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P2X receptors as cell-surface ATP sensors in health and disease
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title
P2X receptors as cell-surface ATP sensors in health and disease
(English)
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author name string
Baljit S Khakh
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R Alan North
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language of work or name
English
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publication date
3 August 2006
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published in
Nature
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volume
442
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page(s)
527-32
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issue
7102
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cites work
The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves
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Extracellular metabolism of ATP and other nucleotides
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Molecular physiology of P2X receptors
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A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP
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New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
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P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels
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Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize
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Subunit Arrangement in P2X Receptors
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ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists
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An intersubunit zinc binding site in rat P2X2 receptors
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Refined structure of the nicotinic acetylcholine receptor at 4A resolution
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The structure and function of glutamate receptor ion channels
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Pharmacological and biophysical properties of the human P2X5 receptor
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Ion permeation and block of P2X(2) purinoceptors: single channel recordings
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Contribution of calcium ions to P2X channel responses.
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Structural changes during ion channel gating
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Structure and gating mechanism of the acetylcholine receptor pore
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Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds.
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Time-resolved measurement of state-specific P2X2 ion channel cytosolic gating motions.
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Nicotinic acetylcholine receptor at 4.6 A resolution: transverse tunnels in the channel wall.
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Identification of a trafficking motif involved in the stabilization and polarization of P2X receptors
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Identification of a non-canonical tyrosine-based endocytic motif in an ionotropic receptor
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Control of P2X(2) channel permeability by the cytosolic domain
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Cutting edge: the nucleotide receptor P2X7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide
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Proteomic and functional evidence for a P2X7 receptor signalling complex
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Fe65 interacts with P2X2 subunits at excitatory synapses and modulates receptor function
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Distinct Localization of P2X receptors at excitatory postsynaptic specializations
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ATP receptor-mediated synaptic currents in the central nervous system
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Coordinate release of ATP and GABA at in vitro synapses of lateral hypothalamic neurons.
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Synaptic corelease of ATP and GABA in cultured spinal neurons
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Role for P2X receptors in long-term potentiation.
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Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors
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P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine
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Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses
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ATP receptor-mediated enhancement of fast excitatory neurotransmitter release in the brain.
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ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord.
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ATP modulation of excitatory synapses onto interneurons
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Action potential-independent release of glutamate by Ca2+ entry through presynaptic P2X receptors elicits postsynaptic firing in the brainstem autonomic network
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ATP excites interneurons and astrocytes to increase synaptic inhibition in neuronal networks.
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Direct excitation of inhibitory interneurons by extracellular ATP mediated by P2Y1 receptors in the hippocampal slice.
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Stimulation-dependent release of adenosine triphosphate from hippocampal slices
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Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy.
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ATP mediates rapid microglial response to local brain injury in vivo
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P2X7 receptor inhibition improves recovery after spinal cord injury
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Adenosine and ATP link PCO2 to cortical excitability via pH.
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P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
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BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
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Observations on the algogenic actions of adenosine compounds on the human blister base preparation
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ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia.
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A P2X purinoceptor expressed by a subset of sensory neurons
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Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons
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Electrophysiological properties of P2X-purinoceptors in rat superior cervical, nodose and guinea-pig coeliac neurones.
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Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice
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Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors
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A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.
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Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat.
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Enteric P2X receptors as potential targets for drug treatment of the irritable bowel syndrome
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7 January 2021
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ATP signaling is crucial for communication from taste buds to gustatory nerves
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On the peripheral and central chemoreception and control of breathing: an emerging role of ATP.
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ATP is a mediator of chemosensory transduction in the central nervous system
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ATP induces nucleotide permeability in rat mast cells
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Extracellular ATP: effects, sources and fate
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The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)
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Altered cytokine production in mice lacking P2X(7) receptors
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Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response
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Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption
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Pore dilation of neuronal P2X receptor channels
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N-methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P2X(7) receptors
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Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes
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Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
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Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells
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Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice
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Functional characterization of a P2X receptor from Schistosoma mansoni
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Identifiers
DOI
10.1038/NATURE04886
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stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
878979
Dimensions Publication ID
1041626860
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OpenCitations bibliographic resource ID
878979
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
878979
PubMed ID
16885977
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
878979
ResearchGate publication ID
6900779
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Springer Nature article ID
10.1038/nature04886
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