(Q28253849)

1

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Y Okamura-Oho

2

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Y Mito

3

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S Nagafuchi

4

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M Yamada

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

14 November 1997

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published in

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volume

272

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issue

46

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page(s)

29238-42

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cites work

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Human ICE/CED-3 protease nomenclature

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

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Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

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Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution

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DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis

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DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

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Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p

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Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA)

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Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

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Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

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Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro

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Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA)

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Bcl-2 relieves the trans-repressive function of the glucocorticoid receptor and inhibits the activation of CPP32-like cysteine proteases

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Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

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Abnormal gene product identified in hereditary dentatorubral-pallidoluysian atrophy (DRPLA) brain

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Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.

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The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

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ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis

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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

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Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence

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Proteolysis of fodrin (non-erythroid spectrin) during apoptosis.

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Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

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