(Q28268434)

English

Preclinical pharmacokinetic and pharmacodynamic evaluation of novel anticancer agents, ON01910.Na (Rigosertib, Estybon™) and ON013105, for brain tumor chemotherapy

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Preclinical pharmacokinetic and pharmacodynamic evaluation of novel anticancer agents, ON01910.Na (Rigosertib, Estybon™) and ON013105, for brain tumor chemotherapy (English)

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pharmacodynamics

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Silpa Nuthalapati

1

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Qingyu Zhou

2

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Ping Guo

3

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Hua Lv

4

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Stephen Cosenza

5

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M V Ramana Reddy

6

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E Premkumar Reddy

7

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James M Gallo

8

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language of work or name

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publication date

September 2012

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Pharmaceutical Research

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29

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9

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2499-511

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ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Phase I study of ON 01910.Na, a novel modulator of the Polo-like kinase 1 pathway, in adult patients with solid tumors.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Styryl sulfonyl compounds inhibit translation of cyclin D1 in mantle cell lymphoma cells

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Design, synthesis, and biological evaluation of (E)-styrylbenzylsulfones as novel anticancer agents

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Evaluation of novel cell cycle inhibitors in mantle cell lymphoma

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Malignant gliomas in adults

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: implication of tumor vascularization

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

The effect of cyclin D expression on cell proliferation in human gliomas.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

New colorimetric cytotoxicity assay for anticancer-drug screening

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Fluid Shifts and Other Factors Affecting Plasma Protein Binding of Prednisolone by Equilibrium Dialysis

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Application of a liquid chromatography-tandem mass spectrometry (LC/MS/MS) method to the pharmacokinetics of ON01910 in brain tumor-bearing mice

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Preclinical pharmacokinetics and in vitro activity of ON 01910.Na, a novel anti-cancer agent

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Blood-brain barrier interfaces and brain tumors

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Medicinal chemical properties of successful central nervous system drugs

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Microvascular abnormalities in virally-induced canine brain tumors. Structural bases for altered blood-brain barrier function

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

The vasculature of experimental brain tumours. Part 1. A sequential light and electron microscope study of angiogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Quantitative measurements of capillary transport in human brain tumors by computed tomography

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Pharmacokinetic model-predicted anticancer drug concentrations in human tumors

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0780-Y

21 January 2018

Ki-67 Staining as a Means to Simplify Analysis of Tumor Cell Proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of nonlinear tissue distribution of quinidine in rats by physiologically based pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/22678771

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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