(Q28346934)

1

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R A Mathôt

2

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M M Tibben

3

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J H Schellens

4

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S Rodenhuis

British Journal of Clinical Pharmacology

5

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language of work or name

English

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publication date

January 2001

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published in

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volume

51

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issue

1

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page(s)

61-70

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cites work

Biotransformation of N,N',N''-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N''-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase

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Prediction of creatinine clearance from serum creatinine

20 March 2017

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Dose escalation of N,N',N"-triethylenethiophosphoramide combined with pentoxifylline for advanced breast cancer.

7 April 2017

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High-dose chemotherapy regimens for solid tumors

29 September 2017

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Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid

29 September 2017

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Phase I/pharmacokinetic reevaluation of thioTEPA

29 September 2017

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Phase I trial of thiotepa in combination with recombinant human granulocyte-macrophage colony-stimulating factor

29 September 2017

1 reference

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Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.

29 September 2017

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The importance of modeling interoccasion variability in population pharmacokinetic analyses

2 June 2018

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Pharmacokinetics of thio-TEPA at two different doses.

2 June 2018

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Cellular pharmacology of N,N',N''-triethylene thiophosphoramide

2 June 2018

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Phase I and pharmacokinetic evaluation of thiotepa in the cerebrospinal fluid and plasma of pediatric patients: evidence for dose-dependent plasma clearance of thiotepa.

2 June 2018

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Dosing of thioTEPA for myeloablative therapy

2 June 2018

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Evidence for enzymatic activation and oxygen involvement in cytotoxicity and antitumor activity of N,N',N''-triethylenethiophosphoramide

21 January 2018

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N,N',N''-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents

27 November 2018

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Pharmacokinetics of high dose thiotepa in children undergoing autologous bone marrow transplantation

27 November 2018

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Influence of co-medicated drugs on the biotransformation of thioTEPA to TEPA and thioTEPA-mercapturate

27 November 2018

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12 December 2020

Human plasma pharmacokinetics and urinary excretion of thiotepa and its metabolites

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12 December 2020

A phase I/II study of high-dose cyclophosphamide, cisplatin, and thioTEPA followed by autologous bone marrow and granulocyte colony-stimulating factor-primed peripheral-blood progenitor cells in patients with advanced malignancies

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12 December 2020

Feasibility of multiple courses of high-dose cyclophosphamide, thiotepa, and carboplatin for breast cancer or germ cell cancer

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12 December 2020

Oxidation of cyclophosphamide to 4-hydroxycyclophosphamide and deschloroethylcyclophosphamide in human liver microsomes

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12 December 2020

Simultaneous determination of N,N',N"-triethylenethiophosphoramide, cyclophosphamide and some of their metabolites in plasma using capillary gas chromatography

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12 December 2020

Sampling technique from central venous catheters proves critical for pharmacokinetic studies

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12 December 2020

A search for new metabolites of N,N',N''-triethylenethiophosphoramide

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12 December 2020

Single and repeated dose pharmacokinetics of thio-TEPA in patients treated for ovarian carcinoma

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12 December 2020

High-dose i.v. thiotepa and cryopreserved autologous bone marrow transplantation for therapy of refractory cancer

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12 December 2020

Pharmacokinetics of continuous-infusion high-dose thiotepa

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12 December 2020

The binding of thio-TEPA in human serum and to isolated serum protein fractions

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12 December 2020

Human plasma pharmacokinetics of thiotepa following administration of high-dose thiotepa and cyclophosphamide

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12 December 2020

Long-term pharmacokinetics of thio-TEPA, TEPA and total alkylating activity following i. v. bolus administration of thio-TEPA in ovarian cancer patients

1 reference

12 December 2020

Thiono compounds. 4. In vitro mutagenic and antineoplastic activity of TEPA and thio-TEPA

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12 December 2020

Pharmacokinetics of thio-TEPA and TEPA in the conventional dose-range and its correlation to myelosuppressive effects

1 reference

12 December 2020