(Q28484072)

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A new slow releasing, H₂S generating compound, GYY4137 relaxes spontaneous and oxytocin-stimulated contractions of human and rat pregnant myometrium

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A new slow releasing, H₂S generating compound, GYY4137 relaxes spontaneous and oxytocin-stimulated contractions of human and rat pregnant myometrium (English)

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Susan Wray

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Hayley Robinson

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publication date

2012

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7

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9

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e46278

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Creative Commons Attribution 4.0 International

27 September 2012

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April 2022 Public Data File from Crossref

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Involvement of redox-signalling in endogenous hydrogen sulfide production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

19 March 2017

Signaling by gasotransmitters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

19 March 2017

Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

19 March 2017

H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

19 March 2017

Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

19 March 2017

The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

19 March 2017

Simultaneous measurements of changes in sarcoplasmic reticulum and cytosolic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

19 March 2017

Hydrogen sulfide inhibits L-type calcium currents depending upon the protein sulfhydryl state in rat cardiomyocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Physiological implications of hydrogen sulfide: a whiff exploration that blossomed

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Hydrogen sulfide in biochemistry and medicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

High turnover rates for hydrogen sulfide allow for rapid regulation of its tissue concentrations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

A practical look at the chemistry and biology of hydrogen sulfide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Expression of cystathionine β-synthase and cystathionine γ-lyase in human pregnant myometrium and their roles in the control of uterine contractility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Expression of ATP-sensitive potassium channels in human pregnant myometrium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Hydrogen sulfide and cell signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Hydrogen sulfide and oxygen sensing in the cardiovascular system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Making and working with hydrogen sulfide: The chemistry and generation of hydrogen sulfide in vitro and its measurement in vivo: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Molecular mechanism for H(2)S-induced activation of K(ATP) channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

The endogenous production of hydrogen sulphide in intrauterine tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Sex hormones and excitation-contraction coupling in the uterus: the effects of oestrous and hormones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Insights into the uterus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

In situ calcium signaling: no calcium sparks detected in rat myometrium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

A role for voltage-gated, but not Ca2+-activated, K+ channels in regulating spontaneous contractile activity in myometrium from virgin and pregnant rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Lipid rafts, the sarcoplasmic reticulum and uterine calcium signalling: an integrated approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Calcium signalling in smooth muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

The management of preterm labor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Hydrogen sulfide as a neuromodulator.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Aperistaltic ureter in upper urinary tract infection — cause or effect?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

29 September 2017

Mechanism of vasorelaxation and role of endogenous hydrogen sulfide production in mouse aorta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

2 June 2018

Effect of synthesized GYY4137, a slowly releasing hydrogen sulfide donor, on cell viability and distribution of hydrogen sulfide in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

2 June 2018

The smooth muscle relaxant effect of hydrogen sulphide in vitro: evidence for a physiological role to control intestinal contractility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

2 June 2018

The effects of metabolic inhibition and acidification on force production in the rat uterus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

2 June 2018

Hydrogen sulfide activates Ca²⁺ sparks to induce cerebral arteriole dilatation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Free and acid-labile hydrogen sulfide concentrations in mouse tissues: anomalously high free hydrogen sulfide in aortic tissue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Mechanisms of action of hydrogen sulfide in relaxation of mouse distal colonic smooth muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Modulation of Ca(2+) signalling in human vascular endothelial cells by hydrogen sulfide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Dual effect of exogenous hydrogen sulfide on the spontaneous contraction of gastric smooth muscle in guinea-pig.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Hydrogen sulphide in the hypothalamus causes an ATP-sensitive K+ channel-dependent decrease in blood pressure in freely moving rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Dual modulation of the tension of isolated gastric artery and gastric mucosal circulation by hydrogen sulfide in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Hydrogen sulfide causes relaxation in mouse bronchial smooth muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Dysfunctional labor and myometrial lactic acidosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Effects of L-type Ca(2+)-channel blockade, K(+)(ATP)-channel opening and nitric oxide on human uterine contractility in relation to gestational age and labour

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Effect of inhibiting the sarcoplasmic reticulum on spontaneous and oxytocin-induced contractions of human myometrium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

L-cysteine and sodium hydrosulphide inhibit spontaneous contractility in isolated pregnant rat uterine strips in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459845

27 November 2018

Properties of voltage-activated [Ca2+]i transients in single smooth muscle cells isolated from pregnant rat uterus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23029460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular calcium stores and agonist-induced contractions in isolated human myometrium

1 reference

https://pubmed.ncbi.nlm.nih.gov/23029460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/23029460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen sulphide regulates intracellular pH in vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23029460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of the contractile properties of human myometrium obtained from the upper and lower uterine segments

1 reference

https://pubmed.ncbi.nlm.nih.gov/23029460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gestational changes in uterine L-type calcium channel function and expression in guinea pig

1 reference

https://pubmed.ncbi.nlm.nih.gov/23029460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of inhibiting Rho-associated kinase with Y-27632 on force and intracellular calcium in human myometrium

1 reference

https://pubmed.ncbi.nlm.nih.gov/23029460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of metabolic inhibition and changes of intracellular pH on potassium permeability and contraction of rat uterus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23029460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of pH and inorganic phosphate on force production in alpha-toxin-permeabilized isolated rat uterine smooth muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/23029460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Ca2+]i signaling in pregnant human myometrium

1 reference

https://pubmed.ncbi.nlm.nih.gov/23029460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of metabolic inhibition on intracellular Ca2+, phosphorylation of myosin regulatory light chain and force in rat smooth muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/23029460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen sulfide inhibits the spontaneous and oxytocin-induced contractility of human pregnant myometrium

1 reference

https://pubmed.ncbi.nlm.nih.gov/23029460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0046278

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2012PLoSO...746278R

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