(Q28487329)

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The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice

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scholarly article

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The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice (English)

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Britta Siegmund

object named as

Britta Siegmund

2

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5

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Stefan Endres

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author name string

Florian Rieder

1

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Daniela S Bundschuh

3

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Hans-Anton Lehr

4

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Andreas Eigler

6

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language of work or name

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publication date

2013

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8

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2

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e56867

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Creative Commons Attribution 4.0 International

28 February 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

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Infliximab for induction and maintenance therapy for ulcerative colitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

19 March 2017

Inflammatory Bowel Disease

1 reference

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19 March 2017

Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

19 March 2017

The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

29 September 2017

Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

29 September 2017

Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

29 September 2017

Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

29 September 2017

Phosphodiesterase-4: selective and dual-specificity inhibitors for the therapy of chronic obstructive pulmonary disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

29 September 2017

PDE4 inhibition: a novel approach for the treatment of inflammatory bowel disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

29 September 2017

In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

29 September 2017

Adenosine kinase inhibitor GP515 improves experimental colitis in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

29 September 2017

Therapeutic potential of phosphodiesterase-4 and -3 inhibitors in Th1-mediated autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

29 September 2017

Antitumor necrosis factor therapy for inflammatory bowel disease: a review of agents, pharmacology, clinical results, and safety

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

29 September 2017

The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

29 September 2017

Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

29 September 2017

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

29 September 2017

Dextran sulfate sodium-induced colonic histopathology, but not altered epithelial ion transport, is reduced by inhibition of phosphodiesterase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

2 June 2018

Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

2 June 2018

Phosphodiesterase isozymes: molecular targets for novel antiasthma agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

2 June 2018

Clinicopathologic study of dextran sulfate sodium experimental murine colitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

2 June 2018

The acute toxic effect of the phosphodiesterase inhibitor rolipram on plasma osmolality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

2 June 2018

In vitro desensitization to lipopolysaccharide suppresses tumour necrosis factor, interleukin-1 and interleukin-6 gene expression in a similar fashion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

2 June 2018

The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056867

21 January 2018

Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056867

21 January 2018

Roflumilast--an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056867

21 January 2018

Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056867

21 January 2018

Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056867

21 January 2018

Role of interleukin-10 in a murine model of dextran sulfate sodium-induced colitis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056867

21 January 2018

Amelioration of collagen II-induced arthritis in rats by the type IV phosphodiesterase inhibitor Rolipram

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056867

21 January 2018

Selective inhibition of phosphodiesterase-4 ameliorates chronic colitis and prevents intestinal fibrosis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056867

21 January 2018

Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056867

21 January 2018

Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585290

27 November 2018

Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23468885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mouse CD69 gene. Structure, expression, and mapping to the NK gene complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/23468885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/23468885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental models of inflammatory bowel disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23468885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized, placebo-controlled, phase II study of tetomilast in active ulcerative colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23468885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific type IV phosphodiesterase inhibitor rolipram mitigates experimental colitis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23468885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23468885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0056867

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2013PLoSO...856867R

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