(Q39500818)

12 September 2017

1 reference

title

Novel Drug Metabolites Produced by Functionalization Reactions: Chemistry and Toxicology (English)

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

4 November 2022

author name string

Testa B

1

1 reference

12 September 2017

Jenner P

2

1 reference

12 September 2017

language of work or name

English

0 references

publication date

1 January 1978

1 reference

full work available at URL

12 September 2017

http://www.tandfonline.com/doi/pdf/10.3109/03602537808993771

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

4 November 2022

published in

Drug Metabolism Reviews

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12 September 2017

volume

7

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12 September 2017

issue

2

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12 September 2017

page(s)

325-369

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Some mechanisms operative in carcinogenesis a review

12 September 2017

cites work

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21 January 2018

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The role of aflatoxin metabolism in its toxic lesion

21 January 2018

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Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential

21 January 2018

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Epoxide-diol pathway in the metabolism of tricyclic drugs

21 January 2018

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Formation of stable epoxides in the metabolism of tricyclic drugs

21 January 2018

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Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds.

21 January 2018

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Polycyclic K-region arene oxides. Products and kinetics of solvolysis

21 January 2018

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Reactions of the K-region oxides of carcinogenic and related polycyclic hydrocarbons with nucleophiles: stereochemistry and regioselectivity.

21 January 2018

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Glutathione Conjugates as Metabolites of Benz[a]anthracene

21 January 2018

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Hydration of arene and alkene oxides by epoxide hydrase in human liver microsomes

21 January 2018

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Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse skin

21 January 2018

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Reactivity of the K-region epoxides of some polycyclic hydrocarbons towards the nucleic acids and proteins of BHK 21 cells

21 January 2018

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Different pathways involved in the metabolism of the 7.8- and 9, 10-dihydrodiols of benzo(a)pyrene

21 January 2018

1 reference

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Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene

21 January 2018

1 reference

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Microsomal mixed-function oxidases and epoxide hydratase convert benzo(a)pyrene stereospecifically to optically active dihydroxydihydrobenzo(a)pyrenes

21 January 2018

1 reference

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Absolute configuration of a ribonucleic acid adduct formed in vivo by metabolism of benzo[a]pyrene

21 January 2018

1 reference

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Absolute sterochemistry of the highly mutagenic 7,8-diol 9,10-epoxides derived from the potent carcinogen trans-7,8-dihydroxy-7,8-dihydrobenzol[a]pyrene

21 January 2018

1 reference

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Letter: Benzo[a]pyrene-nucleic acid derivative found in vivo: structure of a benzo[a]pyrenetetrahydrodiol epoxide-guanosine adduct

21 January 2018

1 reference

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Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides

21 January 2018

1 reference

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Metabolism of benzo[a]pyrene. VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Mutagenicity of metabolically activated benzo[a]anthracene 3,4-dihydrodiol: evidence for bay region activation of carcinogenic polycyclic hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Transannular dioxygenation of 9,10-dimethyl-1,2-benzanthracene by cytochrome P-450 oxygenase of rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Studies on antiprotozoans. 3. Isolation, identification and quantitative determination in humans of the metabolites of a new trichomonacidal agent

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

The disposition and metabolism of I.C.I. 58,834 (viloxazine) in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Identification of Doxapram Metabolites using High Pressure Ion Exchange Chromatography and Mass Spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Identification of beta-hydroxyethoxyacetic acid as the major urinary metabolite of 1,4-dioxane in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Tissue metabolites of trifluoperazine, fluphenazine, prochlorperazine, and perphenazine in the rat: indentification and synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Identification of 2,6-dichlorophenylguanidine as a metabolite of clonidine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Differentiation of various types of biological oxidation of nitrogen in organic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

N-oxidation of primary and secondary amines to give hydroxylamines--a general metabolic route.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Metabolism of amitriptyline, nortriptyline, imipramine and desipramine to yield hydroxylamines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

The metabolism of dibenzylamine: identification of NN-dibenzylhydroxylamine as the major in vitro metabolic product from rabbit fortified hepatic homogenates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Oxidation of aliphatic hydroxylamines in aqueous solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

The microsomal N-oxidation of phentermine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

The identification of three new metabolic products of phentermine after liver microsomal incubation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Metabolic incorporation of oxygen into primary and secondary aliphatic amines and the consequences in carbon-nitrogen bond cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Oxaziridines as possible intermediates in flavin monooxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

The indentification of four metabolic products after incubation of p-methoxyamphetamine with liver preparations of various species.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Species Variations in the Metabolism of Acetophenone Oxime by Hepatic Enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

N-ethyl-alpha-methyl-alpha-(m-trifluoromethylbenzyl)nitrone--the major in vitro metabolic product of fenfluramine in guinea-pig liver microsomal fractions.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Formation and reduction of a nitroxide radical by liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

The mutagenicity of cyclamates and their metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

The relative rates of formation of the phenolic metabolites of mepivacaine in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Generation of reactive metabolites of N-hydroxy-phenacetin by glucuronidation and sulfation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Detection of arylhydroxylamines as intermediates in the metabolic reduction of nitro compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Nitroreduction of carcinogenic 5-nitrothiophenes by rat tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Mechanism of 2-Naphthylamine Oxidation Catalysed by Pig Liver Microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Isoniazid and Iproniazid: Activation of Metabolites to Toxic Intermediates in Man and Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Fragmentation reaction of ylide. 5. A new metabolic reaction of aziridine derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

