(Q28261381)

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Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system

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Europe PubMed Central

Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system (English)

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author name string

Michael R Lieber

1

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Haihui Lu

2

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Jiafeng Gu

3

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Klaus Schwarz

4

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language of work or name

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publication date

January 2008

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18

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125-33

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1

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

DNA-PK autophosphorylation facilitates Artemis endonuclease activity

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

DNA joint dependence of pol X family polymerase action in nonhomologous end joining

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts.

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

Structural insight into the substrate specificity of DNA Polymerase mu

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

Yeast DNA ligase IV mediates non-homologous DNA end joining

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

DNA ligase IV from HeLa cell nuclei

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

IgH class switching and translocations use a robust non-classical end-joining pathway

1 reference

https://api.crossref.org/works/10.1038/CR.2007.108

21 April 2017

A biochemically defined system for mammalian nonhomologous DNA end joining

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Processing of 3'-phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Polymerase mu is a DNA-directed DNA/RNA polymerase

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

DNA polymerase lambda, a novel DNA repair enzyme in human cells.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

DNA ligases: structure, reaction mechanism, and function

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Length-dependent binding of human XLF to DNA and stimulation of XRCC4.DNA ligase IV activity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

V(D)J recombination: RAG proteins, repair factors, and regulation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Ig class switching: targeting the recombinational mechanism

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

An evolutionarily conserved target motif for immunoglobulin class-switch recombination

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

DNA double strand break repair and chromosomal translocation: lessons from animal models

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Telomeres and chromosome instability

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Rag mutations reveal robust alternative end joining

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

21 January 2018

Loading of the nonhomologous end joining factor, Ku, on protein-occluded DNA ends

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

7 January 2021

based on heuristic

inferred from DOI database lookup

A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

7 January 2021

based on heuristic

inferred from DOI database lookup

Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence that base stacking potential in annealed 3' overhangs determines polymerase utilization in yeast nonhomologous end joining

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

7 January 2021

based on heuristic

inferred from DOI database lookup

Evolution of the immunoglobulin heavy chain class switch recombination mechanism

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

7 January 2021

based on heuristic

inferred from DOI database lookup

The influence of transcriptional orientation on endogenous switch region function

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.108

7 January 2021

based on heuristic

inferred from DOI database lookup

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