(Q53215353)

12 May 2018

title

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology. (English)

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12 May 2018

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3

Binder LI

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12 May 2018

author name string

Carmel G

series ordinal

1

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12 May 2018

Mager EM

series ordinal

2

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12 May 2018

Kuret J

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4

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12 May 2018

language of work or name

English

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publication date

1 December 1996

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12 May 2018

Journal of Biological Chemistry

published in

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12 May 2018

volume

271

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12 May 2018

issue

51

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12 May 2018

page(s)

32789-32795

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12 May 2018

A neuronal antigen in the brains of Alzheimer patients

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Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

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Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

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Localization of the Alz-50 epitope in recombinant human microtubule-associated protein tau

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Binding of Alz 50 depends on Phe8 in tau synthetic peptides and varies between native and denatured tau proteins.

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Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

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Mapping of the Alz 50 epitope in microtubule-associated proteins tau

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Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease

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Alz-50 antibody recognizes Alzheimer-related neuronal changes

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The distribution of tau in the mammalian central nervous system

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Phosphorylation determines two distinct species of Tau in the central nervous system

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Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes

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Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease

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Epitopes that span the tau molecule are shared with paired helical filaments.

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DNA Restriction Enzyme from E. coli

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Two genes in Saccharomyces cerevisiae encode a membrane-bound form of casein kinase-1

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A solid-phase screen for protein kinase substrate selectivity

21 January 2018

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Protein volumes and hydration effects. The calculations of partial specific volumes, neutron scattering matchpoints and 280-nm absorption coefficients for proteins and glycoproteins from amino acid sequences.

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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A linear equation that describes the steady-state kinetics of enzymes and subcellular particles interacting with tightly bound inhibitors

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Application of synthetic phospho- and unphospho- peptides to identify phosphorylation sites in a subregion of the tau molecule, which is modified in Alzheimer's disease.

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21 January 2018

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Subunit structure of paired helical filaments in Alzheimer's disease

21 January 2018

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The organization of the microtubule associated protein tau in Alzheimer paired helical filaments

21 January 2018

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Alzheimer paired helical filaments, untreated and pronase digested, studied by vertical platinum-carbon replication and high resolution transmission electron microscopy.

21 January 2018

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Biochemical assay of Alzheimer's disease--associated protein(s) in human brain tissue. A clinical study.

21 January 2018

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Monoclonal antibody Alz-50 reacts with bovine and human serum albumin.

21 January 2018

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FAC1, a novel gene identified with the monoclonal antibody Alz50, is developmentally regulated in human brain

21 January 2018

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Tau protein and the neurofibrillary pathology of Alzheimer's disease

21 January 2018

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Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution

21 January 2018

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Activation of phospholipase C-gamma by the concerted action of tau proteins and arachidonic acid

21 January 2018

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Structure and novel exons of the human tau gene

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.271.51.32789

1 reference

12 May 2018

1 reference

12 May 2018