(Q28272786)

English

Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

0 references

0 references

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Emanuela Tolosano

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

author name string

Jason Patrick Day

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Harrison Phillips

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Bryan Slootsky

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

language of work or name

0 references

publication date

1 February 2016

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Journal of Neuroinflammation

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

13

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1

0 references

26

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

20 March 2017

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

20 March 2017

Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

20 March 2017

Hemopexin: structure, function, and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

20 March 2017

Iba1 is an actin-cross-linking protein in macrophages/microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

20 March 2017

Evidence for the localization of haemopexin immunoreactivity in neurones in the human brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

20 March 2017

Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

20 March 2017

Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

20 March 2017

Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

20 March 2017

Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Role of PGE₂ EP1 receptor in intracerebral hemorrhage-induced brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

A role for hemopexin in oligodendrocyte differentiation and myelin formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Molecular pathophysiology of cerebral hemorrhage: secondary brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Neuroprotective role of haptoglobin after intracerebral hemorrhage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Taking advantage of the systemic immune system to cure brain diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Heme degradation and vascular injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Heme regulatory motifs in heme oxygenase-2 form a thiol/disulfide redox switch that responds to the cellular redox state.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Heme-hemopexin complex attenuates neuronal cell death and stroke damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Haemopexin affects iron distribution and ferritin expression in mouse brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

CD163, a marker of perivascular macrophages, is up-regulated by microglia in simian immunodeficiency virus encephalitis after haptoglobin-hemoglobin complex stimulation and is suggestive of breakdown of the blood-brain barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Methemoglobin--it's not just blue: a concise review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Neuroprotective effect of exogenous microglia in global brain ischemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Microglia provide neuroprotection after ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Heme and iron metabolism: role in cerebral hemorrhage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Iron metabolism in the reticuloendothelial system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Intracellular signaling in M-CSF-induced microglia activation: role of Iba1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Microglia as neuroprotective, immunocompetent cells of the CNS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Structure-function relationships in heme-proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Adaptive responses of the endothelium to stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Heme oxygenase-2 is neuroprotective in cerebral ischemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Adenovirus-mediated gene transfer of glial cell line-derived neurotrophic factor prevents ischemic brain injury after transient middle cerebral artery occlusion in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

29 September 2017

Iron and iron-handling proteins in the brain after intracerebral hemorrhage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

2 June 2018

Heme oxygenase-2 is a hemoprotein and binds heme through heme regulatory motifs that are not involved in heme catalysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

2 June 2018

The heme oxygenase system: a regulator of second messenger gases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

2 June 2018

Heme oxygenase-1 and heat shock protein 70 induction in glia and neurons throughout rat brain after experimental intracerebral hemorrhage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

2 June 2018

Exchange of heme among hemoglobins and between hemoglobin and albumin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

2 June 2018

Pro-oxidant and cytotoxic effects of circulating heme.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Mechanism of low-density lipoprotein oxidation by hemoglobin-derived iron.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Identification of the receptor scavenging hemopexin-heme complexes.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Uptake and internalization of exogenous apolipoprotein E3 by cultured human central nervous system neurons.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Cerebral heme oxygenase 1 and 2 spatial distribution is modulated following injury from hypoxia-ischemia and middle cerebral artery occlusion in rats.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Differential expression of heme oxygenase-1 in cultured cortical neurons and astrocytes determined by the aid of a new heme oxygenase antibody. Response to oxidative stress

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Induction of heme oxygenase-1 (HO-1) after traumatic brain injury in the rat.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Expression and regulation of heme oxygenase isozymes in the developing mouse cortex.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer’s disease1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is part of a series of reviews on “Causes and Consequences of Oxidati

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Gene expression profiles of heme oxygenase isoforms in the rat brain.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Effect of targeted deletion of the heme oxygenase-2 gene on hemoglobin toxicity in the striatum

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Citicoline treatment for experimental intracerebral hemorrhage in mice.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Attenuation of oxidative injury after induction of experimental intracerebral hemorrhage in heme oxygenase-2 knockout mice.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Efficient three-drug cocktail for disease induced by mutant superoxide dismutase

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Intracerebral haemorrhage: a need for more data and new research directions

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase

1 reference

https://api.crossref.org/works/10.1186%2FS12974-016-0490-1

21 January 2018

Heme Oxygenase-2 Protects against Lipid Peroxidation-Mediated Cell Loss and Impaired Motor Recovery after Traumatic Brain Injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736638

27 November 2018

The cellular reactions to experimental intracerebral hemorrhage

1 reference

https://pubmed.ncbi.nlm.nih.gov/26831741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function

1 reference

https://pubmed.ncbi.nlm.nih.gov/26831741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/26831741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalytically inactive heme oxygenase-2 mutant is cytoprotective

1 reference

https://pubmed.ncbi.nlm.nih.gov/26831741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

1 reference

https://pubmed.ncbi.nlm.nih.gov/26831741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S12974-016-0490-1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12974-016-0490-1

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831741%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q28272786&oldid=2177573587"