(Q28271104)

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ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1

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ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1 (English)

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Dual specificity phosphatase 6

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GOA release 2020-03-11

Protein tyrosine phosphatase, receptor type, R

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GOA release 2020-03-11

Mitogen-activated protein kinase 1

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GOA release 2020-03-11

author name string

Céline Tárrega

1

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Pablo Ríos

2

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Rocío Cejudo-Marín

3

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Carmen Blanco-Aparicio

4

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Lieke van den Berk

5

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Jan Schepens

6

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Wiljan Hendriks

7

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Lydia Tabernero

8

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Rafael Pulido

9

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language of work or name

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publication date

11 November 2005

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Journal of Biological Chemistry

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280

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45

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37885-94

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New insights into the control of MAP kinase pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Mitogen-activated protein kinases: specific messages from ubiquitous messengers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Docking domains and substrate-specificity determination for MAP kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Molecular recognitions in the MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

The structure of mitogen-activated protein kinase p38 at 2.1-A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Crystal structure of JNK3: a kinase implicated in neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

A conserved docking motif in MAP kinases common to substrates, activators and regulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

A Bipartite Mechanism for ERK2 Recognition by Its Cognate Regulators and Substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

The osmoregulatory pathway represses mating pathway activity in Saccharomyces cerevisiae: isolation of a FUS3 mutant that is insensitive to the repression mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

How MAP kinases are regulated

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Extracellular signals and scores of phosphatases: all roads lead to MAP kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Nonreceptor tyrosine phosphatases in cellular signaling: regulation of mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Protein tyrosine phosphatases in the human genome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Multiple regions of MAP kinase phosphatase 3 are involved in its recognition and activation by ERK2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Modular structure of a docking surface on MAPK phosphatases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

A cholesterol-regulated PP2A/HePTP complex with dual specificity ERK1/2 phosphatase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Biochemical and biological functions of the N-terminal, noncatalytic domain of extracellular signal-regulated kinase 2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Molecular determinants of substrate recognition in hematopoietic protein-tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Differential interaction of the tyrosine phosphatases PTP-SL, STEP and HePTP with the mitogen-activated protein kinases ERK1/2 and p38alpha is determined by a kinase specificity sequence and influenced by reducing agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Involvement of the activation loop of ERK in the detachment from cytosolic anchoring

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504366200

21 January 2018

Identifiers

10.1074/JBC.M504366200

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