(Q28255422)

English

Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau

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scholarly article

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Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau (English)

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phosphorylation

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based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

Volker Meske

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Frank Albert

2

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Thomas Georg Ohm

3

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language of work or name

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publication date

4 January 2008

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Journal of Biological Chemistry

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283

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100-9

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1

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Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Post-translational modifications of tau protein in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Association of diabetes mellitus and dementia: the Rotterdam Study.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Diabetes mellitus and the risk of dementia: The Rotterdam Study.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

The risk of dementia among persons with diabetes mellitus: a population-based cohort study.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Peripheral hyperinsulinemia promotes tau phosphorylation in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Role of serine/threonine protein phosphatase in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Modulation of the phosphorylation state of tau in situ: the roles of calcium and cyclic AMP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Role of mTOR in the degradation of IRS-1: regulation of PP2A activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Prolactin activates mammalian target-of-rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 in lymphoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Alpha 4 associates with protein phosphatases 2A, 4, and 6

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

The mTOR pathway in the control of protein synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Rapamycin partially prevents insulin resistance induced by chronic insulin treatment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Specificity of the polycation-stimulated (type-2A) and ATP, Mg-dependent (type-1) protein phosphatases toward substrates phosphorylated by P34cdc2 kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Regulation of phosphorylation of tau by protein kinases in rat brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcmeurin and phosphatase-2A

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704292200

21 January 2018

Identifiers

10.1074/JBC.M704292200

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