(Q28289347)

Gene Ontology release 2020-05-02

David G Lambert

1

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language of work or name

English

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publication date

August 2008

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published in

Nature Reviews Drug Discovery

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volume

7

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issue

8

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page(s)

694-710

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cites work

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

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Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

31 March 2020

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Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications

31 March 2020

1 reference

Nociceptin/orphanin FQ and its receptor--potential targets for pain therapy?

31 March 2020

1 reference

31 March 2020

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Cellular actions of nociceptin: transduction mechanisms.

31 March 2020

1 reference

The ORL1 receptor: molecular pharmacology and signalling mechanisms

31 March 2020

1 reference

Modulation of voltage-gated calcium channels by orphanin FQ in freshly dissociated hippocampal neurons.

31 March 2020

1 reference

Increase by the ORL1 receptor (opioid receptor-like1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones.

31 March 2020

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Nociceptin induced inhibition of K+ evoked glutamate release from rat cerebrocortical slices

31 March 2020

1 reference

Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex

31 March 2020

1 reference

Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide

31 March 2020

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Differential activation of ERK, p38, and JNK MAPK by nociceptin/orphanin FQ in the potentiation of prostaglandin cerebrovasoconstriction after brain injury

31 March 2020

1 reference

Pertussis Toxin-Insensitive Signaling of the ORL1 Receptor: Coupling to Gz and G16 Proteins

31 March 2020

1 reference

Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.

31 March 2020

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A new selective antagonist of the nociceptin receptor.

31 March 2020

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N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands.

31 March 2020

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Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids.

31 March 2020

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Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist

31 March 2020

1 reference

[Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.

31 March 2020

1 reference

UFP-101, a peptide antagonist selective for the nociceptin/orphanin FQ receptor.

31 March 2020

1 reference

Pharmacological characterization of the novel nociceptin/orphanin FQ receptor ligand, ZP120: in vitro and in vivo studies in mice

31 March 2020

1 reference

Recognition and activation of the opioid receptor-like ORL 1 receptor by nociceptin, nociceptin analogs and opioids

31 March 2020

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Comparison of the effects of [Phe1psi(CH2-NH)Gly2]nociceptin(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors

31 March 2020

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[Nphe(1)]nociceptin-(1-13)-NH(2) antagonizes nociceptin effects in the mouse colon.

31 March 2020

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In vitro characterization of Ac-RYYRWK-NH(2), Ac-RYYRIK-NH(2) and [Phe1Psi(CH(2)-NH)Gly2] nociceptin(1-13)NH(2) at rat native and recombinant ORL(1) receptors

31 March 2020

1 reference

Partial agonist behaviour depends upon the level of nociceptin/orphanin FQ receptor expression: studies using the ecdysone-inducible mammalian expression system.

31 March 2020

1 reference

Ligands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library

31 March 2020

1 reference

Conformational preferences of [Leu5]enkephalin in biomimetic media. Investigation by 1H NMR.

31 March 2020

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Designing peptide receptor agonists and antagonists

31 March 2020

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Peptide and nonpeptide ligands for the nociceptin/orphanin FQ receptor ORL1: research tools and potential therapeutic agents

31 March 2020

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The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510).

31 March 2020

1 reference

Nonpeptidic ligands for peptide-activated G protein-coupled receptors.

31 March 2020

1 reference

Pharmacological properties of a novel nociceptin/orphanin FQ receptor agonist, 2-(3,5-dimethylpiperazin-1-yl)-1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1H-benzimidazole, with anxiolytic potential

31 March 2020

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Molecular modelling studies on the ORL1-receptor and ORL1-agonists

31 March 2020

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Molecular modelling of the ORL1 receptor and its complex with nociceptin

31 March 2020

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Small-molecule agonists and antagonists of the opioid receptor-like receptor (ORL1, NOP): ligand-based analysis of structural factors influencing intrinsic activity at NOP

31 March 2020

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Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla

31 March 2020

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A cellular mechanism for the bidirectional pain-modulating actions of orphanin FQ/nociceptin

31 March 2020

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Endogenous orphanin FQ: evidence for a role in the modulation of electroacupuncture analgesia and the development of tolerance to analgesia produced by morphine and electroacupuncture

31 March 2020

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Spinal analgesic activity of orphanin FQ/nociceptin and its fragments

31 March 2020

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Effects of intrathecally administered nociceptin/orphanin FQ in monkeys: behavioral and mass spectrometric studies.

