(Q28345244)

2

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V H Brophy

3

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A Rosowsky

4

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C H Sibley

Antimicrobial Agents and Chemotherapy

5

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language of work or name

English

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publication date

January 2001

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published in

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volume

45

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issue

1

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page(s)

187-95

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cites work

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Structure-based design of selective inhibitors of dihydrofolate reductase: synthesis and antiparasitic activity of 2, 4-diaminopteridine analogues with a bridged diarylamine side chain

20 March 2017

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Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim

20 March 2017

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In search of dihydrofolate reductase

20 March 2017

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Identification of highly potent and selective inhibitors of Toxoplasma gondii dihydrofolate reductase

20 March 2017

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Nucleotide sequence of the dihydrofolate reductase gene of Saccharomyces cerevisiae

20 March 2017

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A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

20 March 2017

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The phenotype of a dihydrofolate reductase mutant of Saccharomyces cerevisiae

20 March 2017

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Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania

20 March 2017

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Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain.

29 September 2017

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Community pyrimethamine-sulfadoxine use and prevalence of resistant Plasmodium falciparum genotypes in Mali: a model for deterring resistance

29 September 2017

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Potential antifolate resistance determinants and genotypic variation in the bifunctional dihydrofolate reductase-thymidylate synthase gene from human and bovine isolates of Cryptosporidium parvum

29 September 2017

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Eukaryotic dihydrofolate reductase

29 September 2017

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High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size

29 September 2017

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The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.

29 September 2017

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Inhibition of folate biosynthesis and function as a basis for chemotherapy

29 September 2017

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In vitro activities of and mechanisms of resistance to antifol antimalarial drugs

29 September 2017

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Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

29 September 2017

1 reference

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Isolation and expression of the Pneumocystis carinii dihydrofolate reductase gene

29 September 2017

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The dihydrofolate reductase-thymidylate synthetase gene in the drug resistance of malaria parasites

29 September 2017

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Chemotherapy and immunity in opportunistic parasitic infections in AIDS.

29 September 2017

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Methotrexate analogs. 8. Synthesis and biological evaluation of bisamide derivatives as potential prodrugs

29 September 2017

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Identification and analysis of dihydrofolate reductase alleles from Plasmodium falciparum present at low frequency in polyclonal patient samples.

29 September 2017

1 reference

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Molecular epidemiology of malaria in Yaounde, Cameroon I. Analysis of point mutations in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

2 June 2018

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2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

2 June 2018

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Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90259

2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90259

Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90259

2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90259

2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii

2 June 2018

1 reference

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2,4-Diamino-5-chloroquinazoline analogues of trimetrexate and piritrexim: synthesis and antifolate activity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90259

2,4-Diaminopyrido[3,2-d]pyrimidine inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90259

Methotrexate analogs. 3. Synthesis and biological properties of some side-chain altered analogs.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90259

Expression and site-directed mutagenesis of human dihydrofolate reductase.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90259

Observations on monthly pyrimethamine (daraprim) prophylaxis in an East African village.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90259

A biochemical and genetic model for parasite resistance to antifolates. Toxoplasma gondii provides insights into pyrimethamine and cycloguanil resistance in Plasmodium falciparum.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90259

Pteridines. 2. New 6,7-disubstituted pteridines as potential antimalarial and antitumor agents.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90259

Methotrexate analogs. 6. Replacement of glutamic acid by various amino acid esters and amines

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11120964

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Yeast as a model system to study drugs effective against apicomplexan proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11120964