(Q35709598)

9 August 2017

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title

From monoamines to genomic targets: a paradigm shift for drug discovery in depression (English)

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9 August 2017

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1

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9 August 2017

Julio Licinio

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publication date

1 February 2004

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Nature Reviews Drug Discovery

9 August 2017

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9 August 2017

3

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9 August 2017

136-151

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9 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrd1303

9 August 2017

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31 March 2020

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31 March 2020

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Prospects for improved antidepressants

31 March 2020

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SNaRIs, NaSSAs, and NaRIs: new agents for the treatment of depression

31 March 2020

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SSRIs versus tricyclic antidepressants in depressed inpatients: A meta-analysis of efficacy and tolerability

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Remission rates during treatment with venlafaxine or selective serotonin reuptake inhibitors

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New approaches to developing antidepressants by enhancing monoaminergic neurotransmission

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A Syndrome produced by Diverse Nocuous Agents

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The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis

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Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications

31 March 2020

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The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications

31 March 2020

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Chronic imipramine is associated with diminished hypothalamic-pituitary-adrenal axis responsivity in healthy humans.

31 March 2020

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Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

31 March 2020

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Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone

31 March 2020

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Psychiatric implications of basic and clinical studies with corticotropin-releasing factor

31 March 2020

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Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing's disease. Pathophysiologic and diagnostic implications

31 March 2020

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Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls

31 March 2020

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Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients

31 March 2020

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Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates

31 March 2020

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Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

31 March 2020

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A hypothesis of thyroid-catecholamine-receptor interaction. Its relevance to affective illness

31 March 2020

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The endocrinology of melancholic and atypical depression: relation to neurocircuitry and somatic consequences

31 March 2020

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Differential response of substance P-containing subtypes of adrenomedullary cells to different stressors

31 March 2020

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Stimulation of ACTH/Cortisol by Intravenously Infused Substance P in Normal Men: Inhibition by Sodium Valproate

31 March 2020

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Distinct mechanism for antidepressant activity by blockade of central substance P receptors

31 March 2020

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Substance P antagonists: novel agents in the treatment of depression

31 March 2020

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Prevention of cisplatin-induced emesis by the oral neurokinin-1 antagonist, MK-869, in combination with granisetron and dexamethasone or with dexamethasone alone

31 March 2020

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Treatment of mood disorders

31 March 2020

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Stress and hippocampal plasticity

31 March 2020

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Clinical trial for Parkinson's disease?

31 March 2020

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Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson's disease: a randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial

31 March 2020

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Selegiline treatment facilitates recovery after stroke

31 March 2020

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Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume.

31 March 2020

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Neuronal plasticity and survival in mood disorders.

31 March 2020

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Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus.

31 March 2020

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Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments.

31 March 2020

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Antidepressant-like effect of brain-derived neurotrophic factor (BDNF).

31 March 2020

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Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus

31 March 2020

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Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment

31 March 2020

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Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

31 March 2020

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The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection

31 March 2020

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Depression, stress and immunological activation: the role of cytokines in depressive disorders

31 March 2020

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Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1.

31 March 2020

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Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor

31 March 2020

1 reference

The relationship of depression and stressors to immunological assays: a meta-analytic review

31 March 2020

1 reference

Higher alpha 1-antitrypsin, haptoglobin, ceruloplasmin and lower retinol binding protein plasma levels during depression: further evidence for the existence of an inflammatory response during that illness

31 March 2020

1 reference

Changes in immunoglobulin, complement and acute phase protein levels in the depressed patients and normal controls

31 March 2020

1 reference

Forced swim test-induced endocrine and immune changes in the rat: effect of subacute desipramine treatment

31 March 2020

1 reference

Effects of antidepressants on cytokine production and actions.

31 March 2020

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The immune system, depression and the action of antidepressants

31 March 2020

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Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders

31 March 2020

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Borna disease virus genome transcribed and expressed in psychiatric patients

31 March 2020

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Transcription factors responsive to cAMP

31 March 2020

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Protein phosphorylation in neuronal plasticity and gene expression

31 March 2020

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Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein.

31 March 2020

1 reference

Noradrenergic antidepressants: does chronic treatment increase or decrease nuclear CREB-P?

31 March 2020

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Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus.

31 March 2020

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Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect.

31 March 2020

1 reference

CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals

31 March 2020

1 reference

Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression.

31 March 2020

1 reference

Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum

31 March 2020

1 reference

Regulation of cocaine reward by CREB.

31 March 2020

1 reference

Differentiation of two genetically specific types of depression by the response to anti-depressants

31 March 2020

1 reference

The pharmacogenomics of depression

31 March 2020

1 reference

Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine

31 March 2020

1 reference

Identification of hypothalamic transcripts upregulated by antidepressants.

31 March 2020

1 reference

Molecular characterisation of antidepressant effects in the mouse brain using gene expression profiling

31 March 2020

1 reference

Differential expression of VAMP2/synaptobrevin-2 after antidepressant and electroconvulsive treatment in rat frontal cortex.

