(Q28291371)

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FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation

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FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation (English)

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phosphorylation

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author name string

William H Stoothoff

1

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Jae-Hyeon Cho

2

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Roy P McDonald

3

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Gail V W Johnson

4

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language of work or name

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publication date

7 January 2005

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Journal of Biological Chemistry

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280

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1

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270-6

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The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

1 reference

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21 January 2018

The glamour and gloom of glycogen synthase kinase-3

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21 January 2018

Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event

1 reference

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21 January 2018

Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling

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21 January 2018

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

1 reference

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21 January 2018

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

1 reference

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21 January 2018

Biochemical interactions in the wnt pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Characterization and functional analysis of the murine Frat2 gene.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

In vivo analysis of Frat1 deficiency suggests compensatory activity of Frat3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Glycogen synthase kinase-3 beta mutagenesis identifies a common binding domain for GBP and Axin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Identification of the Axin and Frat binding region of glycogen synthase kinase-3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage

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21 January 2018

MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Microtubule-associated protein tau, paired helical filaments, and phosphorylation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Regulation of GSK-3: a cellular multiprocessor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410061200

21 January 2018

Identifiers

10.1074/JBC.M410061200

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