(Q28377626)

English

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis

scientific article published in April 2000

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scholarly article

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Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis (English)

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(S)-(−)-colchicine

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author name string

S J Haggarty

1

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T U Mayer

2

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D T Miyamoto

3

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R Fathi

4

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R W King

5

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T J Mitchison

6

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S L Schreiber

7

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language of work or name

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publication date

April 2000

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Chemistry and Biology

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7

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4

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275-86

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Chemical genetics resulting from a passion for synthetic organic chemistry.

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Towards a pharmacological genetics

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Mitosis: basic concepts

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Mitosis: towards a molecular understanding of chromosome behavior

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The spindle assembly checkpoint

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Coupling cell division and cell death to microtubule dynamics

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High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

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Mitotic mechanisms in Alzheimer's disease?

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Flow cytometry of mitotic cells

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Cytotoxic peptides hemiasterlin, hemiasterlin A and hemiasterlin B induce mitotic arrest and abnormal spindle formation

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Taxol stabilizes microtubules in mouse fibroblast cells

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Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

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(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest

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New synthetic inhibitors of microtubule depolymerization.

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How Taxol stabilises microtubule structure.

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Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function

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Microtubule polymerization dynamics

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Control of mitotic transitions by the anaphase-promoting complex

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10.1016/S1074-5521(00)00101-0

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