(Q40317968)

19 September 2017

1 reference

title

Inhibitors of Cytochrome P-450s and their mechanism of action (English)

1 reference

19 September 2017

Testa B

1

1 reference

PubMed ID

7028434

19 September 2017

Jenner P

series ordinal

2

1 reference

PubMed ID

7028434

19 September 2017

language of work or name

English

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publication date

1 January 1981

1 reference

19 September 2017

Drug Metabolism Reviews

1 reference

19 September 2017

12

1 reference

19 September 2017

1-117

1 reference

19 September 2017

1

1 reference

The effects of 1-alkylimidazoles on hepatic drug-metabolizing enzyme activity

19 September 2017

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Nature of O2 and CO binding to metalloporphyrins and heme proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Reduced nicotinamide adenine dinucleotide-dependent reduction of tertiary amine N-oxide by liver microsomal cytochrome P-450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Spin-labelled isocyanides as stereochemical probes for the active center of cytochromeP-450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Heterogeneity of liver microsomal cytochrome P-450: The spectral characterization of reactants with reduced cytochrome P-450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Trapping of metabolically generated electrophilic species with cyanide ion: metabolism of 1-benzylpyrrolidine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Nitrite binding to rabbit liver microsomes and effects on aminopyrine demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Effect of nitrite on microsomal cytochrome P-450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Spectral evidence for weak ligand in sixth position of hepatic microsomal cytochrome P-450 low spin ferric iron in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Models for ferric cytochrome P450. Characterization of hemin mercaptide complexes by electronic and ESR spectra

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Ethanol inhibition of vinyl chloride metabolism in isolated rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

A molecular orbital study on the interaction between the cytochrome P-450 and its substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Circular dichroism studies on the binding of Type I substrates and reverse Type I compounds to rabbit liver microsomal cytochrome P-450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Multiple forms of cytochrome P450 in the microsomal monooxygenase system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Comparative kinetics and inhibition of swine and sheep liver microsomal enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Inhibition of the mono-oxygenase system by butylated hydroxyanisole and butylated hydroxytoluene.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Influence of pyridine and some pyridine derivatives on spectral properties of reduced microsomes and on microsomal drug metabolizing activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

New inhibitors of steroid 11beta-hydroxylase. Structure--activity relationship studies of metyrapone-like compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Imidazole derivatives—A new class of microsomal enzyme inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Effects of Insecticide Synergists on Microsomal Oxidation of Estradiol and Ethynylestradiol and on Microsomal Drug Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Influence of steric factors on the interaction of isomeric phenyloxazoles and phenylthiazoles with microsomal oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

A class of strong inhibitors of microsomal monooxygenases: The elupticines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Species differences in the substrate specificity of hepatic cytochrome P-448 from polycyclic hydrocarbon-treated animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Inhibition of hepatic aryl hydrocarbon hydroxylase by 3-methylcholanthrene, 7,8-benzoflavone and other inducers added in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

A preliminary structure-activity study of the mixed-function oxidase inhibitor, 7,8-benzoflavone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Structure-activity relations for methylenedioxyphenyl and related compounds on hepatic microsomal enzyme function, as measured by prolongation of hexobarbital narcosis and zoxazolamine paralysis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

A novel haemoprotein induced by isosafrole pretreatment in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Interaction of isosafrole in vivo with rat hepatic microsomal cytochrome P-450 following treatment with phenobarbitone or 20-methylcholanthrene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

The interaction of aliphatic analogs of methylene-dioxyphenyl compounds with cytochromes P-450 and P-420.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Novel Drug Metabolites Produced by Functionalization Reactions: Chemistry and Toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Diethylaminoethyl 2,2-diphenylvalerate HCl (SKF 525-A)—In vivo and in vitro effects of metabolism by rat liver microsomes—Formation of an oxygenated complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Cytochrome P450 product complexes and glutathione consumption produced in isolated hepatocytes by norbenzphetamine and its N-oxidized congeners

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

In vivo and in vitro inhibition of the metabolism of N-alkyl-substituted amphetamines in rat by ferrocenylisopropylamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Interaction of aliphatic N-hydroxylamines with microsomal cytochrome P450: Nature of the different derived complexes and inhibitory effects on monoxygenases activities

