(Q28259812)

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Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes

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scholarly article

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Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes (English)

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5

object named as

Frances H Arnold

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Christopher D Snow

object named as

Christopher D Snow

2

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author name string

Mike M Y Chen

1

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Christina L Vizcarra

3

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Stephen L Mayo

4

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language of work or name

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publication date

April 2012

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Protein Engineering Design and Selection

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25

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4

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171-8

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Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Computational tools for designing and engineering biocatalysts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Plant cytochromes P450: tools for pharmacology, plant protection and phytoremediation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Progress towards the easier use of P450 enzymes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Rational re-design of the substrate binding site of flavocytochrome P450 BM3

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Structural aspects of ligand binding to and electron transfer in bacterial and fungal P450s

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

The catalytic pathway of cytochrome p450cam at atomic resolution

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Computationally designed libraries of fluorescent proteins evaluated by preservation and diversity of function

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Uncoupling oxygen transfer and electron transfer in the oxygenation of camphor analogues by cytochrome P450-CAM. Direct observation of an intermolecular isotope effect for substrate C-H activation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Combining computational and experimental screening for rapid optimization of protein properties

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Complex reactions catalyzed by cytochrome P450 enzymes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

User-friendly algorithms for estimating completeness and diversity in randomized protein-encoding libraries

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Combinatorial cassette mutagenesis as a probe of the informational content of protein sequences

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Pivotal role of water in the mechanism of P450BM-3

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Structure and chemistry of cytochrome P450.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Engineering cytochrome P450 BM-3 for oxidation of polycyclic aromatic hydrocarbons

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Conformational diversity and computational enzyme design

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

P450 monooxygenase in biotechnology. I. Single-step, large-scale purification method for cytochrome P450 BM-3 by anion-exchange chromatography

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Molecular dynamics study of time-correlated protein domain motions and molecular flexibility: cytochrome P450BM-3

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

P450 fingerprinting method for rapid discovery of terpene hydroxylating P450 catalysts with diversified regioselectivity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Cytochrome P450 monooxygenases: perspectives for synthetic application

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Evolutionary history of a specialized p450 propane monooxygenase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Hydrocarbon hydroxylation by cytochrome P450 enzymes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Use of phage display and transition-state analogs to select enzyme variants with altered catalytic properties: glutathione transferase as an example

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Structure-based combinatorial protein engineering (SCOPE).

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1093/PROTEIN/GZS004

Identifiers

10.1093/PROTEIN/GZS004

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