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The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products
scientific journal article
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scholarly article
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PubMed
PubMed ID
8612582
retrieved
24 January 2017
title
The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products
(English)
1 reference
stated in
PubMed
PubMed ID
8612582
retrieved
24 January 2017
main subject
C-abl oncogene 1, non-receptor tyrosine kinase
1 reference
stated in
GOA release 2020-03-11
Transformation related protein 53
1 reference
stated in
GOA release 2020-03-11
RB transcriptional corepressor 1
1 reference
stated in
GOA release 2020-03-11
author name string
S. T. Wen
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
8612582
retrieved
24 January 2017
P. K. Jackson
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
8612582
retrieved
24 January 2017
R. A. Van Etten
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
8612582
retrieved
24 January 2017
language of work or name
English
0 references
publication date
1 April 1996
1 reference
stated in
PubMed
PubMed ID
8612582
retrieved
24 January 2017
published in
The EMBO Journal
1 reference
stated in
PubMed
PubMed ID
8612582
retrieved
24 January 2017
volume
15
1 reference
stated in
PubMed
PubMed ID
8612582
retrieved
24 January 2017
page(s)
1583–1595
1 reference
stated in
PubMed
PubMed ID
8612582
retrieved
24 January 2017
issue
7
1 reference
stated in
PubMed
PubMed ID
8612582
retrieved
24 January 2017
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Two nuclear localization signals present in the basic-helix 1 domains of MyoD promote its active nuclear translocation and can function independently
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Introduction of a loss-of-function point mutation from the SH3 region of the Caenorhabditis elegans sem-5 gene activates the transforming ability of c-abl in vivo and abolishes binding of proline-rich ligands in vitro.
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Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation
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N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl
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Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential
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29 September 2017
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29 September 2017
Isolation of temperature-sensitive tyrosine kinase mutants of v-abl oncogene by screening with antibodies for phosphotyrosine
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BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias
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29 September 2017
Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor
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29 September 2017
Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line
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Oncogenic v-Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context
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Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo
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HPV-16 E7 or adenovirus E1A can overcome the growth arrest of cells immortalized with a temperature-sensitive p53.
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2 June 2018
Cell cycle arrest by tyrosine kinase Abl involves altered early mitogenic response.
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Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents
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2 June 2018
The nuclear tyrosine kinase c-Abl negatively regulates cell growth
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2 June 2018
Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome
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2 June 2018
Alternative 5' exons in c-abl mRNA.
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2 June 2018
Nuclear location signals in polyoma virus large-T.
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2 June 2018
Requirement for c-ras proteins during viral oncogene transformation
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2 June 2018
The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization
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2 June 2018
Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity.
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PubMed Central
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2 June 2018
The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif
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2 June 2018
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.
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2 June 2018
Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes
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2 June 2018
Cell cycle-regulated binding of c-Abl tyrosine kinase to DNA
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Dominant negative MYC blocks transformation by ABL oncogenes
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450068
retrieved
2 June 2018
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450068
retrieved
27 November 2018
p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=450068
retrieved
27 November 2018
Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/8612582
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Use of a general purpose mammalian expression vector for studying intracellular protein targeting: identification of critical residues in the nuclear lamin A/C nuclear localization signal
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/8612582
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A temperature sensitive mutant of the human p53, Val138, arrests rat cell growth without induced expression of cip1/waf1/sdi1 after temperature shift-down
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/8612582
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Differential expression of cellular oncogenes during pre- and postnatal development of the mouse
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/8612582
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
c-abl has a sequence-specific enhancer binding activity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/8612582
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/8612582
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
OpenCitations bibliographic resource ID
1263406
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1263406
PMCID
450068
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1263406
PubMed ID
8612582
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1263406
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