(Q28485402)

Santiago Garcia-Vallvé

13

0 references

Gerard Pujadas

Gerard Pujadas

12

0 references

Montserrat Pinent

Montserrat Pinent

9

0 references

Gerhard Wolber

Gerhard Wolber

6

0 references

Anna Ardévol

Anna Ardévol

10

0 references

Klaus R. Liedl

Klaus R Liedl

5

0 references

Lídia Cedó

4

Lidia Cedó

1 reference

ORCID Public Data File 2021

Laura Guasch

1

Laura Guasch

0 references

Anna Castell-Auví

3

Anna Castell-Auví

0 references

Miquel Mulero

8

Miquel Mulero

0 references

author name string

Esther Sala

2

0 references

Markus Muehlbacher

7

0 references

Cristina Valls

Creative Commons Attribution 4.0 International

11

0 references

language of work or name

English

0 references

publication date

2012

0 references

published in

PLOS One

0 references

volume

7

0 references

issue

11

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page(s)

e50816

0 references

copyright license

start time

30 November 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Partial agonists activate PPARgamma using a helix 12 independent mechanism

19 March 2017

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Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

19 March 2017

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The mechanisms of action of PPARs

19 March 2017

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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The PPARs: from orphan receptors to drug discovery

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A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPARγ partial agonists

7 April 2017

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Pharmacophore-driven identification of PPARγ agonists from natural sources.

29 September 2017

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Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

29 September 2017

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Analysis and comparison of 2D fingerprints: insights into database screening performance using eight fingerprint methods

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Identification of bioactive natural products by pharmacophore-based virtual screening

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Virtual Screening as a Technique for PPAR Modulator Discovery

29 September 2017

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Structural insight into PPARgamma ligands binding.

29 September 2017

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Discovery of novel PPAR ligands by a virtual screening approach based on pharmacophore modeling, 3D shape, and electrostatic similarity screening

29 September 2017

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FAF-Drugs2: free ADME/tox filtering tool to assist drug discovery and chemical biology projects

29 September 2017

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PPAR modulators and PPAR pan agonists for metabolic diseases: the next generation of drugs targeting peroxisome proliferator-activated receptors?

29 September 2017

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Novel PPAR-gamma agonists identified from a natural product library: a virtual screening, induced-fit docking and biological assay study

29 September 2017

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The next generation of PPAR drugs: do we have the tools to find them?

29 September 2017

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Molecular basis of selective PPARgamma modulation for the treatment of Type 2 diabetes

29 September 2017

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Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators.

29 September 2017

1 reference

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PHASE: a new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results

29 September 2017

1 reference

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Efficient overlay of small organic molecules using 3D pharmacophores

29 September 2017

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Selective PPAR modulators, dual and pan PPAR agonists: multimodal drugs for the treatment of type 2 diabetes and atherosclerosis

29 September 2017

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Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.

29 September 2017

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29 September 2017

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LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters

29 September 2017

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The Uppsala Electron-Density Server

29 September 2017

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Nuclear receptors and the control of metabolism

29 September 2017

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1,3-Diphenyl-1H-pyrazole derivatives as a new series of potent PPARγ partial agonists.

29 September 2017

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Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor.

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3511273

Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3511273

Toxicity determined in vitro by morphological alterations and neutral red absorption

2 June 2018

1 reference

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Nuclear receptors, nuclear-receptor factors, and nuclear-receptor-like orphans form a large paralog cluster in Homo sapiens.

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050816

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050816

Changes in lipolysis and hormone-sensitive lipase expression caused by procyanidins in 3T3-L1 adipocytes

21 January 2018

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12 December 2020

Structural insights for the design of new PPARgamma partial agonists with high binding affinity and low transactivation activity

1 reference

12 December 2020

Potential remains for PPAR-targeted drugs

1 reference

12 December 2020

An automated approach for clustering an ensemble of NMR-derived protein structures into conformationally related subfamilies

1 reference

12 December 2020

Structure-based pharmacophore screening for natural-product-derived PPARgamma agonists

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0050816

Identifiers

DOI

1 reference

3117755

ADS bibcode

2012PLoSO...750816G

0 references

3117755

1 reference

1 reference

1 reference