(Q44085189)

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Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity.

scientific article published in August 2002

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Europe PubMed Central

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11 November 2019

Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity (English)

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11 November 2019

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Theresa M Ballard

1

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11 November 2019

Meike Pauly-Evers

2

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11 November 2019

Guy A Higgins

3

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11 November 2019

Abdel-Mouttalib Ouagazzal

4

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11 November 2019

Vincent Mutel

5

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11 November 2019

Edilio Borroni

6

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11 November 2019

John A Kemp

7

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11 November 2019

Horst Bluethmann

8

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11 November 2019

James N C Kew

9

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11 November 2019

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1 August 2002

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11 November 2019

Journal of Neuroscience

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11 November 2019

22

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11 November 2019

15

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11 November 2019

6713-6723

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11 November 2019

The 5-HT2A receptor antagonist M100907 is more effective in counteracting NMDA antagonist- than dopamine agonist-induced hyperactivity in mice

1 reference

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Mice with reduced NMDA receptor expression display behaviors related to schizophrenia

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NMDA receptor hypofunction model of schizophrenia

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Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site

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Mechanism of action of the hypnotic zolpidem in vivo

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Catching up on schizophrenia: natural history and neurobiology

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Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit

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Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence

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Influence of the selective ORL1 receptor agonist, Ro64-6198, on rodent neurological function.

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Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

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12 December 2020

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Drug-induced potentiation of prepulse inhibition of acoustic startle reflex in mice: a model for detecting antipsychotic activity?

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Heteromeric NMDA receptors: molecular and functional distinction of subtypes

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Molecular diversity of the NMDA receptor channel

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Recent advances in the phencyclidine model of schizophrenia

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12 December 2020

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Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-d-aspartate receptor

1 reference

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12 December 2020

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Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine

1 reference

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12 December 2020

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Glycine potentiates the NMDA response in cultured mouse brain neurons

1 reference

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12 December 2020

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Comparison of the behavioral and biochemical effects of the NMDA receptor antagonists, MK-801 and phencyclidine

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12 December 2020

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Neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A.

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12 December 2020

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Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes

1 reference

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12 December 2020

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Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1 reference

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12 December 2020

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Role of N-methyl-D-aspartate receptors in the induction of synaptic potentiation by burst stimulation patterned after the hippocampal theta-rhythm

1 reference

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12 December 2020

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Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells

1 reference

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12 December 2020

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Antipsychotic agents antagonize non-competitive N-methyl-D-aspartate antagonist-induced behaviors

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12 December 2020

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Blockade of phencyclidine-induced hyperlocomotion by clozapine and MDL 100,907 in rats reflects antagonism of 5-HT2A receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151550

12 December 2020

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inferred from PubMed ID database lookup

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151550

12 December 2020

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inferred from PubMed ID database lookup

The anticonvulsant and behavioural profile of L-687,414, a partial agonist acting at the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151550

12 December 2020

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Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151550

12 December 2020

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The pharmacology of SDZ EAA 494, a competitive NMDA antagonist

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12 December 2020

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Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins

1 reference

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12 December 2020

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Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death

1 reference

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Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice

1 reference

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12 December 2020

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Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile

1 reference

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12 December 2020

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The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.

1 reference

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Reversal of dizocilpine-induced disruption of prepulse inhibition of an acoustic startle response by the 5-HT2 receptor antagonist ketanserin

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Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice

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Pharmacological profile of benzodiazepine site ligands with recombinant GABAA receptor subtypes

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Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex

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The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

1 reference

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Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit

1 reference

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12 December 2020

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Control of NMDA receptor activation by a glycine transporter co-expressed in Xenopus oocytes

1 reference

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12 December 2020

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Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors

1 reference

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Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons.

1 reference

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Evidence for a tetrameric structure of recombinant NMDA receptors.

1 reference

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Identifiers

10.1523/JNEUROSCI.22-15-06713.2002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12151550%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12151550%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12151550%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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