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

The Formation of Cytochrome P-450-Metabolic Intermediate Complexes from Amines, in the Isolated Perfused Rat Liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Factors affecting drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

A new class of inhibitory cytochrome P-450 complexes formed during metabolism: a comparison with amphetamine and SKF 525-A type complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Formation of Complexes between Microsomal Cytochrome P-450-Fe(II) and Nitrosoarenes Obtained by Oxidation of Arylhydroxylamines or Reduction of Nitroarenes in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Effect of aromatic nitro compounds on oxidative metabolism by cytochrome P-450 dependent enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Studies on the cytochrome P-450 product complexes formed during the metabolism of N,N-dimethylaniline.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Binding of nitrosamines to cytochrome P-450 of liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Effects of short-term administration of nitrosamines on rat hepatic microsomal enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Inhibition of oxidative drug metabolism in microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Mechanism of in vivo carbon tetrachloride-induced liver microsomal cytochrome P-450 destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Electron spin resonance study of homolytic cleavage of carbon tetrachloride in rat liver: Pentadienyl free radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Degradation of cytochrome P-450 haem by carbon tetrachloride and 2-allyl-2-isopropylacetamide in rat liver in vivo and in vitro. Involvement of non-carbon monoxide-forming mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: Role of cytochrome P-450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Deuterium isotope effect in in vivo bioactivation of chloroform to phosgene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

The role of metabolism in chloroform hepatotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Comparison of the biochemical alterations elicited in livers from rats treated with carbon tetrachloride, chloroform, 1,1,2-trichloroethane and 1,1,1-trichloroethane

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Inhibition, activation, destruction, and induction of drug-metabolizing enzymes by trichloroethylene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

The effect of allyl compounds on hepatic microsomal mixed function oxidation and porphyrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Destruction of cytochrome P-450 by 2-isopropyl-4-pentenamide and methyl 2-isopropyl-4-pentenoate: Mass spectrometric characterization of prosthetic heme adducts and nonparticipation of epoxide metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Metabolic activation of acetylenic substituents to derivatives in the rat causing the loss of hepatic cytochrome P-450 and haem

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Metabolic oxidation of the ethynyl group in 4-ethynylbiphenyl

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

The metabolic oxidation of the ethynyl group in 4-ethynylbiphenyl in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Self-catalyzed destruction of cytochrome P-450: covalent binding of ethynyl sterols to prosthetic heme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

New drug metabolism inhibitor of marine origin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Cyclopropylamines as suicide substrates for cytochromes P-450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Inhibition of hepatic mixed-function oxidase activity in vitro and in vivo by various thiono-sulfur-containing compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

In vivo and in vitro effects of thiuram disulfides and dithiocarbamates on hepatic microsomal drug metabolism in the rat*1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Impairment of hepatic mixed-function oxidase activity by α- and β-naphthylisothiocyanate: Relationship to hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Evidence for the involvement of cytochrome P-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Investigation of the mechanism of the metabolic activation of chloramphenicol by rat liver microsomes. Identification of a new metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Role of Trace Metals in Regulation of Cellular Heme and Hemoprotein Metabolism: Sensitizing Effects of Chronic Iron Treatment on Acute Gold Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Cobalt as a modifier of microsomal monooxygenases in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Lead and Polychlorinated Biphenyls: Effects on Heme and Drug Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Prolonged induction of hepatic haem oxygenase and decreases in cytochrome P-450 content by organotin compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Interactions between nutritional factors and drug biotransformations in man

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Metabolic basis for the supra-additive effect of the ethanol-diazepam combination in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Interactions of Antiepileptic Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Drug interactions and clinical pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Cimetidine: interaction with oral anticoagulants in man

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Cimetidine/diazepam interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

The effect of chloramphenicol and sulphaphenazole on the biotransformation of cyclophosphamide in man

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Interaction between antipyrine and aminopyrine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

Effect of monoamine oxidase inhibitors on the n-demethylation and hydrolysis of meperidine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602538109011082

10.3109/03602538109011082

21 January 2018

Identifiers

DOI

1 reference

19 September 2017

1 reference

PubMed ID

7028434