31 March 2020

1 reference

Sustained Increase in Narp Protein Expression Following Repeated Electroconvulsive Seizure

31 March 2020

1 reference

Chronic amitriptyline treatment induces hippocampal NGFI-A, glucocorticoid receptor and mineralocorticoid receptor mRNA expression in rats.

31 March 2020

1 reference

Fluoxetine induces the transcription of genes encoding c-fos, corticotropin-releasing factor and its type 1 receptor in rat brain

31 March 2020

1 reference

Selective effects on NGFI-A, MR, GR and NGFI-B hippocampal mRNA expression after chronic treatment with different subclasses of antidepressants in the rat

31 March 2020

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cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment.

31 March 2020

1 reference

St John's wort and imipramine-induced gene expression profiles identify cellular functions relevant to antidepressant action and novel pharmacogenetic candidates for the phenotype of antidepressant treatment response

31 March 2020

1 reference

Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro

31 March 2020

1 reference

Environment and vulnerability to major psychiatric illness: a case control study of early parental loss in major depression, bipolar disorder and schizophrenia

31 March 2020

1 reference

Learned helplessness in the rat: improvements in validity and reliability.

31 March 2020

1 reference

“Behavioural despair” in rats and mice: Strain differences and the effects of imipramine

31 March 2020

1 reference

Neurobehavioral studies of forced swimming: the role of learning and memory in the forced swim test

31 March 2020

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Intra- and interstrain differences in models of "behavioral despair".

31 March 2020

1 reference

Limitations on the use of the C57BL/6 mouse in the tail suspension test

31 March 2020

1 reference

Toward a cellular analysis of intracranial self-stimulation: contributions of collision studies

31 March 2020

1 reference

Sucrose consumption as an hedonic measure following chronic unpredictable mild stress.

31 March 2020

1 reference

Chronic mild stress and sucrose consumption: validity as a model of depression.

31 March 2020

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Failure to change exploration or saccharin preference in rats exposed to chronic mild stress.

31 March 2020

1 reference

The olfactory bulbectomized rat as a model of depression: an update

31 March 2020

1 reference

Characteristics of changes in cholinergic function and impairment of learning and memory-related behavior induced by olfactory bulbectomy

31 March 2020

1 reference

Acute and chronic stress effects on open field activity in the rat: implications for a model of depression

31 March 2020

1 reference

Chronic mild stress-induced anhedonia: a realistic animal model of depression

31 March 2020

1 reference

Amphetamine withdrawal: a behavioral evaluation

31 March 2020

1 reference

Withdrawal from chronic morphine administration causes prolonged enhancement of immobility in rat forced swimming test

31 March 2020

1 reference

Withdrawal from chronic amphetamine induces depressive-like behavioral effects in rodents

31 March 2020

1 reference

Early experience as a determinant of adult behavioural responses to reward: the effects of repeated maternal separation in the rat

31 March 2020

1 reference

Long-term neurobehavioural impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms

31 March 2020

1 reference

A new animal model of endogenous depression: a summary of present findings

31 March 2020

1 reference

The Flinders sensitive line rats: a genetic animal model of depression

31 March 2020

1 reference

Behavioral characteristics of rat lines selected for differential hypothermic responses to cholinergic or serotonergic agonists

31 March 2020

1 reference

The Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholism

31 March 2020

1 reference

Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression

31 March 2020

1 reference

A genetic mouse model of helplessness sensitive to imipramine

31 March 2020

1 reference

Serotonin receptor 1A knockout: an animal model of anxiety-related disorder

31 March 2020

1 reference

Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice

31 March 2020

1 reference

Increased anxiety of mice lacking the serotonin1A receptor

31 March 2020

1 reference

Involvement of 5-HT1A receptors in homeostatic and stress-induced adaptive regulations of paradoxical sleep: studies in 5-HT1A knock-out mice.

31 March 2020

1 reference

The effects of selective serotonin reuptake inhibitors on extracellular 5-HT levels in the hippocampus of 5-HT(1B) receptor knockout mice

31 March 2020

1 reference

Improved efficacy of fluoxetine in increasing hippocampal 5-hydroxytryptamine outflow in 5-HT(1B) receptor knock-out mice

31 March 2020

1 reference

Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter

31 March 2020

1 reference

Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity.

31 March 2020

1 reference

The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety

31 March 2020

1 reference

Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels.

31 March 2020

1 reference

Behavioral responses to social stress in noradrenaline transporter knockout mice: effects on social behavior and depression.

31 March 2020

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Altered regulation of the 5-HT system in the brain of MAO-A knock-out mice

31 March 2020

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Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA

31 March 2020

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Increased stress response and beta-phenylethylamine in MAOB-deficient mice

31 March 2020

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Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses

31 March 2020

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Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65.

31 March 2020

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Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).

31 March 2020

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Lower sensitivity to stress and altered monoaminergic neuronal function in mice lacking the NMDA receptor epsilon 4 subunit.

