(Q28384857)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

title

Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and Cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

author name string

Ines Witte

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Ulrich Foerstermann

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Asokan Devarajan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Srinivasa T Reddy

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

language of work or name

English

0 references

publication date

13 May 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

volume

2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

page(s)

342806

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

3 February 2020

copyright license

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death

1 reference

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One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity

20 March 2017

1 reference

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Cytochrome c/cardiolipin relations in mitochondria: a kiss of death

20 March 2017

1 reference

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Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

20 March 2017

1 reference

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The Bcl-2 apoptotic switch in cancer development and therapy

20 March 2017

1 reference

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Inflammation and insulin resistance

20 March 2017

1 reference

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The paraoxonase gene family and atherosclerosis

20 March 2017

1 reference

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Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy

20 March 2017

1 reference

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Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein

20 March 2017

1 reference

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Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids

20 March 2017

1 reference

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20 March 2017

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DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus

20 March 2017

1 reference

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Cytochrome c release from mitochondria proceeds by a two-step process

20 March 2017

1 reference

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Heart disease and stroke statistics--2011 update: a report from the American Heart Association

20 March 2017

1 reference

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Oxidative stress, inflammation, and cancer: how are they linked?

7 April 2017

1 reference

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Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Paraoxonase-2 modulates stress response of endothelial cells to oxidized phospholipids and a bacterial quorum-sensing molecule

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role?

29 September 2017

1 reference

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Paraoxonase gene mutations in amyotrophic lateral sclerosis

29 September 2017

1 reference

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Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis

29 September 2017

1 reference

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ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy

29 September 2017

1 reference

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The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

29 September 2017

1 reference

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Epigenetic inactivation of the placentally imprinted tumor suppressor gene TFPI2 in prostate carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Paraoxonase 2 is down-regulated by the Pseudomonas aeruginosa quorumsensing signal N-(3-oxododecanoyl)-L-homoserine lactone and attenuates oxidative stress induced by pyocyanin.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia

29 September 2017

1 reference

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A common mutation in paraoxonase-2 results in impaired lactonase activity.

29 September 2017

1 reference

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The double-edged sword of autophagy modulation in cancer

29 September 2017

1 reference

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New insights on oxidative stress in cancer.

29 September 2017

1 reference

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Protective effect of paraoxonase-2 against endoplasmic reticulum stress-induced apoptosis is lost upon disturbance of calcium homoeostasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Is it just paraoxonase 1 or are other members of the paraoxonase gene family implicated in atherosclerosis?

29 September 2017

1 reference

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29 September 2017

1 reference

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Dominant role of paraoxonases in inactivation of the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone

29 September 2017

1 reference

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Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice

29 September 2017

1 reference

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Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population

29 September 2017

1 reference

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Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2.

29 September 2017

1 reference

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NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Cellular redox regulation and prooxidant signaling systems: a new perspective on the free radical theory of aging.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Cellular response to endoplasmic reticulum stress: a matter of life or death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Paraoxonase 2 (PON2) expression is upregulated via a reduced-nicotinamide-adenine-dinucleotide-phosphate (NADPH)-oxidase-dependent mechanism during monocytes differentiation into macrophages

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Paraoxonase gene polymorphisms, oxidative stress, and diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Transcription profile of cells infected with human T-cell leukemia virus type I compared with activated lymphocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Paraoxonase genes and disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Paraoxonases-2 and -3 Are Important Defense Enzymes against Pseudomonas aeruginosa Virulence Factors due to Their Anti-Oxidative and Anti-Inflammatory Properties

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Genetic variation in paraoxonase-1 and paraoxonase-2 is associated with variation in plasma lipoproteins in Alberta Hutterites

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Serum paraoxonase and arylesterase activities in patients with epithelial ovarian cancer

2 June 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Investigating paraoxonase-1 gene Q192R and L55M polymorphism in patients with renal cell cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Association of CYP17, GSTP1, and PON1 polymorphisms with the risk of prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Classification of pediatric acute lymphoblastic leukemia by gene expression profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Association of lipids, lipoproteins, apolipoproteins and paraoxonase enzyme activity with premature coronary artery disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Adenovirus mediated expression of human paraoxonase 2 protects against the development of atherosclerosis in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Decreased paraoxonase-2 expression in human carotids during the progression of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Polymorphisms in the PON gene cluster are associated with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

The paraoxonase-2-310 polymorphism is associated with the presence of microvascular complications in diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Immunohistochemical analysis of paraoxonases-1 and 3 in human atheromatous plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Human paraoxonase gene cluster transgenic overexpression represses atherogenesis and promotes atherosclerotic plaque stability in ApoE-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F342806

Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361228

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

27 November 2018

1 reference

12 December 2020

Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation

1 reference

12 December 2020

Adenovirus-mediated expression of human paraoxonase 3 protects against the progression of atherosclerosis in apolipoprotein E-deficient mice

1 reference

12 December 2020

Differential expression of adipose tissue proteins between obesity-susceptible and -resistant rats fed a high-fat diet

1 reference

12 December 2020

Integrative analysis of multiple gene expression profiles applied to liver cancer study

1 reference

12 December 2020

Differential effects of antimycin on ubisemiquinone bound in different environments in isolated succinate . cytochrome c reductase complex

1 reference

12 December 2020

Comparisons of coenzyme Q bound to mitochondrial membrane proteins among different mammalian species

1 reference

12 December 2020

Human PON3, effects beyond the HDL: clues from human PON3 transgenic mice

1 reference

12 December 2020

Discovery and analysis of hepatocellular carcinoma genes using cDNA microarrays

1 reference

12 December 2020

Paraoxonase 1 (PON1) polymorphisms and prostate cancer in the CPS-II Nutrition Cohort

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/342806

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2921098

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json

OpenCitations bibliographic resource ID

3 February 2020

2921098

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

PubMed publication ID

22666600

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22666600%20AND%20SRC:MED&resulttype=core&format=json