S-oxidation of thioureylenes catalyzed by a microsomal flavoprotein mixed-function oxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Metabolic Oxidation of Aliphatic Basic Nitrogen Atoms and their α-Carbon Atoms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Cannabinol: a rapidly formed metabolite of delta-1- and delta-6-tetrahydrocannabinol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Conversion of N-alkylaminobenzophenones to benzodiazepines in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Comparison of the mechanisms of solvolysis and rearrangement of K-region vs. non-K-region arene oxides of phenanthrene. Comparative solvolytic rate constants of K-region and non-K-region arene oxides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Hepatic necrosis caused by furosemide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602537808993771

Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure

21 January 2018

3

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Covalent Binding: Useful Index of the Formation of Chemically Reactive Drug Metabolites

4 November 2022

4

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

4 November 2022

Chemical Society Reviews

8

12

145

Nery R

1976

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Aflatoxin B1-2,3-oxide: evidence for its formation in rat liver in vivo and by human liver microsomes in vitro

4 November 2022

14

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

"Epoxide-diol" metabolic pathway of 5H-dibenzo[a,d]cycloheptene in the rat. Studies by gas chromatography and mass spectrometry

4 November 2022

22

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Epoxides derived from various polycyclic hydrocarbons as substrates of homogeneous and microsome-bound epoxide hydratase. A general assay and kinetic properties

4 November 2022

30

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Dihydrodiols from anthracene and phenanthrene

4 November 2022

31

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Substrates and inhibitors of hepatic glutathione-S-epoxide transferase

4 November 2022

33

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

The conversion of benzo[a]pyrene 4,5-oxide into 4-hydroxybenzo[a]pyrene in the presence of polyriboguanylic acid

4 November 2022

37

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Epoxides as Reactive Intermediates in Aromatic Hydrocarbon Metabolism

4 November 2022

40

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Carbonium ion as ultimate carcinogen of polycyclic aromatic hydrocarbons

4 November 2022

46

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Phenolic and ketonic tautomers in polycyclic aromatic hydrocarbons

4 November 2022

54

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Mass spectrometry of cyclopenta[alpha]phenanthrenes. Metabolites formed in vitro and in vivo from the carcinogen 15,16-dihydro-11-methyl-cyclopenta[alpha]phenanthren-17-one

4 November 2022

57

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Determination of pinazepam and its metabolites in serum, urine and brain by gas—liquid chromatography and mass spectrometry

4 November 2022

60

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Studies on the Metabolism of Diethylnitrosamine in the Rat

4 November 2022

61

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Enzymatic formation of chemically reactive metabolites of N-nitroso-desmethyl tripelennamine by a mechanism other than N-dealkylation

4 November 2022

64

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Identification of a urinary metabolite of perazine as a piperazine-2,5-dione derivative

4 November 2022

73

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Formation of identical metabolites from piperazine- and dimethylamino-substituted phenothiazine drugs in man, rat and dog

4 November 2022

75

1 reference

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4 November 2022

Pharmacological Reviews

81

21

325

Bickel M. H

1969

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N-Hydroxylation of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane by rabbit liver microsomes

4 November 2022

86

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Species variations in the N-oxidation of chlorphentermine

4 November 2022

89

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Properties of a NADH-dependent N-hydroxy amine reductase isolated from pig liver microsomes

4 November 2022

90

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Autoxidation of N-hydroxyphenylalkylamines: the inhibitory effect of some anions on copper catalysed autoxidation of N-hydroxyphentermine

4 November 2022

94

1 reference

https://api.crossref.org/works/10.3109/03602537808993771

Derivatization to stabilize some aliphatic primary hydroxylamines for g.l.c. analysis

4 November 2022

95

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Modulation of the respiratory depressant effect of ethanol by 5-hydroxytryptamine

4 November 2022

102

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Role of the microsomal mixed-function amine oxidase in the oxidation of N,N-disubstituted hydroxylamines

4 November 2022

107

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The structure of nitrones derived from amphetamines

4 November 2022

109

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https://api.crossref.org/works/10.3109/03602537808993771

The nature of the "455 nm absorbing complex" formed during the cytochrome P450 dependent oxidative metabolism of amphetamine

4 November 2022

111

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https://api.crossref.org/works/10.3109/03602537808993771

Metabolism of 1,4-dihydro-6-trifluoromethylquinoxaline-2,3-dione (Lilly 72525) in rats and cats

4 November 2022

115

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4 November 2022

Pharmacological Reviews

117

25

1

Weisburger J. H.

1973

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Identification of the persistently bound form of the carcinogen N-acetyl-2-aminofluorene to rat liver DNA in vivo

4 November 2022

120

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Electrophilic N-acetoxyaminoarenes derived from carcinogenic N-hydroxy-N-acetylaminoarenes by enzymatic deacetylation and transacetylation in liver☆

4 November 2022

123

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Evidence for a second arylhydroxamic acid acyltransferase species in the small intestine of the rat

4 November 2022

124

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https://api.crossref.org/works/10.3109/03602537808993771

Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity

4 November 2022

126

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https://api.crossref.org/works/10.3109/03602537808993771

N-Hydroxylation of p-acetophenetidide as a factor in nephrotoxicity

4 November 2022

128

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https://api.crossref.org/works/10.3109/03602537808993771

Metabolic N-oxidation of secondary and primary aromatic amines as a route to ring hydroxylation, to various N-oxygenated products, and to dealkylation of secondary amines

4 November 2022

132

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Microsomal oxidase. IV. Properties of a mixed-function amine oxidase isolated from pig liver microsomes

4 November 2022

137

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4 November 2022

Identifiers

1 reference

release_ptovllvfcjdu5m367annjvioyy

12 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ptovllvfcjdu5m367annjvioyy

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference