(Q28367605)

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5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile

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scholarly article

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5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile (English)

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author name string

S M Daluge

1

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D J Purifoy

2

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P M Savina

3

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M H St Clair

4

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N R Parry

5

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I K Dev

6

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P Novak

7

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K M Ayers

8

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J E Reardon

9

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G B Roberts

10

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language of work or name

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publication date

July 1994

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Antimicrobial Agents and Chemotherapy

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38

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7

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1590-603

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Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

20 March 2017

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

1 reference

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20 March 2017

Anti-HIV compound assessment by two novel high capacity assays

1 reference

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20 March 2017

Inhibition of HIV-replication by 3'-fluoro-modified nucleosides with low cytotoxicity

1 reference

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20 March 2017

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

1 reference

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20 March 2017

HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy

1 reference

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20 March 2017

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

1 reference

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20 March 2017

Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity

1 reference

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20 March 2017

Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase

1 reference

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20 March 2017

Zidovudine-resistant human immunodeficiency virus selected by passage in cell culture

1 reference

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20 March 2017

Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells

1 reference

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20 March 2017

Human immunodeficiency virus reverse transcriptase. Substrate and inhibitor kinetics with thymidine 5'-triphosphate and 3'-azido-3'-deoxythymidine 5'-triphosphate

1 reference

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20 March 2017

Comparison of in vitro biological properties and mouse toxicities of three thymidine analogs active against human immunodeficiency virus

1 reference

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20 March 2017

Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine

1 reference

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20 March 2017

The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

20 March 2017

3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

20 March 2017

Statistical estimations in enzyme kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

7 April 2017

The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

7 April 2017

The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

7 April 2017

Computer Programmes for Processing Enzyme Kinetic Data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

29 September 2017

High-capacity in vitro assessment of anti-hepatitis B virus compound selectivity by a virion-specific polymerase chain reaction assay

1 reference

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29 September 2017

Future therapies in the management of critically ill AIDS patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

29 September 2017

Toxicity of 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for normal human hematopoietic progenitor cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

29 September 2017

Fitting curves to data using nonlinear regression: a practical and nonmathematical review

1 reference

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29 September 2017

Rapid and sensitive viral culture method for human immunodeficiency virus type 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

29 September 2017

Development of a sensitive quantitative focal assay for human immunodeficiency virus infectivity

1 reference

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29 September 2017

Preclinical toxicology of zidovudine. An overview.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

29 September 2017

Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

29 September 2017

Glucuronidation of 3'-azido-3'-deoxythymidine: human and rat enzyme specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

29 September 2017

Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay

1 reference

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29 September 2017

Safety and tolerance of dideoxycytidine as a single agent. Results of early-phase studies in patients with acquired immunodeficiency syndrome (AIDS) or advanced AIDS-related complex. Study Group of the AIDS Clinical Trials Group of the National Inst

1 reference

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29 September 2017

Activation of a beta-galactosidase recombinant provirus: application to titration of human immunodeficiency virus (HIV) and HIV-infected cells

1 reference

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29 September 2017

Human immunodeficiency virus reverse transcriptase. Effect of primer length on template-primer binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

29 September 2017

Mutant varicella-zoster virus thymidine kinase: correlation of clinical resistance and enzyme impairment

1 reference

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29 September 2017

Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation

1 reference

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29 September 2017

Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test

1 reference

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29 September 2017

Mutagenicities of N-nitrosamines on salmonella

1 reference

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29 September 2017

Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine

1 reference

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29 September 2017

Deoxythymidine pools of human skin and guinea pig organs

1 reference

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2 June 2018

5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

2 June 2018

Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

2 June 2018

5-Halogeno-3'-fluoro-2',3'-dideoxyuridines as inhibitors of human immunodeficiency virus (HIV): potent and selective anti-HIV activity of 3'-fluoro-2',3'-dideoxy-5-chlorouridine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=284598

2 June 2018

Cellular metabolism of 2',3'-dideoxycytidine, a compound active against human immunodeficiency virus in vitro

1 reference

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2 June 2018

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1 reference

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2 June 2018

Expression of mitochondrial cytochrome c oxidase in human colonic cell differentiation, transformation, and risk for colonic cancer

1 reference

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2 June 2018

The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection. A double-blind, placebo-controlled trial. The AIDS Clinical Trials Group

1 reference

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2 June 2018

Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases

1 reference

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2 June 2018

Glucuronidation of 3'-azido-3'-deoxythymidine catalyzed by human liver UDP-glucuronosyltransferase. Significance of nucleoside hydrophobicity and inhibition by xenobiotics

1 reference

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2 June 2018

A controlled trial comparing continued zidovudine with didanosine in human immunodeficiency virus infection. The NIAID AIDS Clinical Trials Group

1 reference

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2 June 2018

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1 reference

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1 reference

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2 June 2018

Thymidine concentrations in serum and urine of different animal species and man

1 reference

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Meanings of Ki for conventional and alternate-substrate inhibitors.

1 reference

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1 reference

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27 November 2018

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1 reference

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27 November 2018

Molecular Characterization of Human T-Cell Leukemia (Lymphotropic) Virus Type III in the Acquired Immune Deficiency Syndrome

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27 November 2018

A molecular clone of HTLV-III with biological activity.

1 reference

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27 November 2018

Testing for the equality of area under the curves when using destructive measurement techniques

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526782

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526782

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term toxicity/activity profile of 2',3'-dideoxyinosine in AIDS or AIDS-related complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526782

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of zidovudine (azidothymidine). II. Development of metabolic and renal clearance pathways in the neonate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526782

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane permeation characteristics of 5'-modified thymidine analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526782

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics and intermediates in the intracellular synthesis of bacteriophage T4 deoxyribonucleic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526782

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purine nucleobase transport in human erythrocytes. Reinvestigation with a novel “inhibitor-stop” assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526782

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and bioavailability of zidovudine in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526782

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enantiomeric selectivity of carbovir transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526782

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/7526782

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.38.7.1590

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