31 March 2020

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Orphanin FQ is a functional anti-opioid peptide.

31 March 2020

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In vivo pain-inhibitory role of nociceptin/orphanin FQ in spinal cord

31 March 2020

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Depression of glutamatergic transmission by nociceptin in the neonatal rat hemisected spinal cord preparation in vitro

31 March 2020

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Antagonism of ORLI receptor produces an algesic effect in the rat formalin test.

31 March 2020

1 reference

In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist

31 March 2020

1 reference

Modification of Nociception and Morphine Tolerance by the Selective Opiate Receptor-Like Orphan Receptor Antagonist (–)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111)

31 March 2020

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Endogenous nociceptin/orphanin FQ signalling produces opposite spinal antinociceptive and supraspinal pronociceptive effects in the mouse formalin test: Pharmacological and genetic evidences

31 March 2020

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Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor

31 March 2020

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Intradermal nociceptin elicits itch-associated responses through leukotriene B(4) in mice.

31 March 2020

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The inhibitory effect of nociceptin on the micturition reflex in anaesthetized rats

31 March 2020

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Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells.

31 March 2020

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Attacking pain at its source: new perspectives on opioids

31 March 2020

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Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors

31 March 2020

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Spinal and local peripheral antiallodynic activity of Ro64-6198 in neuropathic pain in the rat

31 March 2020

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Peripheral orphanin FQ/nociceptin analgesia in the mouse

31 March 2020

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Opioid tolerance: the clinical perspective

31 March 2020

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Lack of cross-tolerance between the antinociceptive effect of intrathecal orphanin FQ and morphine in the rat

31 March 2020

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Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene

31 March 2020

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Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence.

31 March 2020

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The nociceptin/orphanin FQ receptor antagonist, [Nphe1]NC(1-13)NH2, potentiates morphine analgesia

31 March 2020

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Endogenous orphanin FQ/nociceptin is involved in the development of morphine tolerance

31 March 2020

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Editorial III: Nociceptin/orphanin FQ peptide-receptor system: are we any nearer the clinic?

31 March 2020

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Quantitative analysis of nociceptin in blood of patients with acute and chronic pain

31 March 2020

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Plasma levels on nociceptin in female fibromyalgia syndrome patients

31 March 2020

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Circulating nociceptin levels during the cluster headache period.

31 March 2020

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Identification of nociceptin in human cerebrospinal fluid: comparison of levels in pain and non-pain states

31 March 2020

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Does nociceptin play a role in pain disorders in man?

31 March 2020

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From monoamines to genomic targets: a paradigm shift for drug discovery in depression

31 March 2020

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Recent developments in anxiety disorders.

31 March 2020

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Antidepressant- and anxiolytic-like effects of nociceptin/orphanin FQ receptor ligands.

31 March 2020

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Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress

31 March 2020

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Central injections of nocistatin or its C-terminal hexapeptide exert anxiogenic-like effect on behaviour of mice in the plus-maze test

31 March 2020

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Nociceptin receptor antagonists display antidepressant-like properties in the mouse forced swimming test

31 March 2020

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Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test.

31 March 2020

1 reference

Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice

31 March 2020

1 reference

8-acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as orphanin FQ receptor agonists

31 March 2020

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A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.

31 March 2020

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Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

31 March 2020

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Nociceptin/orphanin FQ increases anxiety-related behavior and circulating levels of corticosterone during neophobic tests of anxiety.

31 March 2020

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Impact of environmental housing conditions on the emotional responses of mice deficient for nociceptin/orphanin FQ peptide precursor gene

31 March 2020

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Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice

31 March 2020

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Opioid receptor-like 1 (NOP) receptors in the rat dorsal raphe nucleus: evidence for localization on serotoninergic neurons and functional adaptation after 5,7-dihydroxytryptamine lesion.

31 March 2020

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GABA(A) signalling is involved in N/OFQ anxiolytic-like effects but not in nocistatin anxiogenic-like action as evaluated in the mouse elevated plus maze

31 March 2020

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Major Depressive Disorder

31 March 2020

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Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro

31 March 2020

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The pharmacology of Ro 64-6198, a systemically active, nonpeptide NOP receptor (opiate receptor-like 1, ORL-1) agonist with diverse preclinical therapeutic activity

31 March 2020

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Combating opiate dependence: a comparison among the available pharmacological options

31 March 2020

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Drugs for relapse prevention of alcoholism: ten years of progress

31 March 2020

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Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification

31 March 2020

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The treatment of alcohol dependence

31 March 2020

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Effect of nociceptin on alcohol intake in alcohol-preferring rats

31 March 2020

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Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats

31 March 2020

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Acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in mice: effects of opioid receptor-like 1 receptor agonists and naloxone

31 March 2020

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Nociceptin inhibits acquisition of amphetamine-induced place preference and sensitization to stereotypy in rats.

