(Q28274561)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22957941%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

LSD1 inhibition: a therapeutic strategy in cancer? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22957941%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22957941%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

James T Lynch

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22957941%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

William J Harris

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22957941%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

language of work or name

English

0 references

publication date

8 September 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22957941%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

12 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22957941%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22957941%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22957941%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

1239-1249

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22957941%20AND%20SRC:MED&resulttype=core&format=json

Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

12 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1517/14728222.2012.722206

Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25 A

21 April 2017

1 reference

https://api.crossref.org/works/10.1517/14728222.2012.722206

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

21 April 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Crystal structure of human histone lysine-specific demethylase 1 (LSD1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Crystal structure and mechanism of human lysine-specific demethylase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Histone demethylation by a family of JmjC domain-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Regulation of LSD1 histone demethylase activity by its associated factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

CORUM: the comprehensive resource of mammalian protein complexes--2009

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Coordinated histone modifications mediated by a CtBP co-repressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

High-resolution profiling of histone methylations in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Human histone demethylase LSD1 reads the histone code

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Functional interplay between histone demethylase and deacetylase enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Lysine methylation regulates E2F1-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

p53 is regulated by the lysine demethylase LSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Opposing LSD1 complexes function in developmental gene activation and repression programmes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Transrepressive function of TLX requires the histone demethylase LSD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Histone demethylase LSD1 regulates neural stem cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Gene expression changes associated with progression and response in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

A mechanism-based inactivator for histone demethylase LSD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

(Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Identification of cell-active lysine specific demethylase 1-selective inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Dimethylation of H3K4 by Set1 recruits the Set3 histone deacetylase complex to 5' transcribed regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

A gene atlas of the mouse and human protein-encoding transcriptomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

Mapping and analysis of chromatin state dynamics in nine human cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

S. pombe LSD1 Homologs Regulate Heterochromatin Propagation and Euchromatic Gene Transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.722206

10.1517/14728222.2012.722206

21 January 2018

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22957941%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22957941%20AND%20SRC:MED&resulttype=core&format=json