(Q28471705)

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Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen

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scholarly article

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Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen (English)

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infectious disease

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Leishmania major

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

12

object named as

John S Lazo

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7

object named as

Peter Wipf

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Elizabeth R Sharlow

1

object named as

Elizabeth R Sharlow

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Stephanie Leimgruber

4

object named as

Stephanie Leimgruber

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5

object named as

Robyn Reed

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2

object named as

David Close

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3

object named as

Tongying Shun

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Gabriela Mustata

6

object named as

Gabriela Mustata

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10

object named as

Max Grögl

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author name string

Jacob Johnson

8

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Michael O'Neil

9

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Alan J Magill

11

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language of work or name

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publication date

3 November 2009

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PLoS Neglected Tropical Diseases

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3

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11

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e540

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copyright license

Creative Commons CC0 License

3 November 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

Neglected infections of poverty in the United States of America

1 reference

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19 March 2017

Tamoxifen is effective in the treatment of Leishmania amazonensis infections in mice

1 reference

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19 March 2017

The TriTryp phosphatome: analysis of the protein phosphatase catalytic domains

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19 March 2017

Comparative genomic analysis of three Leishmania species that cause diverse human disease

1 reference

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19 March 2017

Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi

1 reference

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19 March 2017

The genome of the kinetoplastid parasite, Leishmania major

1 reference

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19 March 2017

Pentamidine is an inhibitor of PRL phosphatases with anticancer activity

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19 March 2017

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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Roles of endogenous gamma interferon and macrophage microbicidal mechanisms in host response to chemotherapy in experimental visceral leishmaniasis

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19 March 2017

Drugs for bad bugs: confronting the challenges of antibacterial discovery

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7 April 2017

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7 April 2017

Complexities of assessing the disease burden attributable to leishmaniasis

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29 September 2017

Leishmaniasis emergence and climate change.

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29 September 2017

Development, validation and implementation of immobilized metal affinity for phosphochemicals (IMAP)-based high-throughput screening assays for low-molecular-weight compound libraries

1 reference

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29 September 2017

Kinetoplastids: related protozoan pathogens, different diseases

1 reference

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29 September 2017

Cutaneous leishmaniasis: therapeutic strategies and future directions

1 reference

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29 September 2017

The leishmaniases--survival and expansion in a changing world. A mini-review

1 reference

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29 September 2017

High-throughput screening assays for the identification of chemical probes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Development and optimization of high-throughput in vitro protein phosphatase screening assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Leishmaniasis and poverty

1 reference

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29 September 2017

Leishmania: risk to the blood supply

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis

1 reference

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29 September 2017

Reconsidering the underestimated burden caused by neglected tropical diseases

1 reference

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29 September 2017

Current scenario of drug development for leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

PKD at the crossroads of DAG and PKC signaling

1 reference

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29 September 2017

Indazole N-oxide derivatives as antiprotozoal agents: synthesis, biological evaluation and mechanism of action studies

1 reference

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29 September 2017

Novel compounds active against Leishmania major

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Protein kinases as drug targets in trypanosomes and Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Nonhealing skin lesions in a sailor and a journalist returning from Iraq.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Recent advances in antileishmanial drug development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Challenges and new discoveries in the treatment of leishmaniasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Axenic culture of Leishmania amastigotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

In vitro assays for evaluation of drug activity against Leishmania spp.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Treatment of cutaneous leishmaniasis among travellers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Leishmaniasis--current chemotherapy and recent advances in the search for novel drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Fragmental Methods in the Analysis of Biological Activities of Diverse Compound Sets

1 reference

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29 September 2017

A functionally conserved member of the FTZ-F1 nuclear receptor family from Schistosoma mansoni

1 reference

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29 September 2017

Steroidogenic factor 1: an essential mediator of endocrine development

1 reference

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29 September 2017

In vitro cultivation and characterization of axenic amastigotes of Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Antileishmanial activities of aphidicolin and its semisynthetic derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Science, medicine, and the future: Leishmaniasis

1 reference

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29 September 2017

A comparison of the activities of three amphotericin B lipid formulations against experimental visceral and cutaneous leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Axenically cultured amastigote forms as an in vitro model for investigation of antileishmanial agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

An axenic amastigote system for drug screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Activity and mode of action of acridine compounds against Leishmania donovani

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

In vitro effects of mycophenolic acid and allopurinol against Leishmania tropica in human macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Chemotherapy for leishmaniasis: biochemical mechanisms, clinical efficacy, and future strategies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Berberine derivatives as antileishmanial drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Recommendations for Treating Leishmaniasis with Sodium Stibogluconate (Pentostam) and Review of Pertinent Clinical Studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

29 September 2017

Treatment of Cutaneous Leishmaniasis with Trimethoprim-Sulfamethoxazole Combination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

2 June 2018

Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

2 June 2018

Combination therapy (monomycine and methyluracil) in leishmaniasis cutis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

2 June 2018

Role of hexosamine biosynthesis in Leishmania growth and virulence

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0000540

21 January 2018

Tamoxifen as a potential antileishmanial agent: efficacy in the treatment of Leishmania braziliensis and Leishmania chagasi infections

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0000540

21 January 2018

A simple colorimetric method to screen drug cytotoxicity against Leishmania using the dye Alamar Blue.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0000540

21 January 2018

Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0000540

21 January 2018

Synthesis and in vitro evaluation of leishmanicidal and trypanocidal activities of N-quinolin-8-yl-arylsulfonamides

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0000540

21 January 2018

Rear-view mirrors and crystal balls: a brief reflection on drug discovery.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0000540

21 January 2018

Colorimetric assay for screening compounds against Leishmania amastigotes grown in macrophages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

27 November 2018

Immunochemotherapy in American cutaneous leishmaniasis: immunological aspects before and after treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

27 November 2018

Efficacy of ivermectin on the infectivity of Leishmania major promastigotes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

27 November 2018

Activity of Oral Drugs against Leishmania Tropica in Human Macrophages in Vitro *

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765639

27 November 2018

Rifampicin treatment of cutaneous leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nifurtimox in the treatment of South American leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High selective leishmanicidal activity of 3-hydroxy-2-methylene-3-(4-bromophenyl)propanenitrile and analogous compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized, double-blind, clinical trial of topical clotrimazole versus miconazole for treatment of cutaneous leishmaniasis in the eastern province of Saudi Arabia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Monophasic Liquid Medium (GD-NRC) for the Cultivation of Leishmania donovani

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axenic cultivation of amastigotes ofLeishmania donovaniandLeishmania majorand their infectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doxycycline for the treatment of cutaneous leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of clofazimine, niclosamide & amphotericin B, on electron transport of Leishmania donovani promastigotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19888337

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PNTD.0000540

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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