(Q28285346)

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Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase

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Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase (English)

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Alzheimer's disease

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based on heuristic

inferred from title

phosphorylation

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author name string

J Z Wang

1

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Q Wu

2

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A Smith

3

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I Grundke-Iqbal

4

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K Iqbal

5

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language of work or name

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publication date

25 September 1998

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436

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28-34

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1

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

A protein factor essential for microtubule assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Tau protein function in living cells

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Calcium/calmodulin-dependent protein kinase II phosphorylates tau at Ser-262 but only partially inhibits its binding to microtubules

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

p42 map kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1Implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Protein kinase FA/GSK-3 phosphorylates tau on Ser235-Pro and Ser404-Pro that are abnormally phosphorylated in Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Modulation of GSK-3-catalyzed phosphorylation of microtubule-associated protein tau by non-proline-dependent protein kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Polyamines stimulate the activity of glycogen synthase (casein) kinase-1 from bovine kidney and different rat tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Assay of proteins in the presence of interfering materials

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Isolation of phosphoproteins by immobilized metal (Fe3+) affinity chromatography

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Microtubule Assembly in the Absence of Added Nucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Decoration and stabilization of intact, smooth-walled microtubules with microtubule-associated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Application of synthetic phospho- and unphospho- peptides to identify phosphorylation sites in a subregion of the tau molecule, which is modified in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Immunological and conformation characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Protein kinase C and calcium/calmodulin-dependent protein kinase II phosphorylate three-repeat and four-repeat tau isoforms at different rates.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Phosphorylation of tau by proline-directed protein kinase (p34cdc2/p58cyclin A) decreases tau-induced microtubule assembly and antibody SMI33 reactivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Identification of the ATP.Mg-dependent protein phosphatase activator (FA) as a synapsin I kinase that inhibits cross-linking of synapsin I with brain microtubules

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2898%2901090-4

7 January 2021

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