(Q28471705)

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Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen

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scholarly article

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Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen (English)

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infectious disease

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Leishmania major

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based on heuristic

inferred from title

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based on heuristic

inferred from title

12

object named as

John S Lazo

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7

object named as

Peter Wipf

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Elizabeth R Sharlow

1

object named as

Elizabeth R Sharlow

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Stephanie Leimgruber

4

object named as

Stephanie Leimgruber

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5

object named as

Robyn Reed

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2

object named as

David Close

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3

object named as

Tongying Shun

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Gabriela Mustata

6

object named as

Gabriela Mustata

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10

object named as

Max Grögl

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author name string

Jacob Johnson

8

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Michael O'Neil

9

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Alan J Magill

11

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language of work or name

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publication date

3 November 2009

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PLoS Neglected Tropical Diseases

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3

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11

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e540

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copyright license

Creative Commons CC0 License

3 November 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

Neglected infections of poverty in the United States of America

1 reference

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19 March 2017

Tamoxifen is effective in the treatment of Leishmania amazonensis infections in mice

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The TriTryp phosphatome: analysis of the protein phosphatase catalytic domains

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Comparative genomic analysis of three Leishmania species that cause diverse human disease

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Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi

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The genome of the kinetoplastid parasite, Leishmania major

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Pentamidine is an inhibitor of PRL phosphatases with anticancer activity

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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Leishmaniasis emergence and climate change.

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Cutaneous leishmaniasis: therapeutic strategies and future directions

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The leishmaniases--survival and expansion in a changing world. A mini-review

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High-throughput screening assays for the identification of chemical probes

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29 September 2017

Development and optimization of high-throughput in vitro protein phosphatase screening assays

1 reference

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Leishmaniasis and poverty

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29 September 2017

Leishmania: risk to the blood supply

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Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis

1 reference

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Reconsidering the underestimated burden caused by neglected tropical diseases

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Current scenario of drug development for leishmaniasis

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PKD at the crossroads of DAG and PKC signaling

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Indazole N-oxide derivatives as antiprotozoal agents: synthesis, biological evaluation and mechanism of action studies

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Novel compounds active against Leishmania major

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Protein kinases as drug targets in trypanosomes and Leishmania

1 reference

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Nonhealing skin lesions in a sailor and a journalist returning from Iraq.

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Recent advances in antileishmanial drug development.

1 reference

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Challenges and new discoveries in the treatment of leishmaniasis.

1 reference

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Axenic culture of Leishmania amastigotes

1 reference

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In vitro assays for evaluation of drug activity against Leishmania spp.

1 reference

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Treatment of cutaneous leishmaniasis among travellers

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Leishmaniasis--current chemotherapy and recent advances in the search for novel drugs

1 reference

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Fragmental Methods in the Analysis of Biological Activities of Diverse Compound Sets

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In vitro cultivation and characterization of axenic amastigotes of Leishmania

1 reference

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Antileishmanial activities of aphidicolin and its semisynthetic derivatives

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An axenic amastigote system for drug screening

1 reference

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Activity and mode of action of acridine compounds against Leishmania donovani

1 reference

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Chemotherapy for leishmaniasis: biochemical mechanisms, clinical efficacy, and future strategies

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Berberine derivatives as antileishmanial drugs

1 reference

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29 September 2017

Recommendations for Treating Leishmaniasis with Sodium Stibogluconate (Pentostam) and Review of Pertinent Clinical Studies

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Treatment of Cutaneous Leishmaniasis with Trimethoprim-Sulfamethoxazole Combination

1 reference

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Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C.

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Combination therapy (monomycine and methyluracil) in leishmaniasis cutis

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https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0000540

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1 reference

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Synthesis and in vitro evaluation of leishmanicidal and trypanocidal activities of N-quinolin-8-yl-arylsulfonamides

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https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0000540

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Rear-view mirrors and crystal balls: a brief reflection on drug discovery.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0000540

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Colorimetric assay for screening compounds against Leishmania amastigotes grown in macrophages.

1 reference

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1 reference

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Activity of Oral Drugs against Leishmania Tropica in Human Macrophages in Vitro *

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

27 November 2018

Rifampicin treatment of cutaneous leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

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based on heuristic

inferred from PubMed ID database lookup

High selective leishmanicidal activity of 3-hydroxy-2-methylene-3-(4-bromophenyl)propanenitrile and analogous compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

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based on heuristic

inferred from PubMed ID database lookup

A randomized, double-blind, clinical trial of topical clotrimazole versus miconazole for treatment of cutaneous leishmaniasis in the eastern province of Saudi Arabia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

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based on heuristic

inferred from PubMed ID database lookup

Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Monophasic Liquid Medium (GD-NRC) for the Cultivation of Leishmania donovani

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axenic cultivation of amastigotes ofLeishmania donovaniandLeishmania majorand their infectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of clofazimine, niclosamide & amphotericin B, on electron transport of Leishmania donovani promastigotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PNTD.0000540

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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