(Q28288758)

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The state of the prion

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Europe PubMed Central

The state of the prion (English)

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prion protein family

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author name string

Charles Weissmann

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publication date

November 2004

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Nature Reviews Microbiology

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2

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11

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861-71

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Mice devoid of PrP are resistant to scrapie

1 reference

https://api.crossref.org/works/10.1038/NRMICRO1025

21 April 2017

Strain-specified relative conformational stability of the scrapie prion protein

1 reference

https://api.crossref.org/works/10.1038/NRMICRO1025

21 April 2017

Impaired prion replication in spleens of mice lacking functional follicular dendritic cells

1 reference

https://api.crossref.org/works/10.1038/NRMICRO1025

21 April 2017

Conformational disease

1 reference

https://api.crossref.org/works/10.1038/NRMICRO1025

21 April 2017

A yeast prion provides a mechanism for genetic variation and phenotypic diversity

1 reference

https://api.crossref.org/works/10.1038/NRMICRO1025

21 April 2017

Eight prion strains have PrP(Sc) molecules with different conformations

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

21 April 2017

Novel proteinaceous infectious particles cause scrapie

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

A cellular gene encodes scrapie PrP 27-30 protein

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Prions causing degenerative neurological diseases

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Yeast prions act as genes composed of self-propagating protein amyloids

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Prion protein and the transmissible spongiform encephalopathy diseases

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Transmissible encephalopathies: speculations and realities

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Scrapie agent: prions or virinos?

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Self-replication and scrapie

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Molecular biology of prion diseases

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

A 'unified theory' of prion propagation

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Separation and properties of cellular and scrapie prion proteins

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

A protease-resistant protein is a structural component of the scrapie prion.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Differences in proteinase K resistance and neuronal deposition of abnormal prion proteins characterize bovine spongiform encephalopathy (BSE) and scrapie strains.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Rapid acquisition of beta-sheet structure in the prion protein prior to multimer formation

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Prion rods contain an inert polysaccharide scaffold

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Copurification of Sp33-37 and scrapie agent from hamster brain prior to detectable histopathology and clinical disease

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

The prion's progress

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Transmission of fatal familial insomnia to laboratory animals.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Evidence suggesting that PrP is not the infectious agent in Creutzfeldt-Jakob disease.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Mutant PrPSc conformers induced by a synthetic peptide and several prion strains

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Genetics of prions

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Influence of amino acid substitutions related to inherited human prion diseases on the thermodynamic stability of the cellular prion protein.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Prion replication and secondary nucleation

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Molecular basis of barriers for interspecies transmissibility of mammalian prions

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Prions of yeast as heritable amyloidoses

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variation in the PRNP gene.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

A new variant of prion disease

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Characterization of scrapie infection in mouse neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

In vitro replication of scrapie agent in a neuronal model: infection of PC12 cells.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Cultured cell sublines highly susceptible to prion infection

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Molecular analysis of bovine spongiform encephalopathy and scrapie strain variation

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Cell-free formation of protease-resistant prion protein.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

RNA molecules stimulate prion protein conversion

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Synthetic mammalian prions

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Improved conformation-dependent immunoassay: suitability for human prion detection with enhanced sensitivity

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Methods for studying prion protein (PrP) metabolism and the formation of protease-resistant PrP in cell culture and cell-free systems. An update

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Conformational variations in an infectious protein determine prion strain differences

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Protein-only transmission of three yeast prion strains

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Temporary and permanent modifications to a single strain of mouse scrapie on transmission to rats and hamsters

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Selective neuronal targeting in prion disease

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Environmental sources of prion transmission in mule deer

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Species-barrier-independent prion replication in apparently resistant species

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Long-term subclinical carrier state precedes scrapie replication and adaptation in a resistant species: analogies to bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease in humans

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Identification of multiple quantitative trait loci linked to prion disease incubation period in mice

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Quantitative trait loci affecting prion incubation time in mice

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

[URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Prions of yeast as epigenetic phenomena: high protein "copy number" inducing protein "silencing".

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Self-seeded fibers formed by Sup35, the protein determinant of [PSI+], a heritable prion-like factor of S. cerevisiae.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Migrating intestinal dendritic cells transport PrP(Sc) from the gut.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

PrP expression in B lymphocytes is not required for prion neuroinvasion

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Turning off follicular dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: role of prion protein expression in peripheral nerves and spleen

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Normal host prion protein necessary for scrapie-induced neurotoxicity.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability: a critical role for the putative transmembrane domain

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Transmissible and genetic prion diseases share a common pathway of neurodegeneration

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

A transmembrane form of the prion protein in neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Experimental transmission of Creutzfeldt-Jakob disease and related diseases to rodents

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Molecular distinction between pathogenic and infectious properties of the prion protein

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Transmissible familial Creutzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Inherited prion diseases and transmission to rodents

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Designing conditions for in vitro formation of amyloid protofilaments and fibrils

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Molecular biology of prion diseases

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

31 March 2020

Protease sensitivity and nuclease resistance of the scrapie agent propagated in vitro in neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

7 January 2021

based on heuristic

inferred from DOI database lookup

Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1025

7 January 2021

based on heuristic

inferred from DOI database lookup

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