(Q28284323)

English

Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy

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Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy (English)

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crystal structure

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1 reference

based on heuristic

inferred from title

2

object named as

Nathan P Manes

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author name string

Song-Gun Kim

1

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M Raafat El-Maghrabi

3

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Yong-Hwan Lee

4

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language of work or name

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publication date

3 February 2006

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Journal of Biological Chemistry

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281

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5

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2939-44

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6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme

1 reference

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21 January 2018

Evolution of a bifunctional enzyme: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

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21 January 2018

Heart 6-phosphofructo-2-kinase activation by insulin results from Ser-466 and Ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B.

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21 January 2018

Insulin and ischemia stimulate glycolysis by acting on the same targets through different and opposing signaling pathways

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21 January 2018

The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase

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21 January 2018

An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect

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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: suiting structure to need, in a family of tissue-specific enzymes.

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21 January 2018

Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene

1 reference

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21 January 2018

Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2)

1 reference

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21 January 2018

Identification and characterization of the hypoxia-responsive element of the human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene

1 reference

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21 January 2018

Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect

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21 January 2018

Tissue distribution of placenta-type 6-phosphofructo- 2-kinase/fructose-2,6-bisphosphatase

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21 January 2018

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase expression in rat brain during development

1 reference

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21 January 2018

Characterization of a human placental fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase

1 reference

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21 January 2018

The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate

1 reference

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Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

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21 January 2018

Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors.

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21 January 2018

On the Origin of Cancer Cells

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Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation

1 reference

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21 January 2018

Targeted disruption of inducible 6-phosphofructo-2-kinase results in embryonic lethality.

1 reference

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21 January 2018

Signal transduction to hypoxia-inducible factor 1

1 reference

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21 January 2018

Inhibition of tumor cell growth by a specific 6-phosphofructo-2-kinase inhibitor, N-bromoacetylethanolamine phosphate, and its analogues

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21 January 2018

Crystal structure of the rat liver fructose-2,6-bisphosphatase based on selenomethionine multiwavelength anomalous dispersion phases

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21 January 2018

Crystal structure of a trapped phosphoenzyme during a catalytic reaction

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21 January 2018

Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

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21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

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The CCP4 suite: programs for protein crystallography

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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On the computation of the fast rotation function.

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Improved methods for building protein models in electron density maps and the location of errors in these models

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21 January 2018

The crystal structure of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase reveals distinct domain homologies

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21 January 2018

A switch in the kinase domain of rat testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

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21 January 2018

Conformational changes: how small is big enough?

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21 January 2018

Raster3D Version 2.0. A program for photorealistic molecular graphics

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21 January 2018

Identifiers

10.1074/JBC.M511019200

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