(Q28301344)

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Clinical outcome of de novo acute myeloid leukaemia patients with normal cytogenetics is affected by molecular genetic alterations: a concise review

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Europe PubMed Central

Clinical outcome of de novo acute myeloid leukaemia patients with normal cytogenetics is affected by molecular genetic alterations: a concise review (English)

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3

object named as

Guido Marcucci

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Clara D. Bloomfield

4

object named as

Clara D Bloomfield

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Krzysztof Mrózek

2

object named as

Krzysztof Mrózek

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Claudia D Baldus

1

object named as

Claudia D Baldus

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publication date

June 2007

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British Journal of Haematology

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137

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5

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387-400

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Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype

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Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)

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Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

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Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

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CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations

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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

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Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

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Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia

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A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG

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The role of FLT3 in haematopoietic malignancies

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BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia

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Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).

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Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

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BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a Cancer and Leukemia Group B Study

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Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genes

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BAALC expression and FLT3 internal tandem duplication mutations in acute myeloid leukemia patients with normal cytogenetics: prognostic implications

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High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults.

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Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.

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FLT3 mutation and response to intensive chemotherapy in young adult and elderly patients with normal karyotype

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Risk assessment in patients with acute myeloid leukemia and a normal karyotype

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Cancer and leukemia group B leukemia correlative science committee: major accomplishments and future directions

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Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia

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Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics

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Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm.

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Acute myeloid leukaemia

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Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.

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Outcome of induction and postremission therapy in younger adults with acute myeloid leukemia with normal karyotype: a cancer and leukemia group B study

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Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.

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MLL: a histone methyltransferase disrupted in leukemia

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Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal.

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Clinical importance of cytogenetics in acute myeloid leukaemia

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Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML.

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10.1111/J.1365-2141.2007.06566.X

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