(Q28364896)

English

Detection of receptor ligands by monitoring selective stabilization of a Renilla luciferase-tagged, constitutively active mutant, G-protein-coupled receptor

scientific article

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scholarly article

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Detection of receptor ligands by monitoring selective stabilization of a Renilla luciferase-tagged, constitutively active mutant, G-protein-coupled receptor (English)

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G protein-coupled receptor

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author name string

D Ramsay

1

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N Bevan

2

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S Rees

3

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G Milligan

4

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language of work or name

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publication date

May 2001

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British Journal of Pharmacology

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133

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2

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315-23

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Ligand regulation of green fluorescent protein-tagged forms of the human beta(1)- and beta(2)-adrenoceptors; comparisons with the unmodified receptors

1 reference

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29 September 2017

Using green fluorescent proteins to study G-protein-coupled receptor localization and trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

29 September 2017

Exploring the dynamics of regulation of G protein-coupled receptors using green fluorescent protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

29 September 2017

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

29 September 2017

Following cell fate in the living mouse embryo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

29 September 2017

Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

29 September 2017

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

29 September 2017

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

29 September 2017

A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

29 September 2017

Use of constitutive G protein-coupled receptor activity for drug discovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

2 June 2018

Visualizing differences in ligand regulation of wild-type and constitutively active mutant beta(2)-adrenoceptor-green fluorescent protein fusion proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

2 June 2018

Inverse agonism and the regulation of receptor number

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

2 June 2018

Regulation of spontaneous activity of the delta-opioid receptor: studies of inverse agonism in intact cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

2 June 2018

Up-regulation of the levels of expression and function of a constitutively active mutant of the hamster alpha1B-adrenoceptor by ligands that act as inverse agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

2 June 2018

Synergism of constitutive activity in alpha 1-adrenergic receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

2 June 2018

Inverse agonist-induced up-regulation of the human beta2-adrenoceptor in transfected neuroblastoma X glioma hybrid cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

2 June 2018

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

2 June 2018

Gi assays in transfected cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

2 June 2018

Inverse agonism and neutral antagonism at a constitutively active alpha-1a adrenoceptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572784

27 November 2018

The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H(2) receptor.

1 reference

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27 November 2018

Constitutively active G protein-coupled receptors: potential mechanisms of receptor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11350868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11350868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment

1 reference

https://pubmed.ncbi.nlm.nih.gov/11350868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Visualization of agonist-induced sequestration and down-regulation of a green fluorescent protein-tagged beta2-adrenergic receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11350868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist-independent regulation of constitutively active G-protein-coupled receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11350868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Review: amino acid domains involved in constitutive activation of G-protein-coupled receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11350868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resolution of inverse agonist-induced up-regulation from constitutive activity of mutants of the alpha(1b)-adrenoceptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11350868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11350868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJP.0704077

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