(Q28474358)

1

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Birgit Busse

2

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Matthias Riemenschneider

3

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Steffi Neubauer

4

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Katharina Seck

5

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Hanns-Georg Klein

6

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Marion Kiechle

7

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Florian Lordick

Creative Commons Attribution 4.0 International

8

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language of work or name

English

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publication date

2008

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published in

PLOS One

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volume

3

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issue

12

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page(s)

e4003

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copyright license

start time

23 December 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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1 reference

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Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure

19 March 2017

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Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil

19 March 2017

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Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W

19 March 2017

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cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria

19 March 2017

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Pharmacogenomics of drug-metabolizing enzymes and drug transporters in chemotherapy

19 March 2017

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Adjuvant strategies in breast cancer: new prospectives, questions and reflections at the end of 2007 St Gallen International Expert Consensus Conference

29 September 2017

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Chemotherapy of advanced gastric cancer

29 September 2017

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Dihydropyrimidine dehydrogenase activity and the IVS14+1G>A mutation in patients developing 5FU-related toxicity

29 September 2017

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Therapy for metastatic colorectal cancer

29 September 2017

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Review of capecitabine as oral treatment of gastric, gastroesophageal, and esophageal cancers

29 September 2017

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Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil

29 September 2017

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Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype.

29 September 2017

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Clinical implications of dihydropyrimidine dehydrogenase on 5-FU pharmacology

29 September 2017

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The role of pharmacogenetics and pharmacogenomics in cancer chemotherapy with 5-fluorouracil

29 September 2017

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Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.

29 September 2017

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A comparative analysis of translated dihydropyrimidine dehydrogenase cDNA; conservation of functional domains and relevance to genetic polymorphisms

29 September 2017

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Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile

2 June 2018

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Is capecitabine safe in patients with gastrointestinal cancer and dihydropyrimidine dehydrogenase deficiency?

2 June 2018

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Mutations in exon 14 of dihydropyrimidine dehydrogenase and 5-Fluorouracil toxicity in Portuguese colorectal cancer patients

21 January 2018

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Dihydropyrimidine dehydrogenase activity in 150 healthy Japanese volunteers and identification of novel mutations

21 January 2018

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High prevalence of the IVS14 + 1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity

21 January 2018

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Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group

21 January 2018

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Detailed analysis of five mutations in dihydropyrimidine dehydrogenase detected in cancer patients with 5-fluorouracil-related side effects

21 January 2018

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Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial

21 January 2018

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Analysis of the DPYD gene implicated in 5-fluorouracil catabolism in a cohort of Caucasian individuals

21 January 2018

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Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test

21 January 2018

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Pharmacogenetics in oncology: 5-fluorouracil and the dihydropyrimidine dehydrogenase

21 January 2018

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Relationship between 5-fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients

21 January 2018

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The dihydrouracil/uracil ratio in plasma, clinical and genetic analysis for screening of dihydropyrimidine dehydrogenase deficiency in colorectal cancer patients treated with 5-fluorouracil

21 January 2018

1 reference

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5FU and oxaliplatin-containing chemotherapy in two dihydropyrimidine dehydrogenase-deficient patients

27 November 2018

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High-throughput genotyping by DHPLC of the dihydropyrimidine dehydrogenase gene implicated in (fluoro)pyrimidine catabolism

27 November 2018

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DPYD*5 gene mutation contributes to the reduced DPYD enzyme activity and chemotherapeutic toxicity of 5-FU: results from genotyping study on 75 gastric carcinoma and colon carcinoma patients

27 November 2018

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12 December 2020

Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences

1 reference

12 December 2020

Known variant DPYD alleles do not explain DPD deficiency in cancer patients

1 reference

12 December 2020

Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene

1 reference

12 December 2020

Dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil associated toxicity

1 reference

12 December 2020

Adjuvant therapy for colon cancer

1 reference

12 December 2020

Pharmacogenetics of capecitabine in advanced breast cancer patients

1 reference

12 December 2020

A rapid and inexpensive method for anticipating severe toxicity to fluorouracil and fluorouracil-based chemotherapy

1 reference

12 December 2020

Clinical relevance of different dihydropyrimidine dehydrogenase gene single nucleotide polymorphisms on 5-fluorouracil tolerance

1 reference

12 December 2020

FRA1E common fragile site breaks map within a 370kilobase pair region and disrupt the dihydropyrimidine dehydrogenase gene (DPYD)

1 reference

12 December 2020

Increased dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil and leucovorin

1 reference

12 December 2020

The dihydrouracil/uracil ratios in plasma and toxicities of 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer patients

1 reference

12 December 2020