31 March 2020

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Orphanin FQ/nociceptin but not Ro 65-6570 inhibits the expression of cocaine-induced conditioned place preference

31 March 2020

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Central administration of nociceptin/orphanin FQ blocks the acquisition of conditioned place preference to morphine and cocaine, but not conditioned place aversion to naloxone in mice

31 March 2020

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Endogenous nociceptin (orphanin FQ) suppresses basal hedonic state and acute reward responses to methamphetamine and ethanol, but facilitates chronic responses

31 March 2020

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Intracerebroventricular orphanin FQ/nociceptin suppresses dopamine release in the nucleus accumbens of anaesthetized rats.

31 March 2020

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Orphanin FQ/nociceptin modulation of mesolimbic dopamine transmission determined by microdialysis

31 March 2020

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Nociceptin differentially affects morphine-induced dopamine release from the nucleus accumbens and nucleus caudate in rats

31 March 2020

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Orphanin FQ reduces morphine-induced dopamine release in the nucleus accumbens: a microdialysis study in rats

31 March 2020

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Orphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats

31 March 2020

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Control of glutamate and GABA release by nociceptin/orphanin FQ in the rat lateral amygdala

31 March 2020

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Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in central amygdala

31 March 2020

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Effects of nociceptinNH2 and [Nphe1]nociceptin(1-13)NH2 on rat brain noradrenaline release in vivo and in vitro.

31 March 2020

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Nociceptin/orphanin FQ and drugs of abuse

31 March 2020

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The nociceptin/orphanin FQ/NOP receptor system as a target for treatment of alcohol abuse: a review of recent work in alcohol-preferring rats

31 March 2020

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Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats

31 March 2020

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The nociceptin/orphanin FQ receptor agonist Ro 64-6198 reduces alcohol self-administration and prevents relapse-like alcohol drinking

31 March 2020

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Effect of novel nociceptin/orphanin FQ-NOP receptor ligands on ethanol drinking in alcohol-preferring msP rats

31 March 2020

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Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system

31 March 2020

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Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat.

31 March 2020

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Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence

31 March 2020

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Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence

31 March 2020

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Neurohumoral effects of orphanin FQ/nociceptin: relevance to cardiovascular and renal function

31 March 2020

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Characterization of nociceptin receptors in the periphery: in vitro and in vivo studies

31 March 2020

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Effect of nociceptin on heart rate and blood pressure in anaesthetized rats.

31 March 2020

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Inhibition of cardiovascular activity following microinjection of novel opioid-like neuropeptide nociceptin (orphanin FQ) into the rat rostral ventrolateral medulla

31 March 2020

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Functional Selectivity of Nociceptin/Orphanin FQ Peptide Receptor Partial Agonists on Cardiovascular and Renal Function

31 March 2020

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Nitric oxide release mediates vasodilator responses to endomorphin 1 but not nociceptin/OFQ in the hindquarters vascular bed of the rat.

31 March 2020

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Nociceptin, a novel endogenous ligand for the ORL1 receptor, dilates isolated resistance arteries from the rat.

31 March 2020

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Role of nitric oxide in mediating vasodilator responses to opioid peptides in the rat.

31 March 2020

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Role of Nociceptin/Orphanin FQ in the physiologic and pathologic control of the cerebral circulation.

31 March 2020

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Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine.

31 March 2020

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Stimulating effect of nociceptin on histamine release in the rat brain?

31 March 2020

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Intradermal application of nociceptin increases vascular permeability in rats: the possible involvement of histamine release from mast cells

31 March 2020

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31 March 2020

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Nociceptin and urotensin-II concentrations in critically ill patients with sepsis

31 March 2020

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Characterization of the high affinity [3H]nociceptin binding site in membrane preparations of rat heart: correlations with the non-opioid dynorphin binding site

31 March 2020

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Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ.

