(Q28286115)

Polymorphic drug oxidation: pharmacokinetic basis and comparison of experimental indices

21 January 2018

1 reference

Backtracking booze with Bayes--the retrospective interpretation of blood alcohol data

21 January 2018

1 reference

Commentary: a physiological approach to hepatic drug clearance

21 January 2018

1 reference

Severe hypoxemia and liver disease

21 January 2018

1 reference

Sense and nonsense in the prediction of drug-drug interactions

21 January 2018

1 reference

Utility of metabolic stability screening: comparison of in vitro and in vivo clearance

31 March 2020

1 reference

An evaluation of the in vitro metabolism data for predicting the clearance and drug-drug interaction potential of CYP2C9 substrates

31 March 2020

1 reference

'In silico' simulations to assess the 'in vivo' consequences of 'in vitro' metabolic drug-drug interactions

31 March 2020

1 reference

Simulation of clinical trials

31 March 2020

1 reference

Computer simulation of a clinical trial as an aid to teaching the concept of statistical significance

31 March 2020

1 reference

Clinical trial experience by simulation: a workshop report

31 March 2020

1 reference

Sensitivity of indirect metrics for assessing "rate" in bioequivalence studies--moving the "goalposts" or changing the "game".

31 March 2020

1 reference

Caffeine urinary metabolite ratios as markers of enzyme activity: a theoretical assessment.

31 March 2020

1 reference

Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling

31 March 2020

1 reference

The Bayesian population approach to physiological toxicokinetic-toxicodynamic models--an example using the MCSim software

31 March 2020

1 reference

Analysis of solvent central nervous system toxicity and ethanol interactions using a human population physiologically based kinetic and dynamic model

31 March 2020

1 reference

Incorporating measures of variability and uncertainty into the prediction of in vivo hepatic clearance from in vitro data

31 March 2020

1 reference

Statins and the risk of idiopathic venous thromboembolism

31 March 2020

1 reference

More efficient clinical trials through use of scientific model-based statistical tests

31 March 2020

1 reference

Power, selection bias and predictive performance of the Population Pharmacokinetic Covariate Model

31 March 2020

1 reference

Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

31 March 2020

1 reference

Prediction of hepatic metabolic clearance: comparison and assessment of prediction models

31 March 2020

1 reference

Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

31 March 2020

1 reference

Kinetic values for mechanism-based enzyme inhibition: assessing the bias introduced by the conventional experimental protocol.

31 March 2020

1 reference

Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children

31 March 2020

1 reference

Prediction of in vivo drug clearance from in vitro data. II: potential inter-ethnic differences

31 March 2020

1 reference

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

31 March 2020

1 reference

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

31 March 2020

1 reference

Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance

31 March 2020

1 reference

Changes in liver volume from birth to adulthood: a meta-analysis.

31 March 2020

1 reference

Effect of food intake on cardiovascular control in patients with impaired autonomic function

31 March 2020

1 reference

Regulation of intestinal blood flow

31 March 2020

1 reference

The hemodynamic status of preascitic cirrhosis: an evaluation under steady-state conditions and after postural change

31 March 2020

1 reference

In silico prediction of aqueous solubility, human plasma protein binding and volume of distribution of compounds from calculated pKa and AlogP98 values

31 March 2020

1 reference

Application of in silico approaches to predicting drug--drug interactions

31 March 2020

1 reference

Structural characteristics of human P450s involved in drug metabolism: QSARs and lipophilicity profiles

31 March 2020

1 reference

Protein binding predictions in infants

31 March 2020

1 reference

Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability

31 March 2020

1 reference

Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling.

31 March 2020

1 reference

A review and assessment of potential sources of ethnic differences in drug responsiveness

31 March 2020

1 reference

Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat

31 March 2020

1 reference

A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy

31 March 2020

1 reference

No ethnic difference between Caucasian and Japanese hepatic samples in the expression frequency of CYP3A5 and CYP3A7 proteins

31 March 2020

1 reference

Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2

31 March 2020

1 reference

The use of mechanistic DM-PK-PD modelling to assess the power of pharmacogenetic studies -CYP2C9 and warfarin as an example

31 March 2020

1 reference

Database analyses for the prediction of in vivo drug-drug interactions from in vitro data

31 March 2020

1 reference

Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA.

31 March 2020

1 reference

Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner.

31 March 2020

1 reference