(Q28294604)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558078%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

review article

1 reference

title

Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558078%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

ChEBI release 2020-05-28

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558078%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

author name string

A J Harwood

series ordinal

1

0 references

language of work or name

English

0 references

publication date

1 January 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558078%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558078%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558078%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558078%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

page(s)

117-126

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558078%20AND%20SRC:MED&resulttype=core&format=json

Neural and developmental actions of lithium: a unifying hypothesis

5 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Search for a common mechanism of mood stabilizers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Reduced Brain Inositol in Lithium-treated Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Increased brain myo-inositol 1-phosphate in lithium-treated rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Biosynthesis of myo-inositol in rat mammary gland. Isolation and properties of the enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Structure and mechanism of inositol monophosphatase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Inositol 1,4,5-trisphosphate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

How versatile are inositol phosphate kinases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Lithium and valproate decrease inositol mass and increase expression of the yeast INO1 and INO2 genes for inositol biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

A common mechanism of action for three mood-stabilizing drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

The effect of lithium on expression of genes for inositol biosynthetic enzymes in mouse hippocampus; a comparison with the yeast model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Valproate decreases inositol biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

The high affinity inositol transport system--implications for the pathophysiology and treatment of bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Differential expression, activity and regulation of the sodium/myo-inositol cotransporter in astrocyte cultures from different regions of the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Regulated exocytosis of an H+/myo-inositol symporter at synapses and growth cones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Chronic treatment with lithium and pretreatment with excess inositol reduce inositol pool size in astrocytes by different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Loss of murine Na+/myo-inositol cotransporter leads to brain myo-inositol depletion and central apnea

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

In vivo brain myo-inositol levels in children with Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Inositol monophosphatase--a putative target for Li+ in the treatment of bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

A novel mammalian lithium-sensitive enzyme with a dual enzymatic activity, 3'-phosphoadenosine 5'-phosphate phosphatase and inositol-polyphosphate 1-phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Tol1, a fission yeast phosphomonoesterase, is an in vivo target of lithium, and its deletion leads to sulfite auxotrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Comparison of rate constants for (PO3-) transfer by the Mg(II), Cd(II), and Li(I) forms of phosphoglucomutase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Identification of human phosphoglucomutase 3 (PGM3) as N-acetylglucosamine-phosphate mutase (AGM1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

A molecular mechanism for the effect of lithium on development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Lithium inhibits glycogen synthase kinase-3 by competition for magnesium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Developmental biology: How neurons avoid derailment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Wnt signaling went derailed again: a new track via the LIN-18 receptor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Lithium stimulates accumulation of second-messenger inositol 1,4,5-trisphosphate and other inositol phosphates in mouse pancreatic minilobules without inositol supplementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Effect of valproic acid on serotonin-2A receptor signaling in C6 glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Intracerebroventricular myo-inositol antagonizes lithium-induced suppression of rearing behaviour in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Magnetic resonance spectroscopy in affective disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Measurement of brain phosphoinositide metabolism in bipolar patients using in vivo 31P-MRS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Reduced inositol content in lymphocyte-derived cell lines from bipolar patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Incorporation of inositol into the phosphoinositides of lymphoblastoid cell lines established from bipolar manic-depressive patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and on cholinergic and peptidergic neurons in rats with ibotenate-induced lesions of the nucleus basalis magnocellularis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

ZTTA, a postproline cleaving enzyme inhibitor, improves cerebral ischemia-induced deficits in a three-panel runway task in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Lower serum prolyl endopeptidase enzyme activity in major depression: further evidence that peptidases play a role in the pathophysiology of depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Alterations in plasma prolyl endopeptidase activity in depression, mania, and schizophrenia: effects of antidepressants, mood stabilizers, and antipsychotic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Inositol phosphate biochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

In vivo measurement of lithium in humans by nuclear magnetic resonance spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Chronic lithium treatment of B lymphoblasts from bipolar disorder patients reduces transient receptor potential channel 3 levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Chronic lithium treatment attenuates intracellular calcium mobilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

The extended protein kinase C superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Membrane phospholipid degradation and protein kinase C for cell signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Lithium treatment inhibits protein kinase C translocation in rat brain cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Increased association of brain protein kinase C with the receptor for activated C kinase-1 (RACK1) in bipolar affective disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Chronic lithium administration alters a prominent PKC substrate in rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Regulation of chromatin remodeling by inositol polyphosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Second messenger control of chromatin remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

PDK1, the master regulator of AGC kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

A unified hypothesis on the lineage of neural stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Functional neurogenesis in the adult hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

A molecular cell biology of lithium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

The neuropathology of primary mood disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

Lithium compared to valproic acid and carbamazepine in the treatment of mania: a statistical meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

Cellular localization of Na+/MYO-inositol co-transporter mRNA in the rat brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

Signal transduction: Life, the universe and ... development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

The effects of lithium on myo-inositol levels in layers of frontal cerebral cortex, in cerebellum, and in corpus callosum of the rat

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

Evidence that Lithium Alters Phosphoinositide Metabolism: Chronic Administration Elevates Primarily d-myo-Inositol-1-Phosphate in Cerebral Cortex of the Rat

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

Li+ increases accumulation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in cholinergically stimulated brain cortex slices in guinea pig, mouse and rat. The increases require inositol supplementation in mouse and rat but not

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

A novel action of lithium: stimulation of glutamate release and inositol 1,4,5 trisphosphate accumulation via activation of the N-methyl D-aspartate receptor in monkey and mouse cerebral cortex slices

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

Scyllo-inositol in post-mortem brain of bipolar, unipolar and schizophrenic patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

Effects of lithium on platelet membrane phosphoinositides in bipolar disorder patients: a pilot study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

Neurogenesis in adult mammals: some progress and problems.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

Chronic lithium-induced down-regulation of MARCKS in immortalized hippocampal cells: potentiation by muscarinic receptor activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilisers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001618

7 January 2021

Identifiers

DOI

10.1038/SJ.MP.4001618

2 references

Consolidated OpenCitations Corpus – April 2017

1524522

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558078%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1524522

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

1524522

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558078%20AND%20SRC:MED&resulttype=core&format=json