(Q28513295)

25 January 2017

title

Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse (English)

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Phosphodiesterase 4A, cAMP specific

25 January 2017

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GOA release 2020-03-11

author name string

J. A. Cherry

series ordinal

1

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25 January 2017

B. E. Thompson

series ordinal

2

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25 January 2017

V. Pho

series ordinal

3

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25 January 2017

language of work or name

English

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publication date

19 March 2001

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Biochimica et Biophysica Acta

25 January 2017

published in

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25 January 2017

volume

1518

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25 January 2017

issue

1-2

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25 January 2017

page(s)

27–35

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Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

25 January 2017

cites work

1 reference

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7 January 2021

Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8.

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7 January 2021

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

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7 January 2021

Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes

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7 January 2021

The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors

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7 January 2021

Purification, characterization and analysis of rolipram inhibition of a human type-IVA cyclic AMP-specific phosphodiesterase expressed in yeast

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7 January 2021

Results of a phase II study of the antidepressant effect of rolipram

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7 January 2021

A multicenter double-blind study of three different doses of the new cAMP-phosphodiesterase inhibitor rolipram in patients with major depressive disorder

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7 January 2021

Effects of therapeutic agents on cyclic AMP metabolism in vitro

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7 January 2021

Regional cyclic nucleotide phosphodiesterase activity in cat central nervous system: effects of benzodiazepines.

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7 January 2021

Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor

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7 January 2021

Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase

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7 January 2021

Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene

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A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons

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7 January 2021

An improved assay of cyclic 3',5'-nucleotide phosphodiesterases with QAE-Sephadex columns

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7 January 2021

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

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7 January 2021

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

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7 January 2021

Physical mapping and promoter structure of the murine cAMP-specific phosphodiesterase pde4a gene

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7 January 2021

Identification of a conserved domain among cyclic nucleotide phosphodiesterases from diverse species

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7 January 2021

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3

1 reference

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7 January 2021

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

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7 January 2021

Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum

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7 January 2021

Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases

1 reference

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7 January 2021

The determination of enzyme inhibitor constants

1 reference

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7 January 2021

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

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7 January 2021

Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice

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7 January 2021

The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram

1 reference

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7 January 2021

Rolipram, a novel antidepressant drug, reverses the hypothermia and hypokinesia of monoamine-depleted mice by an action beyond postsynaptic monoamine receptors

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7 January 2021

Clinical and Biochemical Effects of the Selective Phosphodiesterase Inhibitor Rolipram in Depressed Inpatients Controlled by Determination of Plasma Level

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7 January 2021

Pharmacokinetics of (+)-rolipram and (-)-rolipram in healthy volunteers

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7 January 2021

Pharmacokinetics of rolipram in the rhesus and cynomolgus monkeys, the rat and the rabbit. Studies on species differences

1 reference

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7 January 2021

Plasma diazepam and desmethyldiazepam concentrations during long-term diazepam therapy

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7 January 2021

High dose diazepam in schizophrenia.

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7 January 2021

Massive benzodiazepine requirements during acute alcohol withdrawal

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7 January 2021

Comparison of single- and repeated-dose pharmacokinetics of diazepam.

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7 January 2021

The pathomorphology of schizophrenia and mood disorders: similarities and differences

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7 January 2021

Functional neuropathology in Parkinson's disease

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7 January 2021

10.1016/S0167-4781(01)00164-6

Identifiers

DOI

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1 reference