(Q28257755)

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A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex

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A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex (English)

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crystal structure

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Timothy C. Umland

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Timothy C Umland

1

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author name string

Edith C Wolff

2

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Myung Hee Park

3

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David R Davies

4

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publication date

2 July 2004

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Journal of Biological Chemistry

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279

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27

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28697-705

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The archaebacterial hypusine-containing protein. Structural features suggest common ancestry with eukaryotic translation initiation factor 5A.

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Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation

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Cell cycle arrest in archaea by the hypusination inhibitor N(1)-guanyl-1,7-diaminoheptane

1 reference

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Inhibition of cell growth through inactivation of eukaryotic translation initiation factor 5A (eIF5A) by deoxyspergualin.

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Hypusine is required for a sequence-specific interaction of eukaryotic initiation factor 5A with postsystematic evolution of ligands by exponential enrichment RNA.

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Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes

1 reference

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Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase

1 reference

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Deoxyhypusine synthase generates and uses bound NADH in a transient hydride transfer mechanism

1 reference

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Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site

1 reference

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Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor

1 reference

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Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates

1 reference

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Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins

1 reference

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Processing of X-ray diffraction data collected in oscillation mode

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

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PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling

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Branched-chain and unsaturated 1,7-diaminoheptane derivatives as deoxyhypusine synthase inhibitors.

1 reference

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Crystal structures of eukaryotic translation initiation factor 5A from Methanococcus jannaschii at 1.8 A resolution

1 reference

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Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 A resolution

1 reference

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Crystal structure of hyperthermophilic archaeal initiation factor 5A: a homologue of eukaryotic initiation factor 5A (eIF-5A)

1 reference

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Deoxyhypusine synthase from tobacco. cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity

1 reference

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Evidence for general occurrence of homospermidine in plants and its supposed origin as by-product of deoxyhypusine synthase

1 reference

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21 January 2018

Molecular evolution by change of function. Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor protein

1 reference

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21 January 2018

Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase

1 reference

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21 January 2018

Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase

1 reference

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21 January 2018

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10.1074/JBC.M404095200

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