(Q28302804)

English

Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects

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scholarly article

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Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects (English)

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cannabinoid receptor

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author name string

Stefan Raduner

1

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Adriana Majewska

2

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Jian-Zhong Chen

3

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Xiang-Qun Xie

4

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Jacques Hamon

5

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Bernard Faller

6

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Karl-Heinz Altmann

7

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Jürg Gertsch

8

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language of work or name

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publication date

19 May 2006

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Journal of Biological Chemistry

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281

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14192-206

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20

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Efficacy of a standardized echinacea preparation (Echinilin) for the treatment of the common cold: a randomized, double-blind, placebo-controlled trial

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Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt.,Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties

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21 January 2018

An evaluation of Echinacea angustifolia in experimental rhinovirus infections

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Echinaforce and other Echinacea fresh plant preparations in the treatment of the common cold. A randomized, placebo controlled, double-blind clinical trial.

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21 January 2018

Use of echinacea in medicine

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Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways

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21 January 2018

The endocannabinoid system as a target for alkamides from Echinacea angustifolia roots.

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The endocannabinoid system: a general view and latest additions

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Molecular characterization of a peripheral receptor for cannabinoids

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Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations

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Presence and regulation of the endocannabinoid system in human dendritic cells

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Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear.

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Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2Cannabinoid Receptors

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Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation

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Cannabinoid-based drugs as anti-inflammatory therapeutics

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Cannabinoids and the immune system: potential for the treatment of inflammatory diseases?

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Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice.

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3D structural model of the G‐protein‐coupled cannabinoid CB2 receptor

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Bioavailability and pharmacokinetics of alkamides from the roots of Echinacea angustifolia in humans

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Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion

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Control of pain initiation by endogenous cannabinoids.

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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Crystal structure of rhodopsin: A G protein-coupled receptor

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Targeting the cannabinoid CB2 receptor: mutations, modeling and development of CB2 selective ligands.

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Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor

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Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR 141716A.

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Mutational analysis and molecular modelling of the antagonist SR 144528 binding site on the human cannabinoid CB(2) receptor

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A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognition

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Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells

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Cachectin and tumour necrosis factor as two sides of the same biological coin

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Antigen-independent Th2 cell differentiation by stimulation of CD28: regulation via IL-4 gene expression and mitogen-activated protein kinase activation

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Phospholipase C-gamma 1 association with CD3 structure in T cells

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Preferred conformations of endogenous cannabinoid ligand anandamide

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An Aromatic Microdomain at the Cannabinoid CB1 Receptor Constitutes an Agonist/Inverse Agonist Binding Region

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Cannabinoid agonists induce contractile responses through Gi/o-dependent activation of phospholipase C in the bovine ciliary muscle

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Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors

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Cannabinoid receptor-mediated regulation of intracellular calcium by delta(9)-tetrahydrocannabinol in resting T cells

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The endogenous cannabinoid anandamide potentiates interleukin-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor-mediated pathway

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The two faces of IL-6 on Th1/Th2 differentiation

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Directing transition from innate to acquired immunity: defining a role for IL-6.

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Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60

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2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells

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21 January 2018

Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway.

1 reference

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Anandamide initiates Ca(2+) signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells

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Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes

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2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2.

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A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo.

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Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

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21 January 2018

Identifiers

10.1074/JBC.M601074200

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https://api.fatcat.wiki/v0/release/6e4x2wszcnbwzdnehbqt22j7ge

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