(Q28478926)

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Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures

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scholarly article

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Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures (English)

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1 reference

based on heuristic

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object named as

Patrick Bulau

12

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author name string

Katharina Diepold

1

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Katrin Bomans

2

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Michael Wiedmann

3

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Boris Zimmermann

4

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Andreas Petzold

5

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Tilman Schlothauer

6

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Robert Mueller

7

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Bernd Moritz

8

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Jan Olaf Stracke

9

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Michael Mølhøj

10

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Dietmar Reusch

11

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language of work or name

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publication date

2012

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7

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1

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e30295

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copyright license

Creative Commons Attribution 4.0 International

17 January 2012

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April 2022 Public Data File from Crossref

copyright status

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describes a project that uses

liquid chromatography–mass spectrometry

1 reference

based on heuristic

inferred from title

Identification of potential sites for tryptophan oxidation in recombinant antibodies using tert-butylhydroperoxide and quantitative LC-MS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

19 March 2017

Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

29 September 2017

Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

29 September 2017

18O labeling method for identification and quantification of succinimide in proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

29 September 2017

Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

29 September 2017

Stepwise deamidation of ribonuclease A at five sites determined by top down mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

29 September 2017

Identification and characterization of deamidation sites in the conserved regions of human immunoglobulin gamma antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

29 September 2017

Biological significance of isoaspartate and its repair system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

29 September 2017

Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

29 September 2017

In vitro aging of calmodulin generates isoaspartate at multiple Asn-Gly and Asp-Gly sites in calcium-binding domains II, III, and IV

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

29 September 2017

Does the chemical instability of aspartyl and asparaginyl residues in proteins contribute to erythrocyte aging? The role of protein carboxyl methylation reactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

29 September 2017

Non-enzymic post-translational modification of proteins in aging. A review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

29 September 2017

Integration of mass spectrometry in analytical biotechnology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

29 September 2017

Isomerization of an aspartic acid residue in the complementarity-determining regions of a recombinant antibody to human IgE: identification and effect on binding affinity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

2 June 2018

Identification of succinimide sites in proteins by N-terminal sequence analysis after alkaline hydroxylamine cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

2 June 2018

Isolation and characterization of a succinimide variant of methionyl human growth hormone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

2 June 2018

Methylation at specific altered aspartyl and asparaginyl residues in glucagon by the erythrocyte protein carboxyl methyltransferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

20 June 2018

In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030295

21 January 2018

Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030295

21 January 2018

Accumulation of succinimide in a recombinant monoclonal antibody in mildly acidic buffers under elevated temperatures

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030295

21 January 2018

Broadband detection electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry to reveal enzymatically and chemically induced deamidation reactions within peptides

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030295

21 January 2018

Measurement of deamidation of intact proteins by isotopic envelope and mass defect with ion cyclotron resonance Fourier transform mass spectrometry

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030295

21 January 2018

Direct identification and quantification of aspartyl succinimide in an IgG2 mAb by RapiGest assisted digestion

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030295

21 January 2018

Identification and characterization of oxidation and deamidation sites in monoclonal rat/mouse hybrid antibodies

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030295

21 January 2018

Identification of isomerization and racemization of aspartate in the Asp-Asp motifs of a therapeutic protein

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030295

21 January 2018

Heterogeneity of recombinant antibodies: linking structure to function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

27 November 2018

Identification of multiple sources of charge heterogeneity in a recombinant antibody.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3260267

27 November 2018

Identification of sites of degradation in a therapeutic monoclonal antibody by peptide mapping

1 reference

https://pubmed.ncbi.nlm.nih.gov/22272329

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical and physical stability of chimeric L6, a mouse-human monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/22272329

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accurate determination of succinimide degradation products using high fidelity trypsin digestion peptide map analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22272329

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple forms of cytochrome c in the rat. Precursor-product relationship between the main component Cy I and the minor components Cy II and Cy 3 in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22272329

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0030295

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2012PLoSO...730295D

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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