(Q28550224)

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Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies

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scholarly article

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Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies (English)

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infectious disease

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African trypanosomiasis

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7

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author name string

Christian Burri

1

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Patrick D Yeramian

2

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James L Allen

3

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Ada Merolle

4

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Kazadi Kyanza Serge

5

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Alain Mpanya

6

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Victor Kande Betu Ku Mesu

8

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Constantin Miaka Mia Bilenge

9

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Jean-Pierre Fina Lubaki

10

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Alfred Mpoo Mpoto

11

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Mark Thompson

12

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Blaise Fungula Munungu

13

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Francisco Manuel

14

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Théophilo Josenando

15

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Sonja C Bernhard

16

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Carol A Olson

17

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Johannes Blum

18

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Richard R Tidwell

19

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Gabriele Pohlig

20

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language of work or name

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publication date

February 2016

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PLoS Neglected Tropical Diseases

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10

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2

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e0004362

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copyright license

Creative Commons Attribution 4.0 International

16 February 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

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Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis

1 reference

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19 March 2017

SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis

1 reference

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Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

1 reference

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19 March 2017

Cardiac alterations in human African trypanosomiasis (T.b. gambiense) with respect to the disease stage and antiparasitic treatment

1 reference

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19 March 2017

In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness

1 reference

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Determination of an optimal dosing regimen for fexinidazole, a novel oral drug for the treatment of human African trypanosomiasis: first-in-human studies

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Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis

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The human African trypanosomiasis control and surveillance programme of the World Health Organization 2000-2009: the way forward

1 reference

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29 September 2017

Socio-economic aspects of neglected diseases: sleeping sickness and visceral leishmaniasis

1 reference

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29 September 2017

New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289

1 reference

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29 September 2017

Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration

1 reference

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Pafuramidine for Pneumocystis jiroveci pneumonia in HIV-infected individuals

1 reference

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29 September 2017

Human trypanosomiasis in the Ivory Coast: therapy and problems

1 reference

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29 September 2017

The therapy of trypanosomiasis

1 reference

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29 September 2017

Evaluation of the haematocrit centrifuge and other techniques for the field diagnosis of human trypanosomiasis and filariasis

1 reference

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29 September 2017

Trypanosoma brucei: Miniature anion-exchange centrifugation technique for detection of low parasitaemias: Adaptation for field use.

1 reference

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29 September 2017

Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis

1 reference

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21 January 2018

Pharmacokinetics and metabolism of the prodrug DB289 (2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2,5-bis(4-guanylphenyl)furan dihydrochloride).

1 reference

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21 January 2018

[Diamidine therapy of the lymphatic-blood phase of human trypanosomiasis in French Equatorial Africa]

1 reference

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27 November 2018

The efficacy of pentamidine in the treatment of early-late stage Trypanosoma brucei gambiense trypanosomiasis

1 reference

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A card-agglutination test with stained trypanosomes (C.A.T.T.) for the serological diagnosis of T. B. gambiense trypanosomiasis

1 reference

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27 November 2018

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10.1371/JOURNAL.PNTD.0004362

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