(Q48463862)

11 February 2018

title

Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling (English)

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11 February 2018

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Shiran MR

1

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11 February 2018

Proctor NJ

2

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11 February 2018

Howgate EM

3

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11 February 2018

Rowland-Yeo K

4

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11 February 2018

Tucker GT

5

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11 February 2018

Rostami-Hodjegan A

6

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11 February 2018

language of work or name

English

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publication date

1 July 2006

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11 February 2018

published in

Xenobiotica

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11 February 2018

volume

36

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11 February 2018

issue

7

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11 February 2018

page(s)

567-580

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11 February 2018

https://api.crossref.org/works/10.1080%2F00498250600761662

1 reference

Pharmacokinetics and bioavailability of omeprazole after single and repeated oral administration in healthy subjects

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Predicting toxicokinetic parameters in humans from toxicokinetic data acquired from three small mammalian species

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Caffeine renal clearance and urine caffeine concentrations during steady state dosing. Implications for monitoring caffeine intake during sports events

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Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

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Interspecies pharmacokinetic scaling and the evolutionary-comparative paradigm

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Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine

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Fluoxetine inhibits the metabolism of tolterodine-pharmacokinetic implications and proposed clinical relevance

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Correlation of plasma clearance of 54 extensively metabolized drugs between humans and rats: mean allometric coefficient of 0.66.

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The potential for CYP2D6 inhibition screening using a novel scintillation proximity assay-based approach

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The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine

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Interspecies scaling of cimetidine-theophylline pharmacokinetic interaction: interspecies scaling in pharmacokinetic interactions.

21 January 2018

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Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

21 January 2018

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Comparative single-dose kinetics and dynamics of lorazepam, alprazolam, prazepam, and placebo

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Pharmacokinetics of oral cyclosporin A (Sandimmun) in healthy subjects

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Biotransformation of caffeine by cDNA-expressed human cytochromes P-450.

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Effect of caffeine on clozapine pharmacokinetics in healthy volunteers

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Propofol decreases the clearance of midazolam by inhibiting CYP3A4: an in vivo and in vitro study.

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Pharmacokinetics and bioavailability of midazolam in man

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In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

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Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

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Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability

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Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil

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Prediction of in vivo drug clearance from in vitro data. II: potential inter-ethnic differences

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Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers

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Influence of menstrual cycle and gender on alprazolam pharmacokinetics

21 January 2018

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Physiologic and temporal variation in hepatic elimination of midazolam.

21 January 2018

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Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs.

21 January 2018

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Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

21 January 2018

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Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs

21 January 2018

1 reference

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Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C91 heterozygotes.

21 January 2018

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Prediction of drug clearance in humans from laboratory animals based on body surface area

21 January 2018

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Fluvoxamine inhibits the CYP2C9 catalyzed biotransformation of tolbutamide.

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Interspecies scaling: predicting oral clearance in humans.

21 January 2018

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Prediction of clearance in humans from in vitro human liver microsomes and allometric scaling. A comparative study of the two approaches

21 January 2018

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Interspecies scaling: a comparative study for the prediction of clearance and volume using two or more than two species

21 January 2018

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Interspecies scaling: predicting clearance of drugs in humans. Three different approaches

21 January 2018

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Interspecies scaling: predicting pharmacokinetic parameters of antiepileptic drugs in humans from animals with special emphasis on clearance.

21 January 2018

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The pharmacokinetic principles behind scaling from preclinical results to phase I protocols

21 January 2018

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Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates

21 January 2018

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Disposition of cyclosporine after intravenous and multi-dose oral administration in cats

21 January 2018

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Gender-dependent racial difference in disposition of cyclosporine among healthy African American and white volunteers

21 January 2018

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Failure of ‘therapeutic’ doses of beta-adrenoceptor antagonists to alter the disposition of tolbutamide and lignocaine

21 January 2018

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Physiologically based modelling of inhibition of metabolism and assessment of the relative potency of drug and metabolite: dextromethorphan vs. dextrorphan using quinidine inhibition

21 January 2018

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Pharmacogenetics of asthma

21 January 2018

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The effects of age and renal and hepatic impairment on the pharmacokinetics of sildenafil

21 January 2018

1 reference

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Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance

21 January 2018

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Fentanyl inhibits metabolism of midazolam: competitive inhibition of CYP3A4 in vitro.

21 January 2018

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Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

21 January 2018

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Cyclosporin A pharmacokinetics and efficacy in the treatment of atopic dermatitis in dogs

21 January 2018

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Cyclosporine pharmacokinetics and pharmacodynamics in African American and white subjects

21 January 2018

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Intravenous and oral clozapine pharmacokinetics, pharmacodynamics, and concentration-effect relations: acute tolerance.

21 January 2018

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Co-administration of ciprofloxacin and cyclosporin: lack of evidence for a pharmacokinetic interaction

21 January 2018

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A novel model for prediction of human drug clearance by allometric scaling

21 January 2018

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A mathematical description of the functionality of correction factors used in allometry for predicting human drug clearance

21 January 2018

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Accuracy of allometrically predicted pharmacokinetic parameters in humans: role of species selection.

21 January 2018

1 reference

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Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

21 January 2018

1 reference

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CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5'-promoter region polymorphism

21 January 2018

1 reference

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Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver

21 January 2018

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Prediction of hepatic metabolic clearance: comparison and assessment of prediction models

21 January 2018

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In-vivo and in-vitro dextromethorphan metabolism in SD and DA rat. An animal model of the debrisoquine-type polymorphic oxidation in man.

21 January 2018

1 reference

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10.1080/00498250600761662

21 January 2018

Identifiers

DOI

1 reference

11 February 2018

1 reference

11 February 2018