(Q34431207)

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A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. (English)

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2 August 2017

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neuropathic pain

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chronic neuropathic pain

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Timothy J Brennan

object named as

Timothy J Brennan

6

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author name string

Michael F Jarvis

1

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2 August 2017

Edward C Burgard

2

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2 August 2017

Steve McGaraughty

3

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2 August 2017

Prisca Honore

4

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2 August 2017

Kevin Lynch

5

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2 August 2017

Alberto Subieta

7

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2 August 2017

Tim Van Biesen

8

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2 August 2017

Jayne Cartmell

9

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2 August 2017

Bruce Bianchi

10

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2 August 2017

Wende Niforatos

11

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2 August 2017

Karen Kage

12

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2 August 2017

Haixia Yu

13

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2 August 2017

Joe Mikusa

14

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2 August 2017

Carol T Wismer

15

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2 August 2017

Chang Z Zhu

16

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2 August 2017

Katharine Chu

17

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2 August 2017

Chih-Hung Lee

18

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2 August 2017

Andrew O Stewart

19

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2 August 2017

James Polakowski

20

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2 August 2017

Bryan F Cox

21

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2 August 2017

Elizabeth Kowaluk

22

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2 August 2017

Michael Williams

23

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2 August 2017

James Sullivan

24

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2 August 2017

Connie Faltynek

25

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2 August 2017

language of work or name

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publication date

13 December 2002

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2 August 2017

Proceedings of the National Academy of Sciences of the United States of America

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2 August 2017

99

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Europe PubMed Central

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2 August 2017

26

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2 August 2017

17179-17184

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2 August 2017

The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

Purine and pyrimidine (P2) receptors as drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive eff

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

P2 purinergic receptors: modulation of cell function and therapeutic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

Molecular and functional characterization of human P2X(2) receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

In vivo pathway of thermal hyperalgesia by intrathecal administration of alpha,beta-methylene ATP in mouse spinal cord: involvement of the glutamate-NMDA receptor system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

2',3'-O-(2,4,6- trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP)--a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

Characterization of a rat model of incisional pain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

A P2X purinoceptor expressed by a subset of sensory neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

Observations on the algogenic actions of adenosine compounds on the human blister base preparation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

6 July 2018

Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

27 October 2018

Ectopic purinergic sensitivity develops at sites of chronic nerve constriction injury in rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

27 October 2018

Pharmacological characterization of recombinant human and rat P2X receptor subtypes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

27 October 2018

Immunocytochemical localization of P2X3 purinoceptors in sensory neurons in naive rats and following neuropathic injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

27 October 2018

The induction of pain: an integrative review.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

27 October 2018

Intrathecal metabotropic glutamate receptor antagonists do not decrease mechanical hyperalgesia in a rat model of postoperative pain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139289

27 October 2018

Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP)

1 reference

https://pubmed.ncbi.nlm.nih.gov/12482951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12482951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/12482951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP excites a subpopulation of rat dorsal horn neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/12482951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P2X receptor-mediated ionic currents in dorsal root ganglion neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12482951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/12482951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.252537299

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

2002PNAS...9917179J

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

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