(Q28374493)

English

High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene

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High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene (English)

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R C Sills

1

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H L Hong

2

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R L Melnick

3

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G A Boorman

4

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T R Devereux

5

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language of work or name

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publication date

April 1999

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20

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4

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657-62

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Inhalation toxicology of isoprene in F344 rats and B6C3F1 mice following two-week exposures

1 reference

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21 January 2018

Inhalation toxicity studies with 1,3-butadiene. 3. Two year toxicity/carcinogenicity study in rats

1 reference

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21 January 2018

Tissue-mediated mutagenicity of vinylidene chloride and 2-chlorobutadiene in Salmonella typhimurium

1 reference

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21 January 2018

Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases

1 reference

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21 January 2018

Bacterial mutagenicity of 2-chloro-1,3-butadiene (chloroprene) caused by decomposition products.

1 reference

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21 January 2018

Aspects of the toxicology of chloroprene: immediate and long-term effects

1 reference

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21 January 2018

Chloroprene and isoprene: cytogenetic studies in mice.

1 reference

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21 January 2018

Results of NTP-sponsored mouse cytogenetic studies on 1,3-butadiene, isoprene, and chloroprene

1 reference

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21 January 2018

1 reference

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21 January 2018

Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse.

1 reference

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21 January 2018

Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains.

1 reference

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21 January 2018

Cellular and molecular mechanisms of multistep carcinogenesis: relevance to carcinogen risk assessment

1 reference

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21 January 2018

The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: perspective, prospects and problems

1 reference

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21 January 2018

Targeted A --> T and G --> T mutations induced by site-specific deoxyadenosine and deoxyguanosine adducts, respectively, from the (+)-anti-diol epoxide of dibenz[a,j]anthracene in M13mp7L2.

1 reference

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21 January 2018

Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks

1 reference

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21 January 2018

The reaction of 3,4-epoxy-1-butene with deoxyguanosine and DNA in vitro: synthesis and characterization of the main adducts.

1 reference

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21 January 2018

Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents

1 reference

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21 January 2018

Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months

1 reference

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21 January 2018

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1 reference

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21 January 2018

Ras proto-oncogene activation in liver and lung tumors from B6C3F1 mice exposed chronically to methylene chloride

1 reference

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21 January 2018

Specific patterns of oncogene activation in transplacentally induced tumors

1 reference

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21 January 2018

'Cold SSCP': a simple, rapid and non-radioactive method for optimized single-strand conformation polymorphism analyses

1 reference

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21 January 2018

Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells

1 reference

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21 January 2018

Mutagenicity of butadiene and its epoxide metabolites: II. Mutational spectra of butadiene, 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from exposed B6C3F1 mice.

1 reference

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21 January 2018

Molecular analysis of lacI mutants from bone marrow of B6C3F1 transgenic mice following inhalation exposure to 1,3-butadiene.

1 reference

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21 January 2018

Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: the role of apurinic sites

1 reference

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21 January 2018

Mutagenicity and chemical reactivity of epoxidic intermediates of the isoprene metabolism and other structurally related compounds.

1 reference

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21 January 2018

Dose-response relationships for carcinogens.

1 reference

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21 January 2018

The traditional toxicologic paradigm is correct: dose influences mechanism

1 reference

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21 January 2018

Dose-dependent differences in the profile of mutations induced by an ultimate carcinogen from benzo[a]pyrene.

1 reference

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21 January 2018

Identifiers

10.1093/CARCIN/20.4.657

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release_mt6eqxu4fbdw7emzb3wb5nasve

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24 November 2022

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