(Q28273012)

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Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents

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Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents (English)

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1 reference

based on heuristic

4

object named as

Jan Albrecht

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Marta Obara-Michlewska

3

object named as

Marta Obara-Michlewska

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1

object named as

Monika Szeliga

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author name string

Agata Zgrzywa

2

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language of work or name

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publication date

November 2012

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Journal of Neurochemistry

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123

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3

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428-36

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Identification of two human glutaminase loci and tissue-specific expression of the two related genes.

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O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines

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Control of mammalian gene expression by amino acids, especially glutamine

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MGMT activity, promoter methylation and immunohistochemistry of pretreatment and recurrent malignant gliomas: a comparative study on astrocytoma and glioblastoma

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Methylation-Related Chromatin Structure Is Associated with Exclusion of Transcription Factors from and Suppressed Expression of the O-6-Methylguanine DNA Methyltransferase Gene in Human Glioma Cell Lines

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Regulation of glutaminase activity and glutamine metabolism

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Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

1 reference

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In vitro drug response and molecular markers associated with drug resistance in malignant gliomas.

1 reference

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Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene

1 reference

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MGMT gene silencing and benefit from temozolomide in glioblastoma

1 reference

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O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

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Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

1 reference

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MGMT hypermethylation: a prognostic foe, a predictive friend

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Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study.

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MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents

1 reference

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Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide

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WNT signaling pathway and stem cell signaling network

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Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

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Novel mechanism whereby nuclear factor kappaB mediates DNA damage repair through regulation of O(6)-methylguanine-DNA-methyltransferase

1 reference

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O(6) -methylguanine-DNA methyltransferase (MGMT) promoter methylation and low MGMT-encoded protein expression as prognostic markers in glioblastoma patients treated with biodegradable carmustine wafer implants after initial surgery followed by radio

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Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas

1 reference

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Glutaminase: a multifaceted protein not only involved in generating glutamate.

1 reference

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Influence of O6-methylguanine-DNA methyltransferase activity on chloroethylnitrosourea chemotherapy in brain tumors.

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Application of antisense ribonucleic acid complementary to O6-methylguanine-deoxyribonucleic acid methyltransferase messenger ribonucleic acid for therapy of malignant gliomas

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Prognostic significance of O6-methylguanine-DNA methyltransferase protein expression in patients with recurrent glioblastoma treated with temozolomide

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The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins

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Nuclear localization of L-type glutaminase in mammalian brain

1 reference

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Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.

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Glutamine in neoplastic cells: focus on the expression and roles of glutaminases

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Lack of expression of the liver-type glutaminase (LGA) mRNA in human malignant gliomas.

1 reference

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21 January 2018

Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells.

1 reference

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21 January 2018

Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas

1 reference

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MGMT in primary and recurrent human glioblastomas after radiation and chemotherapy and comparison with p53 status and clinical outcome.

1 reference

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Effect of IFN-beta on human glioma cell lines with temozolomide resistance

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10.1111/J.1471-4159.2012.07917.X

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