(Q53325167)

13 May 2018

title

Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells? (English)

1 reference

13 May 2018

1 reference

1

Tim C P Somervaille

1 reference

13 May 2018

author name string

Michael L Cleary

series ordinal

2

1 reference

13 May 2018

publication date

8 May 2010

1 reference

13 May 2018

International Journal of Hematology

published in

1 reference

13 May 2018

volume

91

1 reference

13 May 2018

issue

5

1 reference

13 May 2018

page(s)

735-741

1 reference

13 May 2018

Protein arginine-methyltransferase-dependent oncogenesis

cites work

1 reference

12 December 2020

Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

1 reference

12 December 2020

Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells

1 reference

12 December 2020

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

1 reference

12 December 2020

Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias

1 reference

12 December 2020

Gene expression profiling of pediatric acute myelogenous leukemia

1 reference

12 December 2020

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

1 reference

12 December 2020

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells

1 reference

12 December 2020

Menin critically links MLL proteins with LEDGF on cancer-associated target genes

1 reference

12 December 2020

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

1 reference

12 December 2020

Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner

1 reference

12 December 2020

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

1 reference

12 December 2020

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy.

1 reference

12 December 2020

Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions

1 reference

12 December 2020

AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML.

1 reference

12 December 2020

The MLL partial tandem duplication in acute myeloid leukaemia

1 reference

12 December 2020

Perspectives on clonogenic tumor cells, stem cells, and oncogenes

1 reference

12 December 2020

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

1 reference

12 December 2020

Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization

1 reference

12 December 2020

c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells.

1 reference

12 December 2020

K-Ras mutations and N-Ras mutations in childhood acute leukemias with or without mixed-lineage leukemia gene rearrangements.

1 reference

12 December 2020

Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells

1 reference

12 December 2020

Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression

1 reference

12 December 2020

A stem cell model of human tumor growth: implications for tumor cell clonogenic assays.

1 reference

12 December 2020

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.

1 reference

12 December 2020

Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells

1 reference

12 December 2020

Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.

1 reference

12 December 2020

Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal.

1 reference

12 December 2020

Oncogenic transcription factors in the human acute leukemias

1 reference

12 December 2020

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

1 reference

12 December 2020

Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics

1 reference

12 December 2020

The PHD fingers of MLL block MLL fusion protein-mediated transformation

1 reference

12 December 2020

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

1 reference

12 December 2020

Common mechanism for oncogenic activation of MLL by forkhead family proteins

1 reference

12 December 2020

Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors

1 reference

12 December 2020

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

1 reference

12 December 2020

Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.

1 reference

12 December 2020

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

1 reference

12 December 2020

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

1 reference

12 December 2020

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia

1 reference

12 December 2020

Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality

1 reference

12 December 2020

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

1 reference

12 December 2020

HOXA9 is required for survival in human MLL-rearranged acute leukemias

1 reference

12 December 2020

hDOT1L links histone methylation to leukemogenesis

1 reference

12 December 2020

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

1 reference

12 December 2020

Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance

1 reference

12 December 2020

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy

1 reference

12 December 2020

Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia

1 reference

12 December 2020

Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.

1 reference

12 December 2020

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

1 reference

12 December 2020

Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

1 reference

12 December 2020

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1 reference

12 December 2020

Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

1 reference

12 December 2020

PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors

1 reference

12 December 2020

MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.

1 reference

12 December 2020

Prognostically useful gene-expression profiles in acute myeloid leukemia.

1 reference

12 December 2020

Therapeutic targeting of MLL.

1 reference

12 December 2020

New insights to the MLL recombinome of acute leukemias

1 reference

12 December 2020

The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

1 reference

12 December 2020

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

1 reference

12 December 2020

Altered Hox expression and segmental identity in Mll-mutant mice

1 reference

12 December 2020

Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells

1 reference

12 December 2020

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

1 reference

12 December 2020

ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias

1 reference

12 December 2020

Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia

1 reference

12 December 2020

Modeling the initiation and progression of human acute leukemia in mice

1 reference

12 December 2020

1 reference

12 December 2020

The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10.

1 reference

12 December 2020

Proliferative state of blast cell progenitors in acute myeloblastic leukemia (AML).

1 reference

12 December 2020

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

1 reference

12 December 2020

Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein

1 reference

12 December 2020

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

1 reference

12 December 2020

10.1007/S12185-010-0579-8

Identifiers

DOI

1 reference

13 May 2018

1 reference

13 May 2018