31 March 2020

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Nociceptin/orphanin FQ increases ANP secretion in neonatal cardiac myocytes

31 March 2020

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Nociceptin/orphanin FQ increases blood pressure and heart rate via sympathetic activation in sheep

31 March 2020

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Differential down-regulation of aquaporin-2 in rat kidney zones by peripheral nociceptin/orphanin FQ receptor agonism and vasopressin type-2 receptor antagonism

31 March 2020

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ZP120 causes relaxation by pre-junctional inhibition of noradrenergic neurotransmission in rat mesenteric resistance arteries

31 March 2020

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The challenge of overactive bladder therapy: alternative to antimuscarinic agents

31 March 2020

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The mouse vas deferens: a pharmacological preparation sensitive to nociceptin

31 March 2020

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Determination of activity for nociceptin in the mouse vas deferens

31 March 2020

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Nociceptin protects capsaicin-sensitive afferent fibers in the rat urinary bladder from desensitization

31 March 2020

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Tachykinin-mediated effect of nociceptin in the rat urinary bladder in vivo.

31 March 2020

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Nociceptin and the micturition reflex.

31 March 2020

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Urodynamic and clinical evidence of acute inhibitory effects of intravesical nociceptin/orphanin FQ on detrusor overactivity in humans: a pilot study

31 March 2020

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Urodynamic effects of intravesical nociceptin/orphanin FQ in neurogenic detrusor overactivity: a randomized, placebo-controlled, double-blind study

31 March 2020

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Daily Intravesical Instillation of 1 mg Nociceptin/Orphanin FQ for the Control of Neurogenic Detrusor Overactivity: A Multicenter, Placebo Controlled, Randomized Exploratory Study

31 March 2020

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The neural control of micturition

31 March 2020

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Mechanisms underlying the recovery of urinary bladder function following spinal cord injury

31 March 2020

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Is immunomodulation by opioid drugs of clinical relevance?

31 March 2020

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Pain management: is opioid immunosuppression a clinical problem?

31 March 2020

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Infections resulting from narcotic addiction; report of 102 cases.

31 March 2020

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Opioid-induced immunosuppression: is it centrally mediated or peripherally mediated?

31 March 2020

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Human peripheral blood mononuclear cells express nociceptin/orphanin FQ, but not mu, delta, or kappa opioid receptors.

31 March 2020

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Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site

31 March 2020

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Nociceptin/orphanin FQ stimulates human monocyte chemotaxis via NOP receptor activation

31 March 2020

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Human neutrophils as a source of nociceptin: a novel link between pain and inflammation.

31 March 2020

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Nociceptin/orphanin FQ modulates human T cell function in vitro.

31 March 2020

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Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons

31 March 2020

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Orphanin FQ/nociceptin interactions with the immune system in vivo: gene expression changes in lymphoid organs and regulation of the cytokine response to staphylococcal enterotoxin A

31 March 2020

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Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis

31 March 2020

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Antitussive effect of nociceptin/orphanin FQ in experimental cough models

31 March 2020

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Effect of nociceptin in acid-evoked cough and airway sensory nerve activation in guinea pigs

31 March 2020

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Antitussive action of nociceptin in the cat.

31 March 2020

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Nociceptin inhibits vanilloid TRPV-1-mediated neurosensitization induced by fenoterol in human isolated bronchi.

31 March 2020

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Antitussive profile of the NOP agonist Ro-64-6198 in the guinea pig.

31 March 2020

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Orphanin FQ/nociceptin: a novel neuromodulator of gastrointestinal function?

31 March 2020

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Nociceptin/orphanin FQ prevents ethanol-induced gastric lesions in the rat.

31 March 2020

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Nociceptin/orphanin FQ prevents gastric damage induced by cold-restraint stress in the rat by acting in the periphery

31 March 2020

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Gastrointestinal effects of intracerebroventricularly injected nociceptin/orphaninFQ in rats

31 March 2020

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Gastric acid secretion stimulated by centrally injected nociceptin in urethane-anesthetized rats

31 March 2020

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Effects of Ro 64-6198 in nociceptin/orphanin FQ-sensitive isolated tissues

31 March 2020

1 reference

Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies.

31 March 2020

1 reference

Antidepressant agents for the treatment of chronic pain and depression

31 March 2020

1 reference

Oral methylnaltrexone for opioid-induced constipation

31 March 2020

1 reference

Intrathecal opioids for combined spinal-epidural analgesia during labour

31 March 2020

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Remifentanil and other opioids

31 March 2020

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Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice

31 March 2020

1 reference

Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties

31 March 2020

1 reference

Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).

