodological and mechanistic implications
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Experimental pK(a) values of buried residues: analysis with continuum methods and role of water penetration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tanford-Kirkwood electrostatics for protein modeling.
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Self-consistent field approach to protein structure and stability. I: pH dependence of electrostatic contribution
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A self-consistent, microenvironment modulated screened coulomb potential approximation to calculate pH-dependent electrostatic effects in proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An empirical model for electrostatic interactions in proteins incorporating multiple geometry‐dependent dielectric constants
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of hydrophobic microenvironments in modulating pKa shifts in proteins.
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Charge-charge interactions are key determinants of the pK values of ionizable groups in ribonuclease Sa (pI=3.5) and a basic variant (pI=10.2).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
pK values of histidine residues in ribonuclease Sa: effect of salt and net charge.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Surface electrostatic interactions contribute little of stability of barnase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The effect of net charge on the solubility, activity, and stability of ribonuclease Sa
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Engineering a thermostable protein via optimization of charge-charge interactions on the protein surface
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rational Modification of Protein Stability by the Mutation of Charged Surface Residues†
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insensitivity of perturbed carboxyl pK(a) values in the ovomucoid third domain to charge replacement at a neighboring residue
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Theoretical and experimental analysis of ionization equilibria in ovomucoid third domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Salt effects on ionization equilibria of histidines in myoglobin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hydrogen bonds and the pH dependence of ovomucoid third domain stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Histidine-aromatic interactions in barnase. Elevation of histidine pKa and contribution to protein stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Contribution of surface salt bridges to protein stability: guidelines for protein engineering
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
pKaValues and the pH Dependent Stability of the N-Terminal Domain of L9 as Probes of Electrostatic Interactions in the Denatured State. Differentiation between Local and Nonlocal Interactions†
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
pKA values of carboxyl groups in the native and denatured states of barnase: the pKA values of the denatured state are on average 0.4 units lower than those of model compounds
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Site-specific contributions to the pH dependence of protein stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Experimental measurement of the effective dielectric in the hydrophobic core of a protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High apparent dielectric constants in the interior of a protein reflect water penetration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
pH-dependent processes in proteins.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2980002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0076-6879(04)80002-8
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PubMed publication ID
15051331
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