31 March 2020

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Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7

31 March 2020

1 reference

Comparison of the phenotype of NK1R-/- mice with pharmacological blockade of the substance P (NK1 ) receptor in assays for antidepressant and anxiolytic drugs

31 March 2020

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5-hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization.

31 March 2020

1 reference

Diminished anxiety- and depression-related behaviors in mice with selective deletion of the Tac1 gene.

31 March 2020

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Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function.

31 March 2020

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HPA axis dysregulation in mice overexpressing corticotropin releasing hormone

31 March 2020

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Effects of transgenic overproduction of CRH on anxiety-like behaviour

31 March 2020

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Increased depression-like behaviors in corticotropin-releasing factor receptor-2-deficient mice: sexually dichotomous responses.

31 March 2020

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Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice

31 March 2020

1 reference

Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-alpha gene: implications for emotional behavior.

31 March 2020

1 reference

Interleukin-6 involvement in antidepressant action of Hypericum perforatum

31 March 2020

1 reference

Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac).

31 March 2020

1 reference

Reduced anxiety-- and depression-like behaviors in Emx1 homozygous mutant mice

31 March 2020

1 reference

Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects.

31 March 2020

1 reference

RGS9 modulates dopamine signaling in the basal ganglia

31 March 2020

1 reference

Adenosine A2A receptor knockout mice are partially protected against drug-induced catalepsy

31 March 2020

1 reference

Neuronal nicotinic receptors: insights gained from gene knockout and knockin mutant mice

31 March 2020

1 reference

Involvement of CB1 cannabinoid receptors in emotional behaviour.

31 March 2020

1 reference

Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test.

31 March 2020

1 reference

Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors

31 March 2020

1 reference

Behavioral characterization of dopamine D5 receptor null mutant mice

31 March 2020

1 reference

Reduction of depressive-like behavior in mice lacking angiotensinogen.

31 March 2020

1 reference

Recovery of emotional behaviour in neural cell adhesion molecule (NCAM) null mutant mice through transgenic expression of NCAM180.

31 March 2020

1 reference

Changes in sleep architecture following chronic mild stress.

31 March 2020

1 reference

Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice

31 March 2020

1 reference

Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity.

31 March 2020

1 reference

Stress-induced social avoidance: a new model of stress-induced anxiety?

31 March 2020

1 reference

Repeated injections of interferon-alpha A/D in Balb/c mice: behavioral effects.

31 March 2020

1 reference

Behavioral and cardiovascular changes in the chronic mild stress model of depression

31 March 2020

1 reference

Reduced attention in mice overproducing corticotropin-releasing hormone

31 March 2020

1 reference

Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1.

31 March 2020

1 reference

Cholinergic blockade impairs performance in operant DNMTP in two inbred strains of mice

31 March 2020

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Prenatal stress and long-term consequences: implications of glucocorticoid hormones

31 March 2020

1 reference

Potentiation of the time-dependent, antidepressant-induced changes in the agonistic behaviour of resident rats by the 5-HT1A receptor antagonist, WAY-100635

31 March 2020

1 reference

The reductions in sweetened milk intake induced by interleukin-1 and endotoxin are not prevented by chronic antidepressant treatment

31 March 2020

1 reference

Serotonin transporter gene polymorphism and antidepressant response

31 March 2020

1 reference

Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression

31 March 2020

1 reference

Efficacy of Paroxetine in Depression Is Influenced by a Functional Polymorphism Within the Promoter of the Serotonin Transporter Gene

31 March 2020

1 reference

Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatment

31 March 2020

1 reference

The role of serotonin transporter protein gene in antidepressant-induced mania in bipolar disorder: preliminary findings

31 March 2020

1 reference

Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity.

31 March 2020

1 reference

Factors affecting fluvoxamine antidepressant activity: influence of pindolol and 5-HTTLPR in delusional and nondelusional depression

31 March 2020

1 reference

Possible influence of the insertion/deletion polymorphism in the angiotensin I-converting enzyme gene on therapeutic outcome in affective disorders

31 March 2020

1 reference

Tyrosine hydroxylase gene associated with depressive symptomatology in mood disorder

31 March 2020

1 reference

No association between dopamine D(2) and D(4) receptor gene variants and antidepressant activity of two selective serotonin reuptake inhibitors

31 March 2020

1 reference

Influence of monoamine oxidase A and serotonin receptor 2A polymorphisms in SSRI antidepressant activity

31 March 2020

1 reference

A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression

31 March 2020

1 reference

Pharmacogenetics of antidepressant medication intolerance

31 March 2020

1 reference

Pharmacogenetics of antidepressant and mood-stabilizing drugs: a review of candidate-gene studies and future research directions

31 March 2020

1 reference

Research and treatment approaches to depression

31 March 2020

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The validity of animal models of predisposition to depression

31 March 2020

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Response and remission rates in different subpopulations with major depressive disorder administered venlafaxine, selective serotonin reuptake inhibitors, or placebo

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRD1303

1 reference

9 August 2017

1 reference

PubMed ID

15040578