31 March 2020

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Activities of mixed NOP and mu-opioid receptor ligands.

31 March 2020

1 reference

SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a novel mixed nociceptin/orphanin FQ/mu-opioid receptor partial agonist: analgesic and rewarding properties in mice

31 March 2020

1 reference

Opiate Receptor: Demonstration in Nervous Tissue

31 March 2020

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Opiate agonists and antagonists discriminated by receptor binding in brain.

31 March 2020

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Comparison of the structure-activity relationships of nociceptin and dynorphin A using chimeric peptides

31 March 2020

1 reference

Structure-activity relationship studies on the novel neuropeptide orphanin FQ.

31 March 2020

1 reference

Orphanin FQ: receptor binding and analog structure activity relationships in rat brain

31 March 2020

1 reference

Pharmacology of [Tyr1]nociceptin analogs: receptor binding and bioassay studies

31 March 2020

1 reference

Distinct mechanisms for activation of the opioid receptor-like 1 and kappa-opioid receptors by nociceptin and dynorphin A.

31 March 2020

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Structures that delineate orphanin FQ and dynorphin A pharmacological selectivities

31 March 2020

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Further Studies on Nociceptin-Related Peptides: Discovery of a New Chemical Template with Antagonist Activity on the Nociceptin Receptor

31 March 2020

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Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor

31 March 2020

1 reference

[(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), a highly potent and selective agonist of the nociceptin/orphanin FQ receptor.

31 March 2020

1 reference

Pharmacological profile of the cyclic nociceptin/orphanin FQ analogues c[Cys10,14]N/OFQ(1-14)NH2 and c[Nphe1,Cys10,14]N/OFQ(1-14)NH2.

31 March 2020

1 reference

In vitro pharmacological characterisation of a novel cyclic nociceptin/orphanin FQ analogue c[Cys(7,10)]N/OFQ(1-13)NH (2).

31 March 2020

1 reference

Acetyl-RYYRIK-NH(2) is a highly efficacious OP(4) receptor agonist in the cardiovascular system of anesthetized rats.

31 March 2020

1 reference

Pharmacodynamic characterization of ZP120 (Ac-RYYRWKKKKKKK-NH2), a novel, functionally selective nociceptin/orphanin FQ peptide receptor partial agonist with sodium-potassium-sparing aquaretic activity

31 March 2020

1 reference

Structure-activity studies on high affinity NOP-active hexapeptides

31 March 2020

1 reference

Anti-nociceptive and anti-allodynic effects of a high affinity NOP hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in rodents

31 March 2020

1 reference

Effect of novel NOP receptor ligands on food intake in rats.

31 March 2020

1 reference

Pharmacological properties of TRK-820 on cloned mu-, delta- and kappa-opioid receptors and nociceptin receptor.

31 March 2020

1 reference

Blockade of mu-opioid receptor-mediated G-protein activation and antinociception by TRK-820 in mice

31 March 2020

1 reference

TRK-820, a selective kappa-opioid agonist, produces potent antinociception in cynomolgus monkeys

31 March 2020

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Inhibitory effects of TRK-820 on systemic skin scratching induced by morphine in rhesus monkeys

31 March 2020

1 reference

Agonistic effects of the opioid buprenorphine on the nociceptin/OFQ receptor

31 March 2020

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Buprenorphine activates mu and opioid receptor like-1 receptors simultaneously, but the analgesic effect is mainly mediated by mu receptor activation in the rat formalin test

31 March 2020

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Loss of antinociception induced by naloxone benzoylhydrazone in nociceptin receptor-knockout mice.

31 March 2020

1 reference

The in vitro pharmacological characterization of naloxone benzoylhydrazone

31 March 2020

1 reference

Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801

31 March 2020

1 reference

Characterization of nociceptin/orphanin FQ-induced pain responses by the novel receptor antagonist N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl) benzamide monohydrochloride

31 March 2020

1 reference

In vitro characterization of J-113397, a non-peptide nociceptin/orphanin FQ receptor antagonist

31 March 2020

1 reference

Characterisation and comparison of novel ligands for the nociceptin/orphanin FQ receptor

31 March 2020

1 reference

Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist.

31 March 2020

1 reference

Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vivo studies.

31 March 2020

1 reference

Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.

31 March 2020

1 reference

Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.

31 March 2020

1 reference

(8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4. 5]dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist

31 March 2020

1 reference