(Q28360183)

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Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha)

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Europe PubMed Central

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5 November 2019

Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha) (English)

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5 November 2019

desensitization

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Louise E Donnelly

2

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5 November 2019

7

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5 November 2019

Maria G Belvisi

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M G Belvisi

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5 November 2019

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P A Finney

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5 November 2019

T T Chuang

4

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5 November 2019

M Birrell

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5 November 2019

A Harris

6

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5 November 2019

C Scorer

8

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5 November 2019

P J Barnes

9

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5 November 2019

I M Adcock

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5 November 2019

M A Giembycz

11

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5 November 2019

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1 March 2001

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5 November 2019

British Journal of Pharmacology

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5 November 2019

132

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5 November 2019

6

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5 November 2019

1261-1270

1 reference

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5 November 2019

Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

20 March 2017

Purification and characterization of the beta-adrenergic receptor kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

20 March 2017

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

20 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

beta-Arrestin: a protein that regulates beta-adrenergic receptor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

20 March 2017

Albuterol-induced downregulation of Gsalpha accounts for pulmonary beta(2)-adrenoceptor desensitization in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

Activation of the beta(2)-adrenergic receptor-Galpha(s) complex leads to rapid depalmitoylation and inhibition of repalmitoylation of both the receptor and Galpha(s).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

Probing the salmeterol binding site on the beta 2-adrenergic receptor using a novel photoaffinity ligand, [(125)I]iodoazidosalmeterol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

Dose equivalence and bronchoprotective effects of salmeterol and salbutamol in asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

Activation-induced subcellular redistribution of Gs alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

Agonist regulation of cellular G protein levels and distribution: mechanisms and functional implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

Protein kinases that phosphorylate activated G protein-coupled receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

Molecular mechanisms of membrane receptor desensitization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

Beta-adrenergic receptors and their regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

Protective effects of a glucocorticoid on downregulation of pulmonary beta 2-adrenergic receptors in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

Subsensitivity of bronchodilator and systemic beta 2 adrenoceptor responses after regular twice daily treatment with eformoterol dry powder in asthmatic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

Intravenous beta agonist in severe acute asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

Stimulation of beta-adrenergic receptors of S49 lymphoma cells redistributes the alpha subunit of the stimulatory G protein between cytosol and membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

A comparison of beta-adrenergic receptors and in vitro relaxant responses to isoproterenol in asthmatic airway smooth muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

In vivo desensitization to beta receptor mediated bronchodilator drugs in the rat: decreased beta receptor affinity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

29 September 2017

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

2 June 2018

Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

2 June 2018

Characterization of the prostaglandin E2 sensitive (EP)-receptor in the rat isolated trachea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

2 June 2018

Activation and depalmitoylation of Gs alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

2 June 2018

Ambulatory long-term subcutaneous salbutamol infusion in chronic severe asthma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

2 June 2018

Salmeterol, a novel, long-acting β2-adrenoceptor agonist: characterization of pharmacological activity in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

2 June 2018

Role of G protein-coupled receptor kinase 2 and arrestins in beta-adrenergic receptor internalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

27 November 2018

Duration of action of inhaled vs. Intravenous beta(2)-adrenoceptor agonists in an anaesthetized guinea-pig model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

27 November 2018

Induction of phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in beta2-adrenoreceptor desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

27 November 2018

Tolerance to the bronchoprotective effect of salmeterol in adolescents with exercise-induced asthma using concurrent inhaled glucocorticoid treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

27 November 2018

Comparison of human bronchial muscle responses to histamine in vivo with histamine and isoproterenol agonists in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572675

27 November 2018

Bronchodilator subsensitivity after chronic dosing with eformoterol in patients with asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential down-regulation of pulmonary beta 1- and beta 2-adrenoceptor messenger RNA with prolonged in vivo infusion of isoprenaline

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic isoproterenol administration causes altered beta adrenoceptor-Gs-coupling in guinea pig lung

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional and binding characteristics of long-acting beta 2-agonists in lung and heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of salmeterol xinafoate in laboratory animals and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term exposure to norepinephrine results in down-regulation and reduced mRNA expression of pulmonary beta-adrenergic receptors in guinea pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of inflammation and acute beta-agonist inhalation on beta 2-AR signaling in human airways

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The thyroliberin receptor interacts directly with a stimulatory guanine-nucleotide-binding protein in the activation of adenylyl cyclase in GH3 rat pituitary tumour cells. Evidence obtained by the use of antisense RNA inhibition and immunoblocking o

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the effects of salmeterol and formoterol on airway tone and responsiveness over 24 hours in bronchial asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term effects of a long-acting beta 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tolerance to the bronchoprotective effect of salmeterol 12 hours after starting twice daily treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long term treatment of severe asthma with subcutaneous terbutaline

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intravenous salbutamol in the treatment of status asthmaticus in children

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species and strain-related differences in the expression and functionality of beta-adrenoceptor subtypes in adipose tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tolerance to the protective effects of salmeterol on methacholine-induced bronchoconstriction: influence of inhaled corticosteroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of receptor kinases and arrestins in G protein-coupled receptor regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11250877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Versuchsanordnung zu Untersuchungen an der Bronchiàlmuskulatur

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0703946

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.BJP.0703946

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11250877%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

PMC publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11250877%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11250877%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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