(Q28388318)

2

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Lan H Chu

3

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Andrea Dorfleutner

4

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Christian Stehlik

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

5

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language of work or name

English

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publication date

October 2015

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published in

Molecular Immunology

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volume

67

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issue

2 Pt B

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page(s)

294-302

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cites work

1 reference

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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

20 March 2017

1 reference

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Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

20 March 2017

1 reference

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Genetics and Epigenetics of Recurrent Hydatidiform Moles: Basic Science and Genetic Counselling

20 March 2017

1 reference

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An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology

20 March 2017

1 reference

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Biochemical and structural aspects of the ATP-binding domain in inflammasome-forming human NLRP proteins

20 March 2017

1 reference

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Crystal structure of NLRC4 reveals its autoinhibition mechanism

20 March 2017

1 reference

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Structural and Functional Analysis of the NLRP4 Pyrin Domain

20 March 2017

1 reference

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The nucleotide-binding domain of NLRC5 is critical for nuclear import and transactivation activity

20 March 2017

1 reference

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Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis

20 March 2017

1 reference

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Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes

20 March 2017

1 reference

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20 March 2017

1 reference

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ATP binding by monarch-1/NLRP12 is critical for its inhibitory function

20 March 2017

1 reference

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A Shope Fibroma virus PYRIN-only protein modulates the host immune response

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Structure of the apoptotic protease-activating factor 1 bound to ADP

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

The PYRIN-CARD protein ASC is an activating adaptor for caspase-1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

GTP binding by class II transactivator: role in nuclear import

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

The Nod-like receptor (NLR) family: a tale of similarities and differences

20 March 2017

1 reference

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Evolutionary history and higher order classification of AAA+ ATPases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

An updated view on the structure and function of PYRIN domains

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

NLRP7 inter-domain interactions: the NACHT-associated domain is the physical mediator for oligomeric assembly

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

NLRP7, a nucleotide oligomerization domain-like receptor protein, is required for normal cytokine secretion and co-localizes with Golgi and the microtubule-organizing center

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Inflammasomes and their activation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Chemical probing reveals insights into the signaling mechanism of inflammasome activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Wheel of Life, Wheel of Death: A Mechanistic Insight into Signaling by STAND Proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Infevers: an evolving mutation database for auto-inflammatory syndromes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

The functions and consensus motifs of nine types of peptide segments that form different types of nucleotide-binding sites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Identification of a monocyte specific pre-interleukin 1 beta convertase activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Structural localization of disease-associated sequence variations in the NACHT and LRR domains of PYPAF1 and NOD2.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4565763

NLRP7 in the spectrum of reproductive wastage: rare non-synonymous variants confer genetic susceptibility to recurrent reproductive wastage

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26143398