(Q28289878)

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Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis

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Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis (English)

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J Hefner

1

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S M Rubenstein

2

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R E Ketchum

3

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D M Gibson

4

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R M Williams

5

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R Croteau

6

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publication date

June 1996

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Chemistry and Biology

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3

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6

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479-89

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Total synthesis of taxol

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Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew

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Purification and characterization of taxa-4(5),11(12)-diene synthase from Pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis

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10.1016/S1074-5521(96)90096-4

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