(Q50267304)

28 February 2018

title

Chemical genetics resulting from a passion for synthetic organic chemistry. (English)

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28 February 2018

author name string

S L Schreiber

series ordinal

1

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28 February 2018

language of work or name

English

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publication date

1 August 1998

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28 February 2018

Bioorganic & Medicinal Chemistry

published in

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28 February 2018

volume

6

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28 February 2018

issue

8

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28 February 2018

page(s)

1127-1152

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28 February 2018

Cyclobutene bridgehead olefin route to the American cockroach sex pheromone, periplanone-B

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Fiber-derived butyrate and the prevention of colon cancer

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A role for histone deacetylase activity in HDAC1-mediated transcriptional repression

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A tricyclic ring system replaces the variable regions of peptides presented by three alleles of human MHC class I molecules

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Covalent HLA-B27/peptide complex induced by specific recognition of an aziridine mimic of arginine

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Structure-based design of a cyclophilin-calcineurin bridging ligand

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Immunophilin-sensitive protein phosphatase action in cell signaling pathways

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A signaling pathway to translational control

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Synthesis and cellular characterization of the detransformation agent, (-)-depudecin

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Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides

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(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest

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Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

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Lactacystin, proteasome function, and cell fate

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cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

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Proximity versus allostery: the role of regulated protein dimerization in biology

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Dimerization as a regulatory mechanism in signal transduction

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EndocyclischeSN-Reaktionen am gesättigten Kohlenstoff? Vorläufige Mitteilung

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Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins

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7 January 2021

Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization

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7 January 2021

Controlling programmed cell death with a cyclophilin-cyclosporin-based chemical inducer of dimerization

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7 January 2021

Controlling signal transduction with synthetic ligands

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7 January 2021

Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012

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7 January 2021

Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen

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Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment

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A proliferation switch for genetically modified cells

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Probing the role of homomeric and heteromeric receptor interactions in TGF-beta signaling using small molecule dimerizers

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7 January 2021

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7 January 2021

A general strategy for producing conditional alleles of Src-like tyrosine kinases

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Design of allele-specific inhibitors to probe protein kinase signaling

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7 January 2021

Regulation of gene expression by small molecules

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7 January 2021

Genetic Contributions to Understanding Polyketide Synthases

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7 January 2021

Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale

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7 January 2021

A miniaturized arrayed assay format for detecting small molecule-protein interactions in cells

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7 January 2021

A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanodroplets

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7 January 2021

10.1016/S0968-0896(98)00126-6

Identifiers

DOI

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28 February 2018